{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T07:29:24Z","timestamp":1767598164076},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two cases of neonatal splenic hemorrhage with acute cardiorespiratory failure are described in this report. The first case involves a full-term neonate who was found unresponsive without any witnesses and could not be successfully resuscitated. A postmortem diagnosis revealed a splenic hemorrhage. Second case is an extremely premature neonate who experienced a witnessed cardiovascular collapse on the 14th day of life. Rapid cardiovascular support was administered, resulting in a positive outcome. While splenic hemorrhage is commonly associated with traumatic events, these cases highlight the need of considering spontaneous splenic hemorrhages as a potential cause of acute neonatal compromise, even in the absence of birth-related trauma (e.g., asphyxia, prolonged labor, clavicle fractures, brachial plexus injuries). This report emphasizes the importance of including splenic hemorrhage timely in the differential diagnosis of neonatal cardiorespiratory instability, especially in the absence of more common diagnoses, and discusses the challenges associated with its recognition and treatment.<\/jats:p>","DOI":"10.1186\/s12887-024-05002-8","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T11:02:21Z","timestamp":1725534141000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neonatal cardiorespiratory failure caused by splenic hemorrhages: a case report on a fatal and a rescued case"],"prefix":"10.1186","volume":"24","author":[{"given":"Nadieh A.","family":"Jansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"T M Dittrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manouk","family":"Backes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benno","family":"Kusters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willemijn","family":"M Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Hundscheid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"5002_CR1","volume-title":"Gomella's Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 8e","author":"TL Gomella","year":"2020","unstructured":"Gomella TL, Eyal FG, Bany-Mohammed F. Gomella\u2019s Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 8e. New York, NY: McGraw-Hill Education; 2020."},{"issue":"4","key":"5002_CR2","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1055\/s-0031-1273692","volume":"21","author":"WJ De Jong","year":"2011","unstructured":"De Jong WJ, Nellensteijn DR, Ten Duis HJ, Albers MJ, Moumni ME, Hulscher JB. Blunt splenic trauma in children: are we too careful? Eur J Pediatr Surg. 2011;21(4):234\u20137.","journal-title":"Eur J Pediatr Surg"},{"key":"5002_CR3","unstructured":"Kirkeg\u00e5rd J, Avlund TH, Amanavicius N, Mortensen FV, Kissmeyer-Nielsen P. Non-operative management of blunt splenic injuries in a paediatric population: a 12-year experience. Dan Med J. 2015;62(2):A4998."},{"key":"5002_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.616247","volume":"9","author":"HP Chang","year":"2021","unstructured":"Chang HP, Fu RH, Lin JJ, Chiang MC. Prognostic Factors and Clinical Features of Neonatal Splenic Rupture\/Hemorrhage: Two Cases Reports and Literature Review. Front Pediatr. 2021;9: 616247.","journal-title":"Front Pediatr"},{"issue":"3","key":"5002_CR5","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1542\/peds.39.3.421","volume":"39","author":"AJ Eraklis","year":"1967","unstructured":"Eraklis AJ. Abdominal injury related to the trauma of birth. Pediatrics. 1967;39(3):421\u20134.","journal-title":"Pediatrics"},{"issue":"4","key":"5002_CR6","doi-asserted-by":"publisher","first-page":"E3","DOI":"10.1053\/jpsu.2002.31641","volume":"37","author":"CM Hui","year":"2002","unstructured":"Hui CM, Tsui KY. Splenic rupture in a newborn. J Pediatr Surg. 2002;37(4):E3.","journal-title":"J Pediatr Surg"},{"issue":"11","key":"5002_CR7","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1016\/S0022-3468(03)00581-5","volume":"38","author":"Y Perdomo","year":"2003","unstructured":"Perdomo Y, Fiore N, Reyna T. Splenic injury presenting with isolated scrotal findings in a stable newborn. J Pediatr Surg. 2003;38(11):1673\u20135.","journal-title":"J Pediatr Surg"},{"issue":"9","key":"5002_CR8","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1007\/s00431-017-2968-y","volume":"176","author":"CS Descamps","year":"2017","unstructured":"Descamps CS, Cneude F, Hays S, Rayet I, Piolat C, Epiard C, Debillon T. Early hypovolemic shock and abdominal distention due to neonatal splenic rupture: urgency of diagnosis and management. Eur J Pediatr. 2017;176(9):1245\u201350.","journal-title":"Eur J Pediatr"},{"issue":"2","key":"5002_CR9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1055\/s-0035-1564610","volume":"3","author":"S Tiboni","year":"2015","unstructured":"Tiboni S, Abdulmajid U, Pooboni S, Wighton C, Eradi B, Dagash H. Spontaneous Splenic Hemorrhage in the Newborn. European J Pediatr Surg Rep. 2015;3(2):71\u20133.","journal-title":"European J Pediatr Surg Rep"},{"issue":"1","key":"5002_CR10","first-page":"68","volume":"12","author":"JY Ting","year":"2006","unstructured":"Ting JY, Lam BC, Ngai CS, Leung WC, Chan KL. Splenic rupture in a premature neonate. Hong Kong Med J. 2006;12(1):68\u201370.","journal-title":"Hong Kong Med J"},{"issue":"5","key":"5002_CR11","first-page":"791","volume":"45","author":"R Ardley","year":"2019","unstructured":"Ardley R, Carone L, Smith S, Spreadborough S, Davies P, Brooks A. Blunt splenic injury in children: haemodynamic status key to guiding management, a 5-year review of practice in a UK major trauma centre. Eur J Trauma Emerg Surg. 2019;45(5):791\u20139.","journal-title":"Eur J Trauma Emerg Surg"},{"issue":"5","key":"5002_CR12","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1097\/TA.0000000000002757","volume":"89","author":"N Yung","year":"2020","unstructured":"Yung N, Solomon D, Schuster K, Christison-Lagay E. Closing the gap in care of blunt solid organ injury in children. J Trauma Acute Care Surg. 2020;89(5):894\u20139.","journal-title":"J Trauma Acute Care Surg"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-024-05002-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12887-024-05002-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-024-05002-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T11:03:31Z","timestamp":1725534211000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpediatr.biomedcentral.com\/articles\/10.1186\/s12887-024-05002-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,5]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5002"],"URL":"https:\/\/doi.org\/10.1186\/s12887-024-05002-8","relation":{},"ISSN":["1471-2431"],"issn-type":[{"value":"1471-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,5]]},"assertion":[{"value":"3 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"In both cases, we obtained Informed consent of the patients\u2019 parents to publish this article. At the request of Boet's parents, this case report is written in memory of Boet (Case 1).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"564"}}