{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:52:23Z","timestamp":1791478343795,"version":"4.3.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":87,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"DOI":"10.1186\/s12887-026-07288-2","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:59:25Z","timestamp":1783940365000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neonatal sepsis in Ethiopia: unveiling the persistent burden through systematic review and meta-analysis"],"prefix":"10.1186","volume":"26","author":[{"given":"Mucheye","family":"Gizachew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teshiwal","family":"Deress","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"7288_CR1","unstructured":"Federal Ministry of Health of Ethiopia. Neonatal Intensive Care Unit (NICU) Training Participants\u2019 Manual. FMoHE.https:\/\/wwwcourseherocom accessed in August 2025. 2014."},{"issue":"1","key":"7288_CR2","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1186\/s12887-023-04399-y","volume":"23","author":"M Sherif","year":"2023","unstructured":"Sherif M, Abera D, Desta K. Prevalence and antibiotic resistance pattern of bacteria from sepsis suspected neonates at St. Paul\u2019s Hospital Millennium Medical College, Addis Ababa, Ethiopia. BMC Pediatr. 2023;23(1):575.","journal-title":"BMC Pediatr"},{"issue":"10063","key":"7288_CR3","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1016\/S0140-6736(16)31593-8","volume":"388","author":"L Liu","year":"2016","unstructured":"Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, et al. Global, regional, and National causes of under-5 mortality in 2000\u201315: an updated systematic analysis with implications for the sustainable development goals. Lancet. 2016;388(10063):3027\u201335.","journal-title":"Lancet"},{"issue":"2","key":"7288_CR4","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/s41390-021-01696-z","volume":"91","author":"IH Celik","year":"2022","unstructured":"Celik IH, Hanna M, Canpolat FE, Pammi M. Diagnosis of neonatal sepsis: the past, present and future. Pediatr Res. 2022;91(2):337\u201350.","journal-title":"Pediatr Res"},{"issue":"8","key":"7288_CR5","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/S1473-3099(14)70804-7","volume":"14","author":"AC Seale","year":"2014","unstructured":"Seale AC, Blencowe H, Manu AA, Nair H, Bahl R, Qazi SA, et al. Estimates of possible severe bacterial infection in neonates in sub-Saharan Africa, South Asia, and Latin America for 2012: a systematic review and meta-analysis. Lancet Infect Dis. 2014;14(8):731\u201341.","journal-title":"Lancet Infect Dis"},{"issue":"RR\u201310","key":"7288_CR6","first-page":"1","volume":"59","author":"JR Verani","year":"2010","unstructured":"Verani JR, McGee L, Schrag SJ. Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC). Prevention of perinatal group B streptococcal disease\u2013revised guidelines from CDC, 2010. 2010;59(RR-10): PMID. MMWR Recomm Rep. 2010;59(RR\u201310):1\u201336.","journal-title":"MMWR Recomm Rep"},{"issue":"3","key":"7288_CR7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s40138-019-00188-z","volume":"7","author":"M Ershad","year":"2019","unstructured":"Ershad M, Mostafa A, Dela Cruz M, Vearrier D. Neonatal Sepsis. Curr Emerg Hosp Med Rep. 2019;7(3):83\u201390.","journal-title":"Curr Emerg Hosp Med Rep"},{"key":"7288_CR8","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.2147\/IDR.S203454","volume":"13","author":"C Carreras-Abad","year":"2020","unstructured":"Carreras-Abad C, Ramkhelawon L, Heath PT, Le Doare KA. Vaccine Against Group B, Streptococcus. Recent advances. Infect Drug Resist. 2020;13:1263\u201372.","journal-title":"Infect Drug Resist"},{"key":"7288_CR9","volume-title":"Global Report on the epidemiology and burden on sepsis: current evidence, identifying gaps and future directions","author":"A Cassini","year":"2020","unstructured":"Cassini A, Allegranzi B, Fleischmann-Struzek C, Kortz T, Markwart R, Saito H, et al. Global Report on the epidemiology and burden on sepsis: current evidence, identifying gaps and future directions. Geneva: Other World Health Organization Tuncalp Mingard, \u00d6zge.; 2020."},{"issue":"3","key":"7288_CR10","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.jhin.2017.06.023","volume":"97","author":"E Sanderson","year":"2017","unstructured":"Sanderson E, Yeo KT, Wang AY, Callander I, Bajuk B, Bolisetty S, et al. Dwell time and risk of central-line-associated bloodstream infection in neonates. J Hosp Infect. 2017;97(3):267\u201374.","journal-title":"J Hosp Infect"},{"issue":"1","key":"7288_CR11","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1128\/CMR.00031-13","volume":"27","author":"KA Simonsen","year":"2014","unstructured":"Simonsen KA, Anderson-Berry AL, Delair SF, Davies HD. Early-onset neonatal sepsis. Clin Microbiol Rev. 2014;27(1):21\u201347.","journal-title":"Clin Microbiol Rev"},{"key":"7288_CR12","doi-asserted-by":"publisher","first-page":"709","DOI":"10.2147\/JMDH.S260058","volume":"13","author":"BB Masaba","year":"2020","unstructured":"Masaba BB, Mmusi-Phetoe RM. Neonatal Survival in Sub-Sahara: A Review of Kenya and South Africa. J Multidiscip Healthc. 2020;13:709\u201316.","journal-title":"J Multidiscip Healthc"},{"key":"7288_CR13","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1186\/1471-2458-13-483","volume":"13","author":"Y Mekonnen","year":"2013","unstructured":"Mekonnen Y, Tensou B, Telake DS, Degefie T, Bekele A. Neonatal mortality in Ethiopia: trends and determinants. BMC Public Health. 2013;13:413.","journal-title":"BMC Public Health"},{"key":"7288_CR14","unstructured":"EPHI ICF. August. Ethiopia Mini Demographic and Health Survey 2019: Final Report. 2021. Available at: https:\/\/dhsprogramcom\/pubs\/pdf\/FR363\/FR363pdf. Accessed in 2025."},{"key":"7288_CR15","doi-asserted-by":"publisher","first-page":"6468492","DOI":"10.1155\/2020\/6468492","volume":"2020","author":"MA Assemie","year":"2020","unstructured":"Assemie MA, Alene M, Yismaw L, Ketema DB, Lamore Y, Petrucka P, et al. Prevalence of Neonatal Sepsis in Ethiopia: A Systematic Review and Meta-Analysis. Int J Pediatr. 2020;2020:6468492.","journal-title":"Int J Pediatr"},{"key":"7288_CR16","unstructured":"Federal Ministry of Health (FMoH). Ethiopia Health Sector Transformation Plan II (HSTP II). 2021."},{"key":"7288_CR17","unstructured":"World Health Organization. Ethiopia Health Profile; Ethiopian Public Health Institute (EPHI) & ICF. (2019). 2023."},{"key":"7288_CR18","unstructured":"Statoids. Ethiopia Demographic and Health Survey 2016\/2019; Regions of Ethiopia. 2026. Retrieved from ( https:\/\/www.statoids.org )."},{"key":"7288_CR19","unstructured":"Fitzgerald P. Ethiopia regions map [Map]. Wikimedia Commons. Licensed under CC BY-SA 3.0. 2008."},{"key":"7288_CR20","doi-asserted-by":"publisher","first-page":"b2700","DOI":"10.1136\/bmj.b2700","volume":"339","author":"A Liberati","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J, Mulrow C, G\u00f8tzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700.","journal-title":"BMJ"},{"issue":"1","key":"7288_CR21","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/s13643-019-1153-y","volume":"8","author":"M Feldmann","year":"2019","unstructured":"Feldmann M, Ullrich C, Bataillard C, Knirsch W, Gosteli-Peter MA, Latal B, et al. Neurocognitive outcome of school-aged children with congenital heart disease who underwent cardiopulmonary bypass surgery: a systematic review protocol. Syst Rev. 2019;8(1):236.","journal-title":"Syst Rev"},{"issue":"3","key":"7288_CR22","doi-asserted-by":"publisher","first-page":"123","DOI":"10.15171\/ijhpm.2014.71","volume":"3","author":"Z Munn","year":"2014","unstructured":"Munn Z, Moola S, Riitano D, Lisy K. The development of a critical appraisal tool for use in systematic reviews addressing questions of prevalence. Int J Health Policy Manage. 2014;3(3):123\u20138.","journal-title":"Int J Health Policy Manage"},{"issue":"4","key":"7288_CR23","doi-asserted-by":"publisher","first-page":"351","DOI":"10.4236\/ojn.2012.24052","volume":"2","author":"B Chikuse","year":"2012","unstructured":"Chikuse B, Chirwa E, Maluwa A, Malata A, Odland J. Midwives\u2019 adherence to guidelines on the management of birth asphyxia in Malawi. Open J Nurs. 2012;2(4):351\u20137.","journal-title":"Open J Nurs"},{"key":"7288_CR24","unstructured":"Wells G. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analysis. 2004. https:\/\/ciniiacjp\/naid\/10020590649\/. Accessed in july 2025."},{"issue":"9","key":"7288_CR25","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.jclinepi.2011.11.014","volume":"65","author":"D Hoy","year":"2012","unstructured":"Hoy D, Brooks P, Woolf A, Blyth F, March L, Bain C, et al. Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement. J Clin Epidemiol. 2012;65(9):934\u20139.","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"7288_CR26","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1471-2288-8-79","volume":"8","author":"G Rucker","year":"2008","unstructured":"Rucker G, Schwarzer G, Carpenter JR, Schumacher M. Undue reliance on I2 in assessing heterogeneity may mislead. BMC Med Res Methodol. 2008;8(1):79.","journal-title":"BMC Med Res Methodol"},{"issue":"2","key":"7288_CR27","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1002\/jrsm.12","volume":"1","author":"M Borenstein","year":"2010","unstructured":"Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synthesis Methods. 2010;1(2):97\u2013111.","journal-title":"Res Synthesis Methods"},{"key":"7288_CR28","first-page":"184205","volume":"11","author":"T Mezgebu","year":"2022","unstructured":"Mezgebu T, Ossabo G, Zekiwos A, Mohammed H, Demisse Z. Neonatal sepsis and its associated factors among neonates admitted to the neonatal intensive care unit in Wachemo University Comprehensive Specialized Hospital, Southern Ethiopia, 2022. Front Pediatr. 2022;11:184205.","journal-title":"Front Pediatr"},{"issue":"1","key":"7288_CR29","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s12887-025-05515-w","volume":"25","author":"MM Ali","year":"2025","unstructured":"Ali MM, Kwatra G, Mengistu M, Kijineh B, Hailemeriam T, Worku E, et al. Trends of neonatal sepsis and its etiology at Hawassa, Ethiopia: a five year retrospective cross-sectional study. BMC Pediatr. 2025;25(1):152.","journal-title":"BMC Pediatr"},{"key":"7288_CR30","doi-asserted-by":"publisher","first-page":"4169","DOI":"10.2147\/IDR.S374835","volume":"15","author":"E Birrie","year":"2022","unstructured":"Birrie E, Sisay E, Tibebu NS, Tefera BD, Zeleke M, Tefera Z. Neonatal Sepsis and Associated Factors Among Newborns in Woldia and Dessie Comprehensive Specialized Hospitals, North-East Ethiopia, 2021. Infect Drug Resist. 2022;15:4169\u201379.","journal-title":"Infect Drug Resist"},{"key":"7288_CR31","doi-asserted-by":"publisher","unstructured":"Wondie WA, Wubneh CA, Bruck T, Legesse B, Tamre S, Tamir Y, et al. Incidence of early neonatal sepsis and its predictor among low birthweight neonates in Northwest Ethiopia Comprehensive Specialized Hospitals, A retrospective follow-up study, 2024. J Neonatal Nurs. 2025;31(3):101636. https:\/\/doi.org\/10.1016\/j.jnn.2025.101636.","DOI":"10.1016\/j.jnn.2025.101636"},{"key":"7288_CR32","doi-asserted-by":"publisher","unstructured":"Mustefa A, Abera A, Aseffa A, Abathun T, Degefa N, Tadesse H, Yeheyis T. Prevalence of neonatal sepsis and associated factors amongst neonates admitted in Arbaminch General Hospital, Arbaminch, Southern Ethiopia, 2019. J Pediatr Neonatal Care. 2020;10(1):1\u20137. https:\/\/doi.org\/10.15406\/jpnc.2020.10.00410.","DOI":"10.15406\/jpnc.2020.10.00410"},{"key":"7288_CR33","doi-asserted-by":"publisher","unstructured":"Sorsa A. Epidemiology of neonatal sepsis and associated factors implicated: Observational study at Neonatal Intensive Care Unit of Arsi University Teaching and Referral Hospital, South East Ethiopia. Ethiopian Journal of Health Sciences, 2019;29(3):333\u2013342 https:\/\/doi.org\/10.4314\/ejhs.v29i3.5.","DOI":"10.4314\/ejhs.v29i3.5"},{"key":"7288_CR34","doi-asserted-by":"publisher","unstructured":"Agnche Z, Yeshita HY, & Gonete KA. Neonatal sepsis and its associated factors among neonates admitted to neonatal intensive care units in primary hospitals in Central Gondar Zone, Northwest Ethiopia, 2019. Infection and Drug Resistance, 2020;13:3957\u20133967. https:\/\/doi.org\/10.2147\/IDR.S276678.","DOI":"10.2147\/IDR.S276678"},{"key":"7288_CR35","doi-asserted-by":"publisher","unstructured":"Jamie AH, Bekele K, Bekele F, Edosa D, Mekonnen M, Benayew M. Magnitude and associated factors of neonatal sepsis among neonates admitted to neonatal intensive care unit of Northern Oromia hospitals, Ethiopia: A multicenter cross-sectional study. Ann Med Surg (Lond). 2022;78:103782. https:\/\/doi.org\/10.1016\/j.amsu.2021.103782.\u00a0 PMID: 35620038; PMCID: PMC9127159.","DOI":"10.1016\/j.amsu.2021.103782"},{"key":"7288_CR36","doi-asserted-by":"publisher","unstructured":"Mamo M, Ketema E, Miskir D, Hussen S, Boti N. Determinants of neonatal sepsis among neonates admitted in a neonatal intensive care unit at Jinka General Hospital, Southern Ethiopia. Int J Nurs Midwifery. 2019;11(3):18\u201324. https:\/\/doi.org\/10.5897\/IJNM2018.0335.","DOI":"10.5897\/IJNM2018.0335"},{"key":"7288_CR37","doi-asserted-by":"publisher","unstructured":"Bayana B, Tadesse H, Alemu M, Worku T, Abate A. Prevalence and predictors of neonatal sepsis among neonates admitted to neonatal intensive care units in public hospitals of Addis Ababa, Ethiopia. PLoS One. 2020;15(10):e0239450. https:\/\/doi.org\/10.1371\/journal.pone.0239450.","DOI":"10.1371\/journal.pone.0239450"},{"key":"7288_CR38","doi-asserted-by":"publisher","unstructured":"Roble AK, Ayehubizu LM, Olad HM. Neonatal sepsis and associated factors among neonates admitted to neonatal intensive care unit in general hospitals, Eastern Ethiopia. Clin Med Insights Pediatr. 2022;16:11795565221098346. https:\/\/doi.org\/10.1177\/11795565221098346.","DOI":"10.1177\/11795565221098346"},{"key":"7288_CR39","doi-asserted-by":"publisher","unstructured":"Worku E, Fenta DA, Mo M. Bacterial etiology and risk factors among newborns suspected of sepsis at Hawassa, Ethiopia. Sci Rep. 2022;12:20148. https:\/\/doi.org\/10.1038\/s41598-022-24277-8.","DOI":"10.1038\/s41598-022-24277-8"},{"key":"7288_CR40","doi-asserted-by":"publisher","unstructured":"Bekele D, Shiferaw G, Tesfaye A, Abebe T, Alemu M. Bacterial profile, antimicrobial susceptibility pattern, and associated factors of neonatal sepsis among neonates admitted to neonatal intensive care units in selected hospitals of Ethiopia. Infect Drug Resist. 2022;15:5319\u20135329. https:\/\/doi.org\/10.2147\/IDR.S379097.","DOI":"10.2147\/IDR.S379097"},{"key":"7288_CR41","doi-asserted-by":"publisher","unstructured":"Nur H, Osman M. Neonatal sepsis and associated factors among neonates admitted to public hospitals in Eastern Ethiopia. Pediatr Health Med Ther. 2021;12:47\u201355. https:\/\/doi.org\/10.2147\/PHMT.S293456.","DOI":"10.2147\/PHMT.S293456"},{"key":"7288_CR42","doi-asserted-by":"publisher","unstructured":"Etafa W, Fetensa G, Tsegaye R, Wakuma B, Sundararajan V, Bayisa G, Turi E. Neonatal sepsis risk factors in public hospitals in Wollega zones, Ethiopia: case-control study. PAMJ One Health. 2022;7:2. https:\/\/doi.org\/10.11604\/pamj-oh.2022.7.2.27310.","DOI":"10.11604\/pamj-oh.2022.7.2.27310"},{"key":"7288_CR43","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12887-022-03824-y","volume":"23","author":"TY Akalu","year":"2023","unstructured":"Akalu TY, Aynalem YA, Shiferaw WS, Desta M, Amha H, Getaneh D, et al. Prevalence and determinants of early onset neonatal sepsis at two selected public referral hospitals in the Northwest Ethiopia: a cross-sectional study. BMC Pediatr. 2023;23:10.","journal-title":"BMC Pediatr"},{"key":"7288_CR44","doi-asserted-by":"publisher","unstructured":"Akalu TY, Gebremichael B, Desta KW, Aynalem YA, Shiferaw WS, Alamneh YM. Predictors of neonatal sepsis in public referral hospitals, Northwest Ethiopia: A case control study. PLoS One. 2020;15(6):e0234472. https:\/\/doi.org\/10.1371\/journal.pone.0234472.","DOI":"10.1371\/journal.pone.0234472"},{"key":"7288_CR45","doi-asserted-by":"publisher","unstructured":"Mezgebu T, Ossabo G, Zekiwos A, Mohammed H, Demisse Z. Neonatal sepsis and its associated factors among neonates admitted to the neonatal intensive care unit in Wachemo University Comprehensive Specialized Hospital, Southern Ethiopia, 2022. Front Pediatr. 2023;11:1184205. https:\/\/doi.org\/10.3389\/fped.2023.1184205.","DOI":"10.3389\/fped.2023.1184205"},{"key":"7288_CR46","doi-asserted-by":"publisher","unstructured":"Najjar N, Abeje G, Alemu M, Tadesse H, Worku T, Abate A. Risk prediction of healthcare-associated neonatal sepsis in Amhara, Ethiopia: A prospective cohort study. Glob Pediatr. 2025;13:100268. https:\/\/doi.org\/10.1016\/j.gpeds.2025.100268.","DOI":"10.1016\/j.gpeds.2025.100268"},{"key":"7288_CR47","doi-asserted-by":"publisher","first-page":"1272193","DOI":"10.3389\/fpubh.2024.1272193","volume":"12","author":"FB Traor\u00e9","year":"2024","unstructured":"Traor\u00e9 FB, Sidib\u00e9 CS, Diallo EHM, Camara BS, Sidib\u00e9 S, Diallo A, et al. Prevalence and factors associated with maternal and neonatal sepsis in sub-Saharan Africa: a systematic review and meta-analysis. Front Public Health. 2024;12:1272193.","journal-title":"Front Public Health"},{"issue":"5","key":"7288_CR48","doi-asserted-by":"publisher","first-page":"e661","DOI":"10.1016\/S2214-109X(22)00043-2","volume":"10","author":"R Milton","year":"2022","unstructured":"Milton R, Gillespie D, Dyer C, Taiyari K, Carvalho MJ, Thomson K, et al. Neonatal sepsis and mortality in low-income and middle-income countries from a facility-based birth cohort: an international multisite prospective observational study. Lancet Glob Health. 2022;10(5):e661\u201372.","journal-title":"Lancet Glob Health"},{"key":"7288_CR49","doi-asserted-by":"publisher","unstructured":"Okube OT, Komen M. Prevalence and Predictors of Neonatal Sepsis among Neonates Admitted at the Newborn Unit of Kenyatta National Hospital, Nairobi, Kenya. > 10 9. Open J Obstet Gynecol. 2020;10(9)1216\u20131232. https:\/\/doi.org\/10.4236\/ojog.2020.1090114.","DOI":"10.4236\/ojog.2020.1090114"},{"issue":"9","key":"7288_CR50","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1007\/s00038-020-01489-x","volume":"55","author":"BB Abate","year":"2020","unstructured":"Abate BB, Kasie AM, Reta MA, Kassaw MW. Neonatal sepsis and its associated factors in East Africa: a systematic review and meta-analysis. Int J Public Health. 2020;55(9):1623\u201333.","journal-title":"Int J Public Health"},{"key":"7288_CR51","doi-asserted-by":"publisher","unstructured":"Najjar N, Gobezayehu AG, Hopkins J, Biza H, Yakubu H, Denny L et al. Risk prediction of healthcare-associated neonatal sepsis in Amhara, Ethiopia: A prospective cohort study. Glob Pediatr. 2025;13:100268. https:\/\/doi.org\/10.1016\/j.gpeds.2025.100268.","DOI":"10.1016\/j.gpeds.2025.100268"},{"issue":"2","key":"7288_CR52","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1097\/MS9.0000000000001619","volume":"86","author":"A Eyeberu","year":"2023","unstructured":"Eyeberu A, Musa I, Debella A. Neonatal sepsis and its predictors in Ethiopia: umbrella reviews of a systematic review and meta-analysis. Ann Med Surg (Lond). 2023;86(2):994\u20131002.","journal-title":"Ann Med Surg (Lond)"},{"key":"7288_CR53","unstructured":"World Health Organization. Survive and Thrive: Transforming Care of Every Small and Sick Newborn. https:\/\/www.who.int \u203a Publications. 2019: Accessed on 22 Sept 2025."},{"issue":"1","key":"7288_CR54","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12887-020-1949-x","volume":"20","author":"A Belachew","year":"2020","unstructured":"Belachew A, Tewabe T. Neonatal sepsis and its association with birth weight and gestational age among admitted neonates in Ethiopia: systematic review and meta-analysis. BMC Pediatr. 2020;20(1):55.","journal-title":"BMC Pediatr"},{"issue":"7","key":"7288_CR55","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1097\/INF.0000000000004364","volume":"43","author":"M Gashaw","year":"2024","unstructured":"Gashaw M, Ali S, Berhane M, Tesfaw G, Eshetu B, Workneh N, et al. Neonatal Sepsis Due to Multidrug-resistant Bacteria at a Tertiary Teaching Hospital in Ethiopia. Pediatr Infect Dis. 2024;43(7):687\u201393.","journal-title":"Pediatr Infect Dis"},{"key":"7288_CR56","doi-asserted-by":"publisher","first-page":"1461689","DOI":"10.3389\/fmicb.2024.1461689","volume":"15","author":"T Deress","year":"2024","unstructured":"Deress T, Belay G, Ayenew G, Ferede W, Worku M, Feleke T, et al. Bacterial profiles and their antibiotic susceptibility patterns in neonatal sepsis at the University of Gondar Comprehensive Specialized Hospital, Ethiopia. Front Microbiol. 2024;15:1461689.","journal-title":"Front Microbiol"},{"key":"7288_CR57","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1186\/s12887-023-04399-y","volume":"23","author":"M Sherif","year":"2023","unstructured":"Sherif M, Abera D, Desta K. Prevalence and antibiotic resistance pattern of bacteria from sepsis suspected neonates at St. Paul\u2019s Hospital Millennium Medical College, Addis Abab, Ethiopia. BMC Pediatr. 2023;23:575.","journal-title":"BMC Pediatr"},{"issue":"1","key":"7288_CR58","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3390\/antibiotics14010006","volume":"14","author":"C Kariniotaki","year":"2024","unstructured":"Kariniotaki C, Thomou C, Gkentzi D, Panteris E, Dimitriou G, Hatzidaki E. Neonatal Sepsis: A Comprehensive Review. Antibiot (Basel). 2024;14(1):6.","journal-title":"Antibiot (Basel)"},{"issue":"7414","key":"7288_CR59","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JP Higgins","year":"2003","unstructured":"Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557\u201360.","journal-title":"BMJ"},{"key":"7288_CR60","doi-asserted-by":"publisher","unstructured":"Geissb\u00fchler M, Hincapi\u00e9 CA, Aghlmandi S, Zwahlen M, J\u00fcni P, da Costa BR. Most published meta-regression analyses based on aggregate data suffer from methodological pitfalls: a meta-epidemiological study. BMC Med Res Methodol. 2021;21(1):123. https:\/\/doi.org\/10.1186\/s12874-021-01331-2.","DOI":"10.1186\/s12874-021-01331-2"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12887-026-07288-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-026-07288-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-026-07288-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:03:28Z","timestamp":1791475408000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12887-026-07288-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7288"],"URL":"https:\/\/doi.org\/10.1186\/s12887-026-07288-2","relation":{},"ISSN":["1471-2431"],"issn-type":[{"value":"1471-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]},"assertion":[{"value":"28 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"964"}}