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Maternal medical history and medication use during pregnancy, neonatal demographic information and status at birth were collected through the electronic medical record system. Statistical software was used to analyze the possible relationship between perinatal factors and CRP on admission after birth.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 820 neonates were analyzed, including 463 males and 357 females with a mean gestational age (GA) of 36.07\u2009\u00b1\u20093.30 weeks. (1) Multifactor Logistic regression analysis: larger GA (OR: 1.13, 95%CI: 1.00-1.28, <jats:italic>P<\/jats:italic>\u2009=\u20090.042), premature rupture of membranes (PROM)\u2009\u2265\u200918\u00a0h (OR: 2.39, 95%CI: 1.35\u20134.23, <jats:italic>P<\/jats:italic>\u2009=\u20090.003) and maternal autoimmune diseases (OR: 5.30, 95%CI: 2.15\u201313.07, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were independent risk factors for CRP\u2009\u2265\u20098\u00a0mg\/L. Cesarean delivery (OR 0.40, 95%CI: 0.26\u20130.60, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) was independent protective factor for CRP\u2009\u2265\u20098\u00a0mg\/L. (2) Threshold effect analysis: A non-linear relationship was found between GA and CRP. When GA is less than 33.9 weeks, the risk of CRP\u2009\u2265\u20098\u00a0mg\/L was reduced by 28% with one week increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and when GA is more than 33.9 weeks, the risk of CRP\u2009\u2265\u20098\u00a0mg\/L was increased by 61% with one week increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>GA, PROM, maternal autoimmune diseases and cesarean delivery were all independent influences neonatal CRP\u2009\u2265\u20098\u00a0mg\/L on admission, and there was a nonlinear relationship between GA and neonatal CRP\u2009\u2265\u20098\u00a0mg\/L on admission.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12887-024-04583-8","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T06:02:37Z","timestamp":1706767357000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Factors influencing C-reactive protein status on admission in neonates after birth"],"prefix":"10.1186","volume":"24","author":[{"given":"Chuanding","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojie","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohe","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyan","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4385-2871","authenticated-orcid":false,"given":"Zhengchang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"4583_CR1","unstructured":"Nehring SM, Goyal A, Patel BC, C Reactive Protein. 2022 Jul 18. 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Written informed consent to participate in this research was provided by the participants\u2019 legal guardian\/next of kin. (Ethics Review Department No. 202307164).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflict of interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"89"}}