{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:26:01Z","timestamp":1791055561852,"version":"4.1.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Tumor lysis syndrome (TLS) is a hematologic oncological emergency characterized by metabolic and electrolyte imbalances. On breakdown of tumor cells, enormous amounts of potassium, phosphate, and nucleic acids are released into systemic circulation. TLS mainly occurs during chemotherapy. However, there are rare incidences of spontaneous tumor lysis syndrome (STLS) prior to commencement of therapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>In the case being reported, the child had just undergone a biopsy. As the incision was being closed, there was a sudden onset of high fever, arrhythmia, severe hyperkalemia, hypocalcemia, and acidosis. Following timely symptomatic treatment and continuous renal replacement therapy(CRRT), the child\u2019s laboratory results improved, and organ function was restored to normal. The final pathological diagnosis confirmed Burkitt lymphoma. The boy is currently on maintenance chemotherapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>TLS is a potentially life-threatening complication in hematologic oncology. Several important conclusions can be drawn from this case, reminding clinicians to: (1) be fully aware of the risk factors of TLS and evaluate the level of risk; (2) pay attention to the possibility of STLS during operation, if surgical procedures are necessary and operate with minimal trauma and in the shortest time possibly; (3) take preoperative prophylaxis actively for high-risk TLS patients, including aggressive fluid management and rational use of diuretics and uric-acid-lowering drugs. In addition, this case confirms the effectiveness of CRRT for severe STLS.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12887-024-04679-1","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T09:02:33Z","timestamp":1711184553000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Spontaneous tumor lysis syndrome (STLS) during biopsy for burkitt lymphoma: a case report"],"prefix":"10.1186","volume":"24","author":[{"given":"Sirui","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,23]]},"reference":[{"key":"4679_CR1","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1001\/jamaoncol.2018.0613","volume":"4","author":"A Gupta","year":"2018","unstructured":"Gupta A, Moore JA. Tumor lysis syndrome. JAMA Oncol. 2018;4:895.","journal-title":"JAMA Oncol"},{"key":"4679_CR2","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1056\/NEJMra0904569","volume":"364","author":"SC Howard","year":"2011","unstructured":"Howard SC, Jones DP, Pui CH. The tumor lysis syndrome. N Engl J Med. 2011;364:1844\u201354.","journal-title":"N Engl J Med"},{"key":"4679_CR3","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/0002-9343(80)90286-7","volume":"68","author":"LF Cohen","year":"1980","unstructured":"Cohen LF, Balow JE, Magrath IT, Poplack DG, Ziegler JL. Acute tumor lysis syndrome. A review of 37 patients with Burkitt\u2019s lymphoma. Am J Med. 1980;68:486\u201391.","journal-title":"Am J Med"},{"key":"4679_CR4","first-page":"e8355","volume":"12","author":"D Findakly","year":"2020","unstructured":"Findakly D, Luther RD 3rd, Wang J. Tumor lysis syndrome in solid tumors: a Comprehensive Literature Review, New insights, and novel strategies to improve outcomes. Cureus. 2020;12:e8355.","journal-title":"Cureus"},{"key":"4679_CR5","doi-asserted-by":"crossref","unstructured":"Cheung WL, Hon KL, Fung CM, Leung AK. Tumor lysis syndrome in childhood malignancies. Drugs Context. 2020; 9.","DOI":"10.7573\/dic.2019-8-2"},{"key":"4679_CR6","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1093\/ckj\/sfu061","volume":"7","author":"G Mavani","year":"2014","unstructured":"Mavani G, Wolf V, Orin G. Spontaneous tumor lysis syndrome in a case of B-cell non-hodgkin\u2019s lymphoma. Clin Kidney J. 2014;7:422\u20133.","journal-title":"Clin Kidney J"},{"key":"4679_CR7","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1365-2044.2006.04873.x","volume":"62","author":"MH Lee","year":"2007","unstructured":"Lee MH, Cheng KI, Jang RC, Hsu JH, Dai ZK, Wu JR. Tumour lysis syndrome developing during an operation. Anaesthesia. 2007;62:85\u20137.","journal-title":"Anaesthesia"},{"key":"4679_CR8","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1097\/00000542-200609000-00042","volume":"105","author":"M Chanimov","year":"2006","unstructured":"Chanimov M, Koren-Michowitz M, Cohen ML, Pilipodi S, Bahar M. Tumor lysis syndrome induced by dexamethasone. Anesthesiology. 2006;105:633\u20134.","journal-title":"Anesthesiology"},{"key":"4679_CR9","doi-asserted-by":"publisher","first-page":"752","DOI":"10.2967\/jnumed.118.217380","volume":"60","author":"K Huang","year":"2019","unstructured":"Huang K, Brenner W, Prasad V. Tumor lysis syndrome: a rare but serious complication of Radioligand therapies. J Nucl Med. 2019;60:752\u20135.","journal-title":"J Nucl Med"},{"key":"4679_CR10","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1002\/(SICI)1096-911X(199606)26:6<417::AID-MPO9>3.0.CO;2-K","volume":"26","author":"M Levin","year":"1996","unstructured":"Levin M, Cho S. Acute tumor lysis syndrome in high grade lymphoblastic lymphoma after a prolonged episode of fever. Med Pediatr Oncol. 1996;26:417\u20138.","journal-title":"Med Pediatr Oncol"},{"key":"4679_CR11","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1001\/archinte.1987.00370050063011","volume":"147","author":"JM Rimmer","year":"1987","unstructured":"Rimmer JM, Horn JF, Gennari FJ. Hyperkalemia as a complication of drug therapy. Arch Intern Med. 1987;147:867\u20139.","journal-title":"Arch Intern Med"},{"key":"4679_CR12","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1200\/JCO.2007.15.0177","volume":"26","author":"B Coiffier","year":"2008","unstructured":"Coiffier B, Altman A, Pui CH, Younes A, Cairo MS. Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review. J Clin Oncol. 2008;26:2767\u201378.","journal-title":"J Clin Oncol"},{"key":"4679_CR13","doi-asserted-by":"crossref","unstructured":"Cairo MS, Bishop M. Tumour lysis syndrome: new therapeutic strategies and classification. Br J Haematol. 2004;127: 3\u201311.","DOI":"10.1111\/j.1365-2141.2004.05094.x"},{"key":"4679_CR14","doi-asserted-by":"crossref","unstructured":"Cairo MS, Coiffier B, Reiter A, Younes A. Recommendations for the evaluation of risk and prophylaxis of tumour lysis syndrome (TLS) in adults and children with malignant diseases: an expert TLS panel consensus. Br J Haematol. 2010;149: 578\u201386.","DOI":"10.1111\/j.1365-2141.2010.08143.x"},{"key":"4679_CR15","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1159\/000509643","volume":"13","author":"W Wesem\u00fcller","year":"2020","unstructured":"Wesem\u00fcller W, Taverna C. Spontaneous tumor lysis syndrome. Case Rep Oncol. 2020;13:1116\u201324.","journal-title":"Case Rep Oncol"},{"key":"4679_CR16","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1111\/bjh.16278","volume":"188","author":"U Durani","year":"2020","unstructured":"Durani U, Hogan WJ. Emergencies in haematology: tumour lysis syndrome. Br J Haematol. 2020;188:494\u2013500.","journal-title":"Br J Haematol"},{"key":"4679_CR17","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1111\/bjh.13403","volume":"169","author":"GL Jones","year":"2015","unstructured":"Jones GL, Will A, Jackson GH, Webb NJ, Rule S. Guidelines for the management of tumour lysis syndrome in adults and children with haematological malignancies on behalf of the British Committee for Standards in Haematology. Br J Haematol. 2015;169:661\u201371.","journal-title":"Br J Haematol"},{"key":"4679_CR18","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1053\/j.ackd.2013.07.001","volume":"21","author":"FP Wilson","year":"2014","unstructured":"Wilson FP, Berns JS. Tumor lysis syndrome: new challenges and recent advances. Adv Chronic Kidney Dis. 2014;21:18\u201326.","journal-title":"Adv Chronic Kidney Dis"},{"key":"4679_CR19","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.chest.2018.09.004","volume":"155","author":"S Tandukar","year":"2019","unstructured":"Tandukar S, Palevsky PM. Continuous renal replacement therapy: who, when, why, and how. Chest. 2019;155:626\u201338.","journal-title":"Chest"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-024-04679-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12887-024-04679-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-024-04679-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T09:03:37Z","timestamp":1711184617000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpediatr.biomedcentral.com\/articles\/10.1186\/s12887-024-04679-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,23]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4679"],"URL":"https:\/\/doi.org\/10.1186\/s12887-024-04679-1","relation":{},"ISSN":["1471-2431"],"issn-type":[{"value":"1471-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,23]]},"assertion":[{"value":"18 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from the child\u2019s legal guardian for the publication of any potentially identifiable images or data included in this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was obtained from legal guardian\/parent of participant for publication of identifying information\/images in an online open-access publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"209"}}