{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:00:13Z","timestamp":1793196013351,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the effectiveness of phase-change-material mattress (PCM) during transportation of newborns with hypoxic ischemic encephalopathy (HIE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Randomized controlled trial of newborns with HIE from June 2016 to December 2019. Patients were randomized to transport with PCM or without PCM (control) when transferred to a cooling center in northern Vietnam. Primary outcome measure was mortality rate, secondary outcomes including temperature control and adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Fifty-Two patients in PCM-group and 61 in control group. Median rectal temperature upon arrival was 34.5\u00a0\u00b0C (IQR 33.5\u201334.8) in PCM-group and 35.1\u00a0\u00b0C (IQR 34.5\u201335.9) in control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023). Median time from birth to reach target temperature was 5.0\u2009\u00b1\u20091.4\u00a0h and 5.5\u2009\u00b1\u20091.2\u00a0h in the respective groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.065). 81% of those transported with PCM versus 62% of infants transported without (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049) had reached target temperature within the 6-h timeframe. There was no record of overcooling (&lt;\u200932\u00a0\u00b0C) in any of the groups. The was no difference in mortality rate between the two groups (33% and 34% respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05)).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Phase-change-material can be used as a safe and effective cooling method during transportation of newborns with HIE in low-resource settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>The study was retro-prospectively registered in Clinical Trials (04\/05\/2022, NCT05361473).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12887-024-04987-6","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:02:07Z","timestamp":1723075327000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cooling during transportation of newborns with hypoxic ischemic encephalopathy using phase change material mattresses in low-resource settings: a randomized controlled trial in Hanoi, Vietnam"],"prefix":"10.1186","volume":"24","author":[{"given":"Hang. 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