{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:33:06Z","timestamp":1789662786580,"version":"4.0.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T00:00:00Z","timestamp":1714176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T00:00:00Z","timestamp":1714176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Little has been done to establish biobanks for studying the environment and lifestyle risk factors for diseases among the school-age children. The Minhang Pediatric Biobank (MPB) cohort study aims to identify factors associated with health and diseases of school-aged children living in the urban or suburban area of Shanghai.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This population-based cohort study was started in all sub-districts\/towns of Minhang district of Shanghai in 2014. First-grade students in elementary school were enrolled during the time of their routine physical examinations, with self-administered questionnaires completed by their primary caregivers. Additional information was extracted from multiple health information systems. Urine and saliva samples were collected during the baseline survey and follow-up visits.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>At the end of 2014 academic year, a total number of 8412 children and their parents were recruited, including 4339 boys and 4073 girls. All the participants completed the baseline survey and physical examination, and 7128 urine and 2767 saliva samples were collected. The five most prevalent childhood diseases in this population were dental caries, bronchitis, pneumonia, asthma and overweight\/obese.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The MPB cohort has been successfully established, serving as a useful platform for future research relating to the genetic, environmental and lifestyle risk factors for childhood diseases.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12887-024-04763-6","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T09:01:35Z","timestamp":1714208495000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Minhang Pediatric Biobank cohort study: protocol overview and baseline characteristics"],"prefix":"10.1186","volume":"24","author":[{"given":"Xiaosa","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liujie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9468-0232","authenticated-orcid":false,"given":"Zengliang","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,27]]},"reference":[{"issue":"4","key":"4763_CR1","doi-asserted-by":"publisher","first-page":"378","DOI":"10.3390\/ijerph14040378","volume":"14","author":"AN Zeba","year":"2017","unstructured":"Zeba AN, Yam\u00e9ogo MT, Tougouma SJ, Kassi\u00e9 D, Fournet F. Can Urbanization, Social and spatial disparities help to understand the rise of cardiometabolic risk factors in Bobo-Dioulasso? A study in a secondary City of Burkina Faso, West Africa. Int J Env Res Public Health. 2017;14(4):378.","journal-title":"Int J Env Res Public Health"},{"issue":"23","key":"4763_CR2","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1001\/jama.2018.5158","volume":"319","author":"CL Ogden","year":"2018","unstructured":"Ogden CL, Fryar CD, Hales CM, Carroll MD, Aoki Y, Freedman DS. Differences in obesity prevalence by demographics and Urbanization in US Children and Adolescents, 2013\u20132016. JAMA. 2018;319(23):2410\u20138.","journal-title":"JAMA"},{"issue":"1","key":"4763_CR3","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1186\/1471-2458-7-358","volume":"7","author":"R-J Yang","year":"2007","unstructured":"Yang R-J, Sheu J-J, Chen H-S, Lin K-C, Huang H-L. Morbidity at elementary school entry differs by sex and level of residence urbanization: a comparative cross-sectional study. BMC Public Health. 2007;7(1):358.","journal-title":"BMC Public Health"},{"issue":"5","key":"4763_CR4","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/j.1365-263X.2009.00979.x","volume":"19","author":"B Christian","year":"2009","unstructured":"Christian B, Evans RW. Has urbanization become a risk factor for dental caries in Kerala, India: a cross-sectional study of children aged 6 and 12 years. Int J Paediatr Dent. 2009;19(5):330\u20137.","journal-title":"Int J Paediatr Dent"},{"issue":"3","key":"4763_CR5","doi-asserted-by":"publisher","first-page":"e1001779","DOI":"10.1371\/journal.pmed.1001779","volume":"12","author":"C Sudlow","year":"2015","unstructured":"Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, Downey P, Elliott P, Green J, Landray M, et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12(3):e1001779\u2013e1001779.","journal-title":"PLoS Med"},{"issue":"5596","key":"4763_CR6","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1126\/science.298.5596.1158","volume":"298","author":"J Kaiser","year":"2002","unstructured":"Kaiser J. Population Databases Boom, From Iceland to the U.S. Science. 2002;298(5596):1158\u201361.","journal-title":"Science"},{"issue":"2","key":"4763_CR7","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1093\/ije\/dym276","volume":"37","author":"P Elliott","year":"2008","unstructured":"Elliott P. on behalf of UKB, Peakman TC, on behalf of UKB: The UK Biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine. Int J Epidemiol. 2008;37(2):234\u201344.","journal-title":"Int J Epidemiol"},{"key":"4763_CR8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2147\/CLEP.S33042","volume":"4","author":"H Christensen","year":"2012","unstructured":"Christensen H, Nielsen JS, S\u00f8rensen KM, Melbye M, Brandslund I. New national Biobank of The Danish center for strategic research on type 2 diabetes (DD2). Clin Epidemiol. 2012;4:37\u201342.","journal-title":"Clin Epidemiol"},{"issue":"6","key":"4763_CR9","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1093\/ije\/dyr120","volume":"40","author":"Z Chen","year":"2011","unstructured":"Chen Z, Chen J, Collins R, Guo Y, Peto R, Wu F, Li L. on behalf of the China Kadoorie Biobank collaborative g: China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up. Int J Epidemiol. 2011;40(6):1652\u201366.","journal-title":"Int J Epidemiol"},{"issue":"1","key":"4763_CR10","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/2043-9113-1-24","volume":"1","author":"\u00c1 V\u00e9gv\u00e1ri","year":"2011","unstructured":"V\u00e9gv\u00e1ri \u00c1, Welinder C, Lindberg H, Fehniger TE, Marko-Varga G. Biobank resources for future patient care: developments, principles and concepts. J Clin Bioinforma. 2011;1(1):24.","journal-title":"J Clin Bioinforma"},{"issue":"4","key":"4763_CR11","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.clinbiochem.2013.11.017","volume":"47","author":"MJ McQueen","year":"2014","unstructured":"McQueen MJ, Keys JL, Bamford K, Hall K. The challenge of establishing, growing and sustaining a large biobank: A personal perspective. Clin Biochem. 2014;47(4):239\u201344.","journal-title":"Clin Biochem"},{"issue":"2","key":"4763_CR12","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1089\/bio.2015.1324","volume":"13","author":"L Zhou","year":"2015","unstructured":"Zhou L, Nath N, Markovich O, Yuksel A, Roberts A, Catchpoole D. The Tumour Bank of The Children\u2019s Hospital at Westmead. Biopreservation and Biobanking. 2015;13(2):147\u20138.","journal-title":"Biopreservation and Biobanking"},{"issue":"1","key":"4763_CR13","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1017\/S1745855208005954","volume":"3","author":"M Dixon-Woods","year":"2008","unstructured":"Dixon-Woods M, Wilson D, Jackson C, Cavers D, Pritchard-Jones K. Human Tissue and 'the Public': The Case of Childhood Cancer Tumour Banking. BioSocieties. 2008;3(1):57\u201380.","journal-title":"BioSocieties."},{"issue":"4","key":"4763_CR14","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1093\/ije\/dyl131","volume":"35","author":"C Jiang","year":"2006","unstructured":"Jiang C, Thomas GN, Lam TH, Schooling CM, Zhang W, Lao X, Adab P, Liu B, Leung GM, Cheng KK. Cohort Profile: The Guangzhou Biobank Cohort Study, a Guangzhou-Hong Kong\u2013Birmingham collaboration. Int J Epidemiol. 2006;35(4):844\u201352.","journal-title":"Int J Epidemiol"},{"key":"4763_CR15","unstructured":"Minhang District Government: About Minhang. http:\/\/www.shmh.gov.cn\/ (2023). Accessed 03 Dec 2023."},{"key":"4763_CR16","doi-asserted-by":"publisher","first-page":"9307475","DOI":"10.1155\/2021\/9307475","volume":"2021","author":"AJ Turkson","year":"2021","unstructured":"Turkson AJ, Ayiah-Mensah F, Nimoh V. Handling Censoring and Censored Data in Survival Analysis: A Standalone Systematic Literature Review. Int J Math Math Sci. 2021;2021:9307475.","journal-title":"Int J Math Math Sci"},{"issue":"11","key":"4763_CR17","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1001\/jama.2022.1816","volume":"327","author":"AM Lipsky","year":"2022","unstructured":"Lipsky AM, Greenland S. Causal Directed Acyclic Graphs. JAMA. 2022;327(11):1083\u20134.","journal-title":"JAMA"},{"key":"4763_CR18","doi-asserted-by":"publisher","first-page":"g14","DOI":"10.1136\/bmj.g14","volume":"348","author":"VWV Jaddoe","year":"2014","unstructured":"Jaddoe VWV, de Jonge LL, Hofman A, Franco OH, Steegers EAP, Gaillard R. First trimester fetal growth restriction and cardiovascular risk factors in school age children: population based cohort study. BMJ. 2014;348:g14.","journal-title":"BMJ"},{"key":"4763_CR19","doi-asserted-by":"publisher","first-page":"108581","DOI":"10.1016\/j.envres.2019.108581","volume":"177","author":"Z Ruan","year":"2019","unstructured":"Ruan Z, Qian Z, Guo Y, Zhou J, Yang Y, Acharya BK, Guo S, Zheng Y, Cummings-Vaughn LA, Rigdon SE, et al. Ambient fine particulate matter and ozone higher than certain thresholds associated with myopia in the elderly aged 50 years and above. Environ Res. 2019;177:108581.","journal-title":"Environ Res"},{"key":"4763_CR20","doi-asserted-by":"publisher","first-page":"j4587","DOI":"10.1136\/bmj.j4587","volume":"359","author":"MA Mansournia","year":"2017","unstructured":"Mansournia MA, Etminan M, Danaei G, Kaufman JS, Collins G. Handling time varying confounding in observational research. BMJ. 2017;359:j4587.","journal-title":"BMJ"},{"issue":"5","key":"4763_CR21","doi-asserted-by":"publisher","first-page":"e1266","DOI":"10.1542\/peds.2014-3111","volume":"135","author":"CR Sudfeld","year":"2015","unstructured":"Sudfeld CR, Charles McCoy D, Danaei G, Fink G, Ezzati M, Andrews KG, Fawzi WW. Linear Growth and Child Development in Low- and Middle-Income Countries: A Meta-Analysis. Pediatrics. 2015;135(5):e1266\u201375.","journal-title":"Pediatrics"},{"issue":"4","key":"4763_CR22","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1159\/000475998","volume":"70","author":"D Leite Portella","year":"2017","unstructured":"Leite Portella D, Arruda M, G\u00f3mez-Campos R, Checkin Portella G, Andruske CL, Cossio-Bola\u00f1os MA. Physical Growth and Biological Maturation of Children and Adolescents: Proposed Reference Curves. Ann Nutr Metab. 2017;70(4):329\u201337.","journal-title":"Ann Nutr Metab"},{"key":"4763_CR23","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.ridd.2018.04.025","volume":"81","author":"MK Crossman","year":"2018","unstructured":"Crossman MK, Parish SL, Hauser-Cram P, Garcia DA, Warfield ME. The influence of early intervention, informal support and the family environment on trajectories of competence for fathers raising children with developmental disabilities. Res Dev Disabil. 2018;81:122\u201333.","journal-title":"Res Dev Disabil"},{"key":"4763_CR24","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3389\/fpsyt.2017.00305","volume":"8","author":"Z-L Ruan","year":"2018","unstructured":"Ruan Z-L, Liu L, Strodl E, Fan L-J, Yin X-N, Wen G-M, Sun D-L, Xian D-X, Jiang H, Jing J, et al. Antenatal training with music and maternal talk concurrently may reduce autistic-like behaviors at around 3 Years of Age. Front Psychiatry. 2018;8:305.","journal-title":"Front Psychiatry"},{"issue":"7","key":"4763_CR25","doi-asserted-by":"publisher","first-page":"e035430","DOI":"10.1136\/bmjopen-2019-035430","volume":"10","author":"Q Zhao","year":"2020","unstructured":"Zhao Q, Chen B, Wang R, Zhu M, Shao Y, Wang N, Liu X, Zhang T, Jiang F, Wang W, et al. Cohort profile: protocol and baseline survey for the Shanghai Suburban Adult Cohort and Biobank (SSACB) study. BMJ Open. 2020;10(7):e035430.","journal-title":"BMJ Open"},{"issue":"4","key":"4763_CR26","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1177\/1367493510380081","volume":"14","author":"A Bener","year":"2010","unstructured":"Bener A, Al-Mahdi HS, Vachhani PJ, Al-Nufal M, Ali AI. Do excessive internet use, television viewing and poor lifestyle habits affect low vision in school children? J Child Health Care. 2010;14(4):375\u201385.","journal-title":"J Child Health Care"},{"issue":"4","key":"4763_CR27","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1177\/0022034520908533","volume":"99","author":"E Bernabe","year":"2020","unstructured":"Bernabe E, Marcenes W, Hernandez CR, Bailey J, Abreu LG, Alipour V, Amini S, Arabloo J, Arefi Z, Arora A, et al. Global, Regional, and National Levels and Trends in Burden of Oral Conditions from 1990 to 2017: A Systematic Analysis for the Global Burden of Disease 2017 Study. J Dent Res. 2020;99(4):362\u201373.","journal-title":"J Dent Res"},{"issue":"3","key":"4763_CR28","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1001\/jamapediatrics.2015.4276","volume":"170","author":"Global Burden of Disease Pediatrics C","year":"2016","unstructured":"Global Burden of Disease Pediatrics C. Global and national burden of diseases and injuries among children and adolescents between 1990 and 2013 findings from the global burden of disease 2013 study. JAMA Pediatrics. 2016;170(3):267\u201387.","journal-title":"JAMA Pediatrics"},{"issue":"9945","key":"4763_CR29","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","volume":"384","author":"M Ng","year":"2014","unstructured":"Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, Mullany EC, Biryukov S, Abbafati C, Abera SF, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980\u20132013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet. 2014;384(9945):766\u201381.","journal-title":"The Lancet"},{"issue":"suppl1","key":"4763_CR30","doi-asserted-by":"publisher","first-page":"i2","DOI":"10.1093\/ije\/dyn019","volume":"37","author":"TC Peakman","year":"2008","unstructured":"Peakman TC, Elliott P. The UK Biobank sample handling and storage validation studies. Int J Epidemiol. 2008;37(suppl1):i2\u20136.","journal-title":"Int J Epidemiol"},{"issue":"6","key":"4763_CR31","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.beem.2013.10.008","volume":"27","author":"U Turpeinen","year":"2013","unstructured":"Turpeinen U, H\u00e4m\u00e4l\u00e4inen E. Determination of cortisol in serum, saliva and urine. Best Pract Res Clin Endocrinol Metab. 2013;27(6):795\u2013801.","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"1","key":"4763_CR32","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/dta.2475","volume":"11","author":"AA Franke","year":"2019","unstructured":"Franke AA, Li X, Menden A, Lee MR, Lai JF. Oxytocin analysis from human serum, urine, and saliva by orbitrap liquid chromatography\u2013mass spectrometry. Drug Test Anal. 2019;11(1):119\u201328.","journal-title":"Drug Test Anal"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-024-04763-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12887-024-04763-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-024-04763-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T09:04:33Z","timestamp":1714208673000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpediatr.biomedcentral.com\/articles\/10.1186\/s12887-024-04763-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,27]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4763"],"URL":"https:\/\/doi.org\/10.1186\/s12887-024-04763-6","relation":{},"ISSN":["1471-2431"],"issn-type":[{"value":"1471-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,27]]},"assertion":[{"value":"9 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was developed in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Minhang District Center for Disease Control and Prevention (approval number: EC-P-2014\u2013006), and written informed consent was obtained from the children\u2019s parents or other caregivers.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"282"}}