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Use of the study database for healthcare services research is therefore fully compliant with German federal law and, accordingly, Institutional Review Board\/ethical approval and informed consent of the patient was not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Participant consent for publication"}},{"value":"All authors declare financial and non-financial conflicts of interest. TW, JW, MW and SM are employees of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA, who may own stock and\/or hold stock options in Merck & Co., Inc., Rahway, NJ, USA. TB is an employee of MSD Sharp & Dohme GmbH, Germany, who may own stock and\/or hold stock options in Merck & Co., Inc., Rahway, NJ, USA. TH was employed by Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA at the time of this study. BP, RB and NQ are employed by OXON Epidemiology. DH is employed by WIG2. DO is employed by InGef and WG was employed by InGef at the time of this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"755"}}