{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T15:52:48Z","timestamp":1794066768662,"version":"4.8.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"DOI":"10.1186\/s12887-024-05313-w","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T06:25:35Z","timestamp":1738736735000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dupilumab in children with eosinophilic esophagitis: a retrospective multicenter study"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8434-2109","authenticated-orcid":false,"given":"Mohammed","family":"Hasosah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghassan","family":"Sukkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asharf","family":"AlSahafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Zaidan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouf","family":"Ghous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmajed","family":"Alshahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyad","family":"Al Zahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naif","family":"Hasosah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansour","family":"Qurashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loie","family":"Goronfolah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Alsharief","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naglaa M.","family":"Kamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"5313_CR1","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/S1542-3565(04)00236-8","volume":"2","author":"AS Arora","year":"2004","unstructured":"Arora AS, Yamazaki K. Eosinophilic esophagitis: asthma of the esophagus? Clin Gastroenterol Hepatol. 2004;2:523\u201330.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"5313_CR2","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1177\/2050640616689525","volume":"5","author":"AJ Lucendo","year":"2017","unstructured":"Lucendo AJ, Molina-Infante J, Arias, \u00c1ngel, et al. Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults. United Eur Gastroenterol J. 2017;5:335\u201358. https:\/\/doi.org\/10.1177\/2050640616689525.","journal-title":"United Eur Gastroenterol J"},{"key":"5313_CR3","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.cgh.2009.06.023","volume":"7","author":"GA Prasad","year":"2009","unstructured":"Prasad GA, Alexander JA, Schleck CD, et al. Epidemiology of eosinophilic esophagitis over three decades in Olmsted County Minnesota. Clin Gastroenterol Hepatol. 2009;7:1055\u201361.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"5313_CR4","doi-asserted-by":"crossref","unstructured":"Furuta GT, Katzka DA. Eosinophilic esophagitis. N Engl J Med., Hirano I. Epidemiology and natural history of eosinophilic esophagitis. Gastroenterology. 2018; 154:319\u2013332.","DOI":"10.1053\/j.gastro.2017.06.067"},{"key":"5313_CR5","doi-asserted-by":"publisher","first-page":"119","DOI":"10.4103\/1319-3767.77242","volume":"17","author":"MY Hasosah","year":"2011","unstructured":"Hasosah MY, Sukkar GA, Alsahafi AF, et al. Eosinophilic esophagitis in Saudi children: symptoms, histology and endoscopy results. Saudi J Gastroenterol. 2011;17:119\u201323.","journal-title":"Saudi J Gastroenterol"},{"key":"5313_CR6","doi-asserted-by":"publisher","first-page":"292","DOI":"10.15537\/1658-3175.5921","volume":"35","author":"A Assiri","year":"2014","unstructured":"Assiri A, Saeed A. Incidence and diagnostic features of eosinophilic esophagitis in a group of children with dysphagia and gastroesophageal reflux. Saudi Med J. 2014;35:292\u20137.","journal-title":"Saudi Med J"},{"key":"5313_CR7","doi-asserted-by":"crossref","unstructured":"Saadah OI, Aburiziza AJ, Abu Shakra RI. Eosinophilic esophagitis in children from Western Saudi Arabia: relative frequency, clinical, pathologicndoscopic, and immunological study. Gastroenterol Res Pract. 2012; 2012:328253.","DOI":"10.1155\/2012\/328253"},{"key":"5313_CR8","doi-asserted-by":"publisher","first-page":"668","DOI":"10.15537\/smj.2018.7.22425","volume":"39","author":"AM Saeed","year":"2018","unstructured":"Saeed AM, Assiri AM, Al Asmi M, Ullah A. Trend, clinical presentations and diagnosis of eosinophilic esophagitis in Saudi children. Saudi Med J. 2018;39:668\u201373.","journal-title":"Saudi Med J"},{"key":"5313_CR9","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1053\/j.gastro.2020.02.038","volume":"158","author":"I Hirano","year":"2020","unstructured":"Hirano I, Chan ES, Rank MA, et al. AGA Institute and the Joint Task Force on Allergy-Immunology Practice Parameters clinical guidelines for the management of eosinophilic esophagitis. Gastroenterology. 2020;158:1776\u201386.","journal-title":"Gastroenterology"},{"key":"5313_CR10","doi-asserted-by":"publisher","first-page":"e15345","DOI":"10.1016\/j.jaip.2018.05.038","volume":"6","author":"M Chehade","year":"2018","unstructured":"Chehade M, Jones SM, Pesek RD, et al. Phenotypic characterization of eosinophilic esophagitis in a large multicenter patient population from the Consortium for Food Allergy Research. J Allergy Clin Immunol Pract. 2018;6:e15345\u2013445.","journal-title":"J Allergy Clin Immunol Pract"},{"key":"5313_CR11","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1111\/all.14151","volume":"75","author":"A Le Floc\u2019h","year":"2020","unstructured":"Le Floc\u2019h A, Allinne J, Nagashima K, et al. Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4R\u03b1 antibody, is required to broadly inhibit type 2 inflammation. Allergy. 2020;75:1188\u2013q204.","journal-title":"Allergy"},{"key":"5313_CR12","unstructured":"Food and Drug Administration. Dupixent (dupilumab). Highlights of prescribing information. 2021 (https:\/\/www.regeneron.com\/downloads\/dupixent_fpi.pdf)."},{"key":"5313_CR13","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1056\/NEJMoa2205982","volume":"387","author":"ES Dellon","year":"2022","unstructured":"Dellon ES, Rothenberg ME, Collins MH, et al. Dupilumab in adults and adolescents with eosinophilic esophagitis. N Engl J Med. 2022;387:2317\u201330.","journal-title":"N Engl J Med"},{"key":"5313_CR14","doi-asserted-by":"crossref","unstructured":"Syverson EP, Rubinstein E. Real World experience with Dupilumab in Eosinophilic Esophagitis in Children and Young adults at a Tertiary Care Pediatric Medical Center. JPGN Rep. 2022;3:e180.","DOI":"10.1097\/PG9.0000000000000180"},{"key":"5313_CR15","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1016\/j.jdcr.2020.08.036","volume":"6","author":"F Bawany","year":"2020","unstructured":"Bawany F, Franco AI, Beck LA. Dupilumab: one therapy to treat multiple atopic diseases. JAAD Case Rep. 2020;6:1150\u20132.","journal-title":"JAAD Case Rep"},{"key":"5313_CR16","doi-asserted-by":"publisher","first-page":"e00887","DOI":"10.14309\/crj.0000000000000887","volume":"9","author":"G Nambiar","year":"2022","unstructured":"Nambiar G, Rahhal R, Davis BP, Xiong Y, Cheung D. Refractory Pediatric Fibrostenotic Eosinophilic Esophagitis treated with Dupilumab. ACG Case Rep J. 2022;9:e00887.","journal-title":"ACG Case Rep J"},{"key":"5313_CR17","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1097\/MPG.0000000000003901","volume":"77","author":"N Nguyen","year":"2023","unstructured":"Nguyen N, Burger C, Skirka S, et al. One year into Dupilumab: physician and patient experiences in initiating Dupilumab for Pediatric Eosinophilic Esophagitis. J Pediatr Gastroenterol Nutr. 2023;77:536\u20139.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"5313_CR18","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.anai.2022.12.014","volume":"130","author":"SS Aceves","year":"2023","unstructured":"Aceves SS, Dellon ES, Greenhawt M, Hirano I, Liacouras CA, Spergel JM. Clinical guidance for the use of dupilumab in eosinophilic esophagitis: a yardstick. Ann Allergy Asthma Immunol. 2023;130:371\u20138.","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"24","key":"5313_CR19","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1056\/NEJMoa2312282","volume":"27","author":"M Chehade","year":"2024","unstructured":"Chehade M, Dellon ES, Spergel JM, et al. Dupilumab for Eosinophilic Esophagitis in patients 1 to 11 years of age. N Engl J Med. 2024;27(24):2239\u201351.","journal-title":"N Engl J Med"}],"updated-by":[{"DOI":"10.1186\/s12887-026-07870-8","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:00:00Z","timestamp":1794009600000}}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-024-05313-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12887-024-05313-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-024-05313-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T04:17:17Z","timestamp":1794025037000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12887-024-05313-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,5]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5313"],"URL":"https:\/\/doi.org\/10.1186\/s12887-024-05313-w","relation":{},"ISSN":["1471-2431"],"issn-type":[{"value":"1471-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,5]]},"assertion":[{"value":"31 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original article has been updated: Author name and affiliation has been updated for Naglaa M Kamal.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2026","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s12887-026-07870-8","URL":"https:\/\/doi.org\/10.1186\/s12887-026-07870-8","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by The Ethics Committee of King Abdullah International Medical Research Center approved this study (NRJ21J\/186\/09).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. Consent is not unnecessary according to national regulation (Ethics Committee KAIMRC) because this research is retrospective study.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"100"}}