{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:16:40Z","timestamp":1772165800716,"version":"3.50.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570466"],"award-info":[{"award-number":["81570466"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"DOI":"10.1186\/s12887-025-05977-y","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T04:44:33Z","timestamp":1754541873000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["First case report in China of Gitelman syndrome associated with ileocecal polyps in a child: a case report"],"prefix":"10.1186","volume":"25","author":[{"given":"Yue","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"5977_CR1","first-page":"221","volume":"79","author":"HJ Gitelman","year":"1966","unstructured":"Gitelman HJ, Graham JB, Welt LG. A new familial disorder characterized by hypokalemia and hypomagnesemia. Trans Assoc Am Physicians. 1966;79:221\u201335.","journal-title":"Trans Assoc Am Physicians"},{"issue":"1","key":"5977_CR2","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/ng0196-24","volume":"12","author":"DB Simon","year":"1996","unstructured":"Simon DB, Nelson-Williams C, Bia MJ, et al. Gitelman\u2019s variant of Bartter\u2019s syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat Genet. 1996;12(1):24\u201330. https:\/\/doi.org\/10.1038\/ng0196-24.","journal-title":"Nat Genet"},{"issue":"9","key":"5977_CR3","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.1002\/ajmg.a.62885","volume":"188","author":"R Rossanti","year":"2022","unstructured":"Rossanti R, Horinouchi T, Sakakibara N, et al. Detecting pathogenic deep intronic variants in Gitelman syndrome. Am J Med Genet A. 2022;188(9):2576\u201383. https:\/\/doi.org\/10.1002\/ajmg.a.62885.","journal-title":"Am J Med Genet A"},{"issue":"09","key":"5977_CR4","doi-asserted-by":"publisher","first-page":"712","DOI":"10.3760\/cma.j.issn.0578-1426.2017.09.021","volume":"56","author":"Gitelman Syndrome Collaborative Study Group","year":"2017","unstructured":"Gitelman Syndrome Collaborative Study Group. Expert consensus for the diagnosis and treatment of patients with Gitelman syndrome. Chin J Intern Med. 2017;56(09):712\u20136. https:\/\/doi.org\/10.3760\/cma.j.issn.0578-1426.2017.09.021.","journal-title":"Chin J Intern Med"},{"issue":"1","key":"5977_CR5","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.kint.2016.09.046","volume":"91","author":"A Blanchard","year":"2017","unstructured":"Blanchard A, Bockenhauer D, Bolignano D, et al. Gitelman syndrome: consensus and guidance from a kidney disease: improving global outcomes (KDIGO) controversies conference. Kidney Int. 2017;91(1):24\u201333. https:\/\/doi.org\/10.1016\/j.kint.2016.09.046.","journal-title":"Kidney Int"},{"issue":"2","key":"5977_CR6","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/0022-3468(68)90001-8","volume":"3","author":"JH Louw","year":"1968","unstructured":"Louw JH. Polypoid lesions of the large bowel in children with particular reference to benign lymphoid polyposis. J Pediatr Surg. 1968;3(2):195\u2013209. https:\/\/doi.org\/10.1016\/0022-3468(68)90001-8.","journal-title":"J Pediatr Surg"},{"issue":"10","key":"5977_CR7","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1016\/j.jpedsurg.2012.05.024","volume":"47","author":"C Wei","year":"2012","unstructured":"Wei C, Dayong W, Liqun J, Xiaoman W, Yu W, Xiaohong Q. Colorectal polyps in children: a retrospective study of clinical features and the value of ultrasonography in their diagnosis. J Pediatr Surg. 2012;47(10):1853\u20138. https:\/\/doi.org\/10.1016\/j.jpedsurg.2012.05.024.","journal-title":"J Pediatr Surg"},{"issue":"5","key":"5977_CR8","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/S1875-9572(09)60063-2","volume":"50","author":"LC Wang","year":"2009","unstructured":"Wang LC, Lee HC, Yeung CY, Chan WT, Jiang CB. Gastrointestinal polyps in children. Pediatr Neonatol. 2009;50(5):196\u2013201. https:\/\/doi.org\/10.1016\/S1875-9572(09)60063-2.","journal-title":"Pediatr Neonatol"},{"issue":"06","key":"5977_CR9","doi-asserted-by":"publisher","first-page":"566","DOI":"10.3760\/cma.j.issn.1673-4408.2012.06.007","volume":"39","author":"ZHANG Li-na","year":"2012","unstructured":"Li-na ZHANG. PAN jian,jin yu. Progress of colorectal juvenile polyps in children. Int J Pediatr. 2012;39(06):566\u20138. https:\/\/doi.org\/10.3760\/cma.j.issn.1673-4408.2012.06.007.","journal-title":"Int J Pediatr"},{"issue":"1","key":"5977_CR10","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1159\/000163047","volume":"18","author":"MT Haghi Ashtiani","year":"2009","unstructured":"Haghi Ashtiani MT, Monajemzadeh M, Motamed F, et al. Colorectal polyps: a clinical, endoscopic and pathologic study in Iranian children. Med Princ Pract. 2009;18(1):53\u20136. https:\/\/doi.org\/10.1159\/000163047.","journal-title":"Med Princ Pract"},{"issue":"5","key":"5977_CR11","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3393\/jksc.2010.26.5.365","volume":"26","author":"HJ Kim","year":"2010","unstructured":"Kim HJ, Kang MK, Lee HS, Kim DS, Lee DH. Signet ring cell carcinoma arising from a solitary juvenile polyp in the colon. J Korean Soc Coloproctol. 2010;26(5):365\u20137. https:\/\/doi.org\/10.3393\/jksc.2010.26.5.365.","journal-title":"J Korean Soc Coloproctol"},{"issue":"2","key":"5977_CR12","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s13691-022-00593-4","volume":"12","author":"Y Tanaka","year":"2023","unstructured":"Tanaka Y, Muramatsu M, Miyauchi Y, Suzuki Y, Morohashi T, Nozu K. A case of advanced breast cancer with Gitelman syndrome. Int Cancer Conf J. 2023;12(2):137\u201342. https:\/\/doi.org\/10.1007\/s13691-022-00593-4.","journal-title":"Int Cancer Conf J"},{"key":"5977_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41525-020-00146-9","volume":"5","author":"JY Chan","year":"2020","unstructured":"Chan JY, Toh MR, Chong ST, et al. Multiple neoplasia in a patient with Gitelman syndrome harboring germline monoallelic MUTYH mutation. NPJ Genom Med. 2020;5: 39. https:\/\/doi.org\/10.1038\/s41525-020-00146-9.","journal-title":"NPJ Genom Med"},{"issue":"3","key":"5977_CR14","doi-asserted-by":"publisher","first-page":"e70323","DOI":"10.1002\/ccr3.70323","volume":"13","author":"MD Hussen","year":"2025","unstructured":"Hussen MD, Rezwana F, Ony MI, Sultana F, Joba FA, Tabassum Z. Rare case of Adult-Onset Gitelman syndrome in a patient with multiple comorbidities: A case report. Clin Case Rep. 2025;13(3):e70323. https:\/\/doi.org\/10.1002\/ccr3.70323. Published 2025 Mar 14.","journal-title":"Clin Case Rep"},{"issue":"3","key":"5977_CR15","first-page":"255","volume":"20","author":"B Liu","year":"2017","unstructured":"Liu B. [Correlation between chronic constipation and colorectal neoplasms]. Zhonghua Wei Chang Wai Ke Za Zhi. 2017;20(3):255\u20137. Chinese. PMID: 28338155.","journal-title":"Zhonghua Wei Chang Wai Ke Za Zhi"},{"issue":"2","key":"5977_CR16","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1006\/bbrc.1996.0893","volume":"223","author":"H Chang","year":"1996","unstructured":"Chang H, Tashiro K, Hirai M, Ikeda K, Kurokawa K, Fujita T. Identification of a cDNA encoding a thiazide-sensitive sodium-chloride cotransporter from the human and its mRNA expression in various tissues. Biochem Biophys Res Commun. 1996;223(2):324\u20138. https:\/\/doi.org\/10.1006\/bbrc.1996.0893.","journal-title":"Biochem Biophys Res Commun"},{"key":"5977_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1405503","volume":"15","author":"Z Yan","year":"2024","unstructured":"Yan Z, Zheng H, Feng J, et al. Causal links between circulatory inflammatory cytokines and risk of digestive polyps: a Mendelian randomization analysis. Front Pharmacol. 2024;15: 1405503. https:\/\/doi.org\/10.3389\/fphar.2024.1405503.","journal-title":"Front Pharmacol"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-025-05977-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12887-025-05977-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-025-05977-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T04:44:35Z","timestamp":1754541875000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpediatr.biomedcentral.com\/articles\/10.1186\/s12887-025-05977-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,7]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5977"],"URL":"https:\/\/doi.org\/10.1186\/s12887-025-05977-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6604860\/v1","asserted-by":"object"}]},"ISSN":["1471-2431"],"issn-type":[{"value":"1471-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,7]]},"assertion":[{"value":"6 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was in compliance with the Helsinki Declaration and was approved by the Ethical Review Board of Wuhan Children\u2019s Hospital (Approval Number:2024R035-E01). Written informed consent to participate in this study was provided by the participants and legal guardian of kin.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consents were obtained from the parents and the participants for the publication of this study. The parents and the participants consented to the publication of the case and any accompanying images with written consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"604"}}