{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:05:21Z","timestamp":1788433521542,"version":"build-2803163510"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T00:00:00Z","timestamp":1714176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T00:00:00Z","timestamp":1714176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>This study aimed to compare the efficacy of neurally adjusted ventilatory assist (NAVA) to synchronized intermittent mandatory ventilation (SIMV) in preterm infants requiring mechanical ventilation after patent ductus arteriosus (PDA) ligation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A retrospective analysis was conducted on intubated preterm infants who underwent PDA ligation at our hospital from July 2021 to January 2023. Infants were divided into NAVA or SIMV groups based on the ventilation mode after surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Fifty preterm infants were included. During treatment, peak inspiratory pressure (PIP) and mean airway pressure (MAP) were lower with NAVA compared to SIMV (PIP: 19.1\u2009\u00b1\u20092.9 vs. 22.4\u2009\u00b1\u20093.6 cmH<jats:sub>2<\/jats:sub>O, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; MAP: 9.1\u2009\u00b1\u20091.8 vs. 10.9\u2009\u00b1\u20092.7 cmH<jats:sub>2<\/jats:sub>O, <jats:italic>P<\/jats:italic>\u2009=\u20090.002). PaO<jats:sub>2<\/jats:sub> and PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> were higher with NAVA (PaO<jats:sub>2<\/jats:sub>: 94.0\u2009\u00b1\u200911.7 vs. 84.8\u2009\u00b1\u200915.8\u00a0mmHg, <jats:italic>P<\/jats:italic>\u2009=\u20090.031; PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub>: 267 [220\u2013322] vs. 232 [186\u2013290] mmHg, <jats:italic>P<\/jats:italic>\u2009=\u20090.025). Less sedation was required with NAVA (midazolam: 1.5\u2009\u00b1\u20090.5 vs. 1.1\u2009\u00b1\u20090.3\u00a0\u03bcg\/kg\/min, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Compared to SIMV, early use of NAVA post PDA ligation in preterm infants was associated with decreased PIP and MAP. Early NAVA was also associated with reduced sedation needs and improved oxygenation. However, further studies are warranted to quantify the benefits of NAVA ventilation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12887-024-04727-w","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T04:02:25Z","timestamp":1714190545000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of neurally adjusted ventilatory assist and synchronized intermittent mandatory ventilation in preterm infants after patent ductus arteriosus ligation: a retrospective study"],"prefix":"10.1186","volume":"24","author":[{"given":"Hui-Zi","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Feng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Rong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,27]]},"reference":[{"issue":"6","key":"4727_CR1","doi-asserted-by":"publisher","first-page":"F505","DOI":"10.1136\/archdischild-2013-303816","volume":"98","author":"A Sellmer","year":"2013","unstructured":"Sellmer A, Bjerre JV, Schmidt MR, McNamara PJ, Hjortdal VE, H\u00f8st B, Bech BH, Henriksen TB. Morbidity and mortality in preterm neonates with patent ductus arteriosus on day 3. Arch Dis Child Fetal Neonatal Ed. 2013;98(6):F505\u201310. https:\/\/doi.org\/10.1136\/archdischild-2013-303816.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"2","key":"4727_CR2","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1053\/j.semperi.2011.09.022","volume":"36","author":"RI Clyman","year":"2012","unstructured":"Clyman RI, Couto J, Murphy GM. Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all? Semin Perinatol. 2012;36(2):123\u20139. https:\/\/doi.org\/10.1053\/j.semperi.2011.09.022.","journal-title":"Semin Perinatol"},{"key":"4727_CR3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jpeds.2017.06.054","volume":"189","author":"RI Clyman","year":"2017","unstructured":"Clyman RI, Liebowitz M. Treatment and nontreatment of the patent ductus arteriosus: identifying their roles in neonatal morbidity. J Pediatr. 2017;189:13\u20137. https:\/\/doi.org\/10.1016\/j.jpeds.2017.06.054.","journal-title":"J Pediatr"},{"issue":"12","key":"4727_CR4","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1038\/71012","volume":"5","author":"C Sinderby","year":"1999","unstructured":"Sinderby C, Navalesi P, Beck J, Skrobik Y, Comtois N, Friberg S, Gottfried SB, Lindstr\u00f6m L. Neural control of mechanical ventilation in respiratory failure. Nat Med. 1999;5(12):1433\u20136. https:\/\/doi.org\/10.1038\/71012.","journal-title":"Nat Med"},{"issue":"2","key":"4727_CR5","doi-asserted-by":"publisher","first-page":"312.e1","DOI":"10.1016\/j.jcrc.2013.08.006","volume":"29","author":"M Piastra","year":"2014","unstructured":"Piastra M, De Luca D, Costa R, Pizza A, De Sanctis R, Marzano L, Biasucci D, Visconti F, Conti G. Neurally adjusted ventilatory assist vs pressure support ventilation in infants recovering from severe acute respiratory distress syndrome: nested study. J Crit Care. 2014;29(2):312.e1\u20133125. https:\/\/doi.org\/10.1016\/j.jcrc.2013.08.006.","journal-title":"J Crit Care"},{"issue":"5","key":"4727_CR6","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/j.jpeds.2011.10.014","volume":"160","author":"H Stein","year":"2012","unstructured":"Stein H, Howard D. Neurally adjusted ventilatory assist in neonates weighing <1500 grams: a retrospective analysis. J Pediatr. 2012;160(5):786\u20139.e1. https:\/\/doi.org\/10.1016\/j.jpeds.2011.10.014.","journal-title":"J Pediatr"},{"issue":"6","key":"4727_CR7","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/jp.2012.136","volume":"33","author":"H Stein","year":"2013","unstructured":"Stein H, Alosh H, Ethington P, White DB. Prospective crossover comparison between NAVA and pressure control ventilation in premature neonates less than 1500 grams. J Perinatol. 2013;33(6):452\u20136. https:\/\/doi.org\/10.1038\/jp.2012.136.","journal-title":"J Perinatol"},{"issue":"11","key":"4727_CR8","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1007\/s00134-011-2352-8","volume":"37","author":"KC Clement","year":"2011","unstructured":"Clement KC, Thurman TL, Holt SJ, Heulitt MJ. Neurally triggered breaths reduce trigger delay and improve ventilator response times in ventilated infants with bronchiolitis. Intensive Care Med. 2011;37(11):1826\u201332. https:\/\/doi.org\/10.1007\/s00134-011-2352-8.","journal-title":"Intensive Care Med"},{"issue":"1","key":"4727_CR9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1055\/s-2008-1063497","volume":"3","author":"JP Canarelli","year":"1993","unstructured":"Canarelli JP, Poulain H, Clamadieu C, Ricard J, Maingourd Y, Quintard JM. Ligation of the patent ductus arteriosus in premature infants\u2013indications and procedures. Eur J Pediatr Surg. 1993;3(1):3\u20135. https:\/\/doi.org\/10.1055\/s-2008-1063497.","journal-title":"Eur J Pediatr Surg"},{"issue":"18","key":"4727_CR10","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","volume":"342","author":"RG Brower","year":"2000","unstructured":"Acute Respiratory Distress Syndrome Network, Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342(18):1301\u20138. https:\/\/doi.org\/10.1056\/NEJM200005043421801.","journal-title":"N Engl J Med"},{"issue":"1","key":"4727_CR11","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s12890-017-0427-1","volume":"17","author":"DC Martin","year":"2017","unstructured":"Martin DC, Richards GN. Predicted body weight relationships for protective ventilation - unisex proposals from pre-term through to adult. BMC Pulm Med. 2017;17(1):85. https:\/\/doi.org\/10.1186\/s12890-017-0427-1.","journal-title":"BMC Pulm Med"},{"issue":"3","key":"4727_CR12","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1378\/chest.06-1909","volume":"131","author":"C Sinderby","year":"2007","unstructured":"Sinderby C, Beck J, Spahija J, de Marchie M, Lacroix J, Navalesi P, Slutsky AS. Inspiratory muscle unloading by neurally adjusted ventilatory assist during maximal inspiratory efforts in healthy subjects. Chest. 2007;131(3):711\u20137. https:\/\/doi.org\/10.1378\/chest.06-1909.","journal-title":"Chest"},{"issue":"12","key":"4727_CR13","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1038\/s41372-020-00840-7","volume":"40","author":"ME Morgan","year":"2020","unstructured":"Morgan ME, Kukora S, Nemshak M, Shuman CJ. Neonatal pain, agitation, and sedation scale\u2019s use, reliability, and validity: a systematic review. J Perinatol. 2020;40(12):1753\u201363. https:\/\/doi.org\/10.1038\/s41372-020-00840-7.","journal-title":"J Perinatol"},{"issue":"4","key":"4727_CR14","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1053\/j.semperi.2018.05.006","volume":"42","author":"RI Clyman","year":"2018","unstructured":"Clyman RI. Patent ductus arteriosus, its treatments, and the risks of pulmonary morbidity. Semin Perinatol. 2018;42(4):235\u201342. https:\/\/doi.org\/10.1053\/j.semperi.2018.05.006.","journal-title":"Semin Perinatol"},{"issue":"1","key":"4727_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cnur.2007.10.001","volume":"43","author":"SK Frazier","year":"2008","unstructured":"Frazier SK. Cardiovascular effects of mechanical ventilation and weaning. Nurs Clin North Am. 2008;43(1):1\u201315; v. https:\/\/doi.org\/10.1016\/j.cnur.2007.10.001.","journal-title":"Nurs Clin North Am"},{"issue":"5","key":"4727_CR16","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1053\/siny.2002.0129","volume":"7","author":"MA Attar","year":"2002","unstructured":"Attar MA, Donn SM. Mechanisms of ventilator-induced lung injury in premature infants. Semin Neonatol. 2002;7(5):353\u201360. https:\/\/doi.org\/10.1053\/siny.2002.0129.","journal-title":"Semin Neonatol"},{"issue":"9","key":"4727_CR17","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1002\/ppul.24413","volume":"54","author":"S Karikari","year":"2019","unstructured":"Karikari S, Rausa J, Flores S, Loomba RS. Neurally adjusted ventilatory assist versus conventional ventilation in the pediatric population: are there benefits? Pediatr Pulmonol. 2019;54(9):1374\u201381. https:\/\/doi.org\/10.1002\/ppul.24413.","journal-title":"Pediatr Pulmonol"},{"issue":"2","key":"4727_CR18","doi-asserted-by":"publisher","first-page":"208","DOI":"10.4187\/respcare.05625","volume":"63","author":"B Crulli","year":"2018","unstructured":"Crulli B, Khebir M, Toledano B, Vobecky S, Poirier N, Emeriaud G. Neurally adjusted ventilatory assist after pediatric cardiac surgery: clinical experience and impact on ventilation pressures. Respir Care. 2018;63(2):208\u201314. https:\/\/doi.org\/10.4187\/respcare.05625.","journal-title":"Respir Care"},{"issue":"1","key":"4727_CR19","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12887-016-0717-4","volume":"16","author":"JM Liet","year":"2016","unstructured":"Liet JM, Barri\u00e8re F, Gaillard-Le Roux B, Bourgoin P, Legrand A, Joram N. Physiological effects of invasive ventilation with neurally adjusted ventilatory assist (NAVA) in a crossover study. BMC Pediatr. 2016;16(1):180. https:\/\/doi.org\/10.1186\/s12887-016-0717-4.","journal-title":"BMC Pediatr"},{"issue":"1","key":"4727_CR20","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1002\/ppul.22995","volume":"50","author":"M Kallio","year":"2015","unstructured":"Kallio M, Peltoniemi O, Anttila E, Pokka T, Kontiokari T. Neurally adjusted ventilatory assist (NAVA) in pediatric intensive care\u2013a randomized controlled trial. Pediatr Pulmonol. 2015;50(1):55\u201362. https:\/\/doi.org\/10.1002\/ppul.22995.","journal-title":"Pediatr Pulmonol"},{"issue":"5","key":"4727_CR21","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/ped.13233","volume":"59","author":"J Lee","year":"2017","unstructured":"Lee J, Kim HS, Jung YH, Choi CW, Jun YH. Neurally adjusted ventilatory assist for infants under prolonged ventilation. Pediatr Int. 2017;59(5):540\u20134. https:\/\/doi.org\/10.1111\/ped.13233.","journal-title":"Pediatr Int"},{"issue":"5","key":"4727_CR22","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1007\/s00134-012-2535-y","volume":"38","author":"P de la Oliva","year":"2012","unstructured":"de la Oliva P, Sch\u00fcffelmann C, G\u00f3mez-Zamora A, Villar J, Kacmarek RM. Asynchrony, neural drive, ventilatory variability and COMFORT: NAVA versus pressure support in pediatric patients. A non-randomized cross-over trial. Intensive Care Med. 2012;38(5):838\u201346. https:\/\/doi.org\/10.1007\/s00134-012-2535-y.","journal-title":"Intensive Care Med"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-024-04727-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12887-024-04727-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-024-04727-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T04:03:50Z","timestamp":1714190630000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpediatr.biomedcentral.com\/articles\/10.1186\/s12887-024-04727-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,27]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4727"],"URL":"https:\/\/doi.org\/10.1186\/s12887-024-04727-w","relation":{},"ISSN":["1471-2431"],"issn-type":[{"value":"1471-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,27]]},"assertion":[{"value":"17 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The research protocol was approved by the Ethics Committee of Fujian Children\u2019s Hospital (No.2022ETKLR12026). All procedures performed in studies involving human participants were in accordance with the ethics standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethics standards. The requirement for informed consent was waived by the Ethics Committee of the Fujian Children\u2019s Hospital because of the retrospective nature of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"277"}}