{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:04:02Z","timestamp":1790723042104,"version":"4.1.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control & Prevention","doi-asserted-by":"publisher","award":["2016-NG62001-00"],"award-info":[{"award-number":["2016-NG62001-00"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control & Prevention","doi-asserted-by":"publisher","award":["2017-NI62001-00"],"award-info":[{"award-number":["2017-NI62001-00"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control & Prevention","doi-asserted-by":"publisher","award":["2016-ER6203-00"],"award-info":[{"award-number":["2016-ER6203-00"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Psychiatry"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12888-019-2174-8","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T15:02:39Z","timestamp":1560956559000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of plasma endothelial lipase levels on cognitive impairment"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3166-4187","authenticated-orcid":false,"given":"Sang-Moon","family":"Yun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee-Yun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Won","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihyun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,19]]},"reference":[{"issue":"8","key":"2174_CR1","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.bbalip.2010.05.004","volume":"1801","author":"P Foley","year":"2010","unstructured":"Foley P. Lipids in Alzheimer's disease: a century-old story. Biochim Biophys Acta. 2010;1801(8):750\u20133.","journal-title":"Biochim Biophys Acta"},{"issue":"4\u20135","key":"2174_CR2","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.neuropharm.2010.01.005","volume":"59","author":"KR Bales","year":"2010","unstructured":"Bales KR. Brain lipid metabolism, apolipoprotein E and the pathophysiology of Alzheimer's disease. Neuropharmacology. 2010;59(4\u20135):295\u2013302.","journal-title":"Neuropharmacology"},{"issue":"4","key":"2174_CR3","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1007\/s13311-014-0295-9","volume":"11","author":"R Guerreiro","year":"2014","unstructured":"Guerreiro R, Hardy J. Genetics of Alzheimer's disease. Neurotherapeutics. 2014;11(4):732\u20137.","journal-title":"Neurotherapeutics"},{"key":"2174_CR4","unstructured":"International Genomics of Alzheimer's Disease C. Convergent genetic and expression data implicate immunity in Alzheimer's disease. Alzheimers Dement. 2015;11(6):658\u201371."},{"issue":"2","key":"2174_CR5","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1212\/01.WNL.0000070182.02537.84","volume":"61","author":"MA Pappolla","year":"2003","unstructured":"Pappolla MA, Bryant-Thomas TK, Herbert D, Pacheco J, Fabra Garcia M, Manjon M, Girones X, Henry TL, Matsubara E, Zambon D, et al. Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology. Neurology. 2003;61(2):199\u2013205.","journal-title":"Neurology"},{"issue":"8","key":"2174_CR6","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1212\/WNL.57.8.1447","volume":"57","author":"LJ Launer","year":"2001","unstructured":"Launer LJ, White LR, Petrovitch H, Ross GW, Curb JD. Cholesterol and neuropathologic markers of AD: a population-based autopsy study. Neurology. 2001;57(8):1447\u201352.","journal-title":"Neurology"},{"issue":"11","key":"2174_CR7","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1212\/WNL.0b013e31822e145d","volume":"77","author":"T Matsuzaki","year":"2011","unstructured":"Matsuzaki T, Sasaki K, Hata J, Hirakawa Y, Fujimi K, Ninomiya T, Suzuki SO, Kanba S, Kiyohara Y, Iwaki T. Association of Alzheimer disease pathology with abnormal lipid metabolism: the Hisayama study. Neurology. 2011;77(11):1068\u201375.","journal-title":"Neurology"},{"issue":"1","key":"2174_CR8","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3233\/JAD-160826","volume":"56","author":"KJ Anstey","year":"2017","unstructured":"Anstey KJ, Ashby-Mitchell K, Peters R. Updating the evidence on the association between serum cholesterol and risk of late-life dementia: review and meta-analysis. J Alzheimers Dis. 2017;56(1):215\u201328.","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"2174_CR9","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/ana.24326","volume":"77","author":"KL Rasmussen","year":"2015","unstructured":"Rasmussen KL, Tybjaerg-Hansen A, Nordestgaard BG, Frikke-Schmidt R. Plasma levels of apolipoprotein E and risk of dementia in the general population. Ann Neurol. 2015;77(2):301\u201311.","journal-title":"Ann Neurol"},{"issue":"12","key":"2174_CR10","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1001\/archneurol.2010.297","volume":"67","author":"C Reitz","year":"2010","unstructured":"Reitz C, Tang MX, Schupf N, Manly JJ, Mayeux R, Luchsinger JA. Association of higher levels of high-density lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer disease. Arch Neurol. 2010;67(12):1491\u20137.","journal-title":"Arch Neurol"},{"issue":"1","key":"2174_CR11","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1097\/MOL.0000000000000257","volume":"27","author":"M Koch","year":"2016","unstructured":"Koch M, Jensen MK. HDL-cholesterol and apolipoproteins in relation to dementia. Curr Opin Lipidol. 2016;27(1):76\u201387.","journal-title":"Curr Opin Lipidol"},{"issue":"6","key":"2174_CR12","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1007\/s10519-010-9407-4","volume":"40","author":"M Gatz","year":"2010","unstructured":"Gatz M, Reynolds CA, Finkel D, Pedersen NL, Walters E. Dementia in Swedish twins: predicting incident cases. Behav Genet. 2010;40(6):768\u201375.","journal-title":"Behav Genet"},{"issue":"5 Suppl","key":"2174_CR13","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1016\/j.jalz.2012.09.001","volume":"8","author":"MM Mielke","year":"2012","unstructured":"Mielke MM, Montine T, Khachaturian AS. Vascular diseases: one pathway toward new conceptual models of dementia. Alzheimers Dement. 2012;8(5 Suppl):S69\u201370.","journal-title":"Alzheimers Dement"},{"issue":"6","key":"2174_CR14","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1373\/clinchem.2009.142810","volume":"56","author":"WG Miller","year":"2010","unstructured":"Miller WG, Myers GL, Sakurabayashi I, Bachmann LM, Caudill SP, Dziekonski A, Edwards S, Kimberly MM, Korzun WJ, Leary ET, et al. Seven direct methods for measuring HDL and LDL cholesterol compared with ultracentrifugation reference measurement procedures. Clin Chem. 2010;56(6):977\u201386.","journal-title":"Clin Chem"},{"issue":"4","key":"2174_CR15","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.jacl.2011.05.004","volume":"5","author":"JH Contois","year":"2011","unstructured":"Contois JH, Warnick GR, Sniderman AD. Reliability of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B measurement. J Clin Lipidol. 2011;5(4):264\u201372.","journal-title":"J Clin Lipidol"},{"issue":"3","key":"2174_CR16","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1172\/JCI200317744","volume":"111","author":"JC Cohen","year":"2003","unstructured":"Cohen JC. Endothelial lipase: direct evidence for a role in HDL metabolism. J Clin Invest. 2003;111(3):318\u201321.","journal-title":"J Clin Invest"},{"issue":"4","key":"2174_CR17","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1161\/01.RES.0000205846.46812.be","volume":"98","author":"W Ahmed","year":"2006","unstructured":"Ahmed W, Orasanu G, Nehra V, Asatryan L, Rader DJ, Ziouzenkova O, Plutzky J. High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion. Circ Res. 2006;98(4):490\u20138.","journal-title":"Circ Res"},{"issue":"2","key":"2174_CR18","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/ana.10265","volume":"52","author":"R Schmidt","year":"2002","unstructured":"Schmidt R, Schmidt H, Curb JD, Masaki K, White LR, Launer LJ. Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia aging study. Ann Neurol. 2002;52(2):168\u201374.","journal-title":"Ann Neurol"},{"issue":"3","key":"2174_CR19","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1172\/JCI16146","volume":"111","author":"W Jin","year":"2003","unstructured":"Jin W, Millar JS, Broedl U, Glick JM, Rader DJ. Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo. J Clin Invest. 2003;111(3):357\u201362.","journal-title":"J Clin Invest"},{"issue":"3","key":"2174_CR20","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1172\/JCI16306","volume":"111","author":"T Ishida","year":"2003","unstructured":"Ishida T, Choi S, Kundu RK, Hirata K, Rubin EM, Cooper AD, Quertermous T. Endothelial lipase is a major determinant of HDL level. J Clin Invest. 2003;111(3):347\u201355.","journal-title":"J Clin Invest"},{"issue":"11","key":"2174_CR21","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1161\/01.CIR.0000028423.07623.6A","volume":"106","author":"AS deLemos","year":"2002","unstructured":"deLemos AS, Wolfe ML, Long CJ, Sivapackianathan R, Rader DJ. Identification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol. Circulation. 2002;106(11):1321\u20136.","journal-title":"Circulation"},{"issue":"1","key":"2174_CR22","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1161\/CIRCGENETICS.111.962613","volume":"6","author":"RR Singaraja","year":"2013","unstructured":"Singaraja RR, Sivapalaratnam S, Hovingh K, Dube MP, Castro-Perez J, Collins HL, Adelman SJ, Riwanto M, Manz J, Hubbard B, et al. The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans. Circ Cardiovasc Genet. 2013;6(1):54\u201362.","journal-title":"Circ Cardiovasc Genet"},{"issue":"5","key":"2174_CR23","doi-asserted-by":"publisher","first-page":"2748","DOI":"10.1073\/pnas.0438039100","volume":"100","author":"K Ma","year":"2003","unstructured":"Ma K, Cilingiroglu M, Otvos JD, Ballantyne CM, Marian AJ, Chan L. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci U S A. 2003;100(5):2748\u201353.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"2174_CR24","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/S0008-6363(03)00287-6","volume":"58","author":"H Azumi","year":"2003","unstructured":"Azumi H, Hirata K, Ishida T, Kojima Y, Rikitake Y, Takeuchi S, Inoue N, Kawashima S, Hayashi Y, Itoh H, et al. Immunohistochemical localization of endothelial cell-derived lipase in atherosclerotic human coronary arteries. Cardiovasc Res. 2003;58(3):647\u201354.","journal-title":"Cardiovasc Res"},{"issue":"4","key":"2174_CR25","doi-asserted-by":"publisher","first-page":"192","DOI":"10.5551\/jat.E502","volume":"14","author":"T Yasuda","year":"2007","unstructured":"Yasuda T, Hirata K, Ishida T, Kojima Y, Tanaka H, Okada T, Quertermous T, Yokoyama M. Endothelial lipase is increased by inflammation and promotes LDL uptake in macrophages. J Atheroscler Thromb. 2007;14(4):192\u2013201.","journal-title":"J Atheroscler Thromb"},{"issue":"52","key":"2174_CR26","doi-asserted-by":"publisher","first-page":"54032","DOI":"10.1074\/jbc.M411112200","volume":"279","author":"Y Kojma","year":"2004","unstructured":"Kojma Y, Hirata K, Ishida T, Shimokawa Y, Inoue N, Kawashima S, Quertermous T, Yokoyama M. Endothelial lipase modulates monocyte adhesion to the vessel wall. A potential role in inflammation. J Biol Chem. 2004;279(52):54032\u20138.","journal-title":"J Biol Chem"},{"issue":"6","key":"2174_CR27","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1161\/01.RES.0000064502.47539.6D","volume":"92","author":"W Jin","year":"2003","unstructured":"Jin W, Sun GS, Marchadier D, Octtaviani E, Glick JM, Rader DJ. Endothelial cells secrete triglyceride lipase and phospholipase activities in response to cytokines as a result of endothelial lipase. Circ Res. 2003;92(6):644\u201350.","journal-title":"Circ Res"},{"issue":"3","key":"2174_CR28","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1001\/archneur.56.3.303","volume":"56","author":"RC Petersen","year":"1999","unstructured":"Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999;56(3):303\u20138.","journal-title":"Arch Neurol"},{"issue":"3","key":"2174_CR29","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011;7(3):263\u20139.","journal-title":"Alzheimers Dement"},{"issue":"7","key":"2174_CR30","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.3346\/jkms.2010.25.7.1071","volume":"25","author":"HJ Ahn","year":"2010","unstructured":"Ahn HJ, Chin J, Park A, Lee BH, Suh MK, Seo SW, Na DL. Seoul neuropsychological screening battery-dementia version (SNSB-D): a useful tool for assessing and monitoring cognitive impairments in dementia patients. J Korean Med Sci. 2010;25(7):1071\u20136.","journal-title":"J Korean Med Sci"},{"issue":"5","key":"2174_CR31","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/S1474-4422(11)70077-1","volume":"10","author":"H Barthel","year":"2011","unstructured":"Barthel H, Gertz HJ, Dresel S, Peters O, Bartenstein P, Buerger K, Hiemeyer F, Wittemer-Rump SM, Seibyl J, Reininger C, et al. Cerebral amyloid-beta PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study. Lancet Neurol. 2011;10(5):424\u201335.","journal-title":"Lancet Neurol"},{"issue":"3","key":"2174_CR32","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3233\/JAD-161139","volume":"57","author":"HJ Kim","year":"2017","unstructured":"Kim HJ, Cho H, Werring DJ, Jang YK, Kim YJ, Lee JS, Lee J, Jun S, Park S, Ryu YH, et al. 18F-AV-1451 PET imaging in three patients with probable cerebral amyloid Angiopathy. J Alzheimers Dis. 2017;57(3):711\u20136.","journal-title":"J Alzheimers Dis"},{"key":"2174_CR33","first-page":"1250","volume":"58","author":"G Farrar","year":"2017","unstructured":"Farrar G. Regional visual read inspection of [18F] flutemetamol brain images from end-of-life and amnestic MCI subjects. J Nuclear Med. 2017;58:1250.","journal-title":"J Nuclear Med"},{"issue":"2","key":"2174_CR34","doi-asserted-by":"publisher","first-page":"e22","DOI":"10.1371\/journal.pmed.0030022","volume":"3","author":"KO Badellino","year":"2006","unstructured":"Badellino KO, Wolfe ML, Reilly MP, Rader DJ. Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis. PLoS Med. 2006;3(2):e22.","journal-title":"PLoS Med"},{"issue":"11","key":"2174_CR35","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1038\/mp.2011.147","volume":"17","author":"BC Stephan","year":"2012","unstructured":"Stephan BC, Hunter S, Harris D, Llewellyn DJ, Siervo M, Matthews FE, Brayne C. The neuropathological profile of mild cognitive impairment (MCI): a systematic review. Mol Psychiatry. 2012;17(11):1056\u201376.","journal-title":"Mol Psychiatry"},{"issue":"4","key":"2174_CR36","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/mp.2016.101","volume":"22","author":"N Amin","year":"2017","unstructured":"Amin N, Jovanova O, Adams HH, Dehghan A, Kavousi M, Vernooij MW, Peeters RP, de Vrij FM, van der Lee SJ, van Rooij JG, et al. Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms. Mol Psychiatry. 2017;22(4):537\u201343.","journal-title":"Mol Psychiatry"},{"issue":"1","key":"2174_CR37","doi-asserted-by":"crossref","first-page":"196 e191","DOI":"10.1016\/j.neurobiolaging.2010.05.024","volume":"33","author":"TN van den Kommer","year":"2012","unstructured":"van den Kommer TN, Dik MG, Comijs HC, Jonker C, Deeg DJ. Role of lipoproteins and inflammation in cognitive decline: do they interact? Neurobiol Aging. 2012;33(1):196 e191\u201312.","journal-title":"Neurobiol Aging"},{"issue":"8","key":"2174_CR38","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1161\/ATVBAHA.108.163998","volume":"28","author":"A Singh-Manoux","year":"2008","unstructured":"Singh-Manoux A, Gimeno D, Kivimaki M, Brunner E, Marmot MG. Low HDL cholesterol is a risk factor for deficit and decline in memory in midlife: the Whitehall II study. Arterioscler Thromb Vasc Biol. 2008;28(8):1556\u201362.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"2174_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034078","volume":"7","author":"F Song","year":"2012","unstructured":"Song F, Poljak A, Crawford J, Kochan NA, Wen W, Cameron B, Lux O, Brodaty H, Mather K, Smythe GA, et al. Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals. PLoS One. 2012;7(6):e34078.","journal-title":"PLoS One"},{"issue":"6","key":"2174_CR40","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/nrn3880","volume":"16","author":"FL Heppner","year":"2015","unstructured":"Heppner FL, Ransohoff RM, Becher B. Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci. 2015;16(6):358\u201372.","journal-title":"Nat Rev Neurosci"},{"key":"2174_CR41","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3389\/fnins.2015.00173","volume":"9","author":"G van Dijk","year":"2015","unstructured":"van Dijk G, van Heijningen S, Reijne AC, Nyakas C, van der Zee EA, Eisel UL. Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration. Front Neurosci. 2015;9:173.","journal-title":"Front Neurosci"},{"issue":"2","key":"2174_CR42","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.autrev.2011.09.005","volume":"11","author":"F Sardi","year":"2011","unstructured":"Sardi F, Fassina L, Venturini L, Inguscio M, Guerriero F, Rolfo E, Ricevuti G. Alzheimer's disease, autoimmunity and inflammation. The good, the bad and the ugly. Autoimmun Rev. 2011;11(2):149\u201353.","journal-title":"Autoimmun Rev"},{"key":"2174_CR43","first-page":"171","volume":"6","author":"S Takeda","year":"2014","unstructured":"Takeda S, Sato N, Morishita R. Systemic inflammation, blood-brain barrier vulnerability and cognitive\/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy. Front Aging Neurosci. 2014;6:171.","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"2174_CR44","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/alzrt118","volume":"4","author":"P Eikelenboom","year":"2012","unstructured":"Eikelenboom P, Hoozemans JJ, Veerhuis R, van Exel E, Rozemuller AJ, van Gool WA. Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease. Alzheimers Res Ther. 2012;4(3):15.","journal-title":"Alzheimers Res Ther"},{"issue":"1","key":"2174_CR45","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3233\/JAD-132681","volume":"41","author":"R Alonso","year":"2014","unstructured":"Alonso R, Pisa D, Marina AI, Morato E, Rabano A, Carrasco L. Fungal infection in patients with Alzheimer's disease. J Alzheimers Dis. 2014;41(1):301\u201311.","journal-title":"J Alzheimers Dis"},{"key":"2174_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/srep15015","volume":"5","author":"D Pisa","year":"2015","unstructured":"Pisa D, Alonso R, Rabano A, Rodal I, Carrasco L. Different brain regions are infected with Fungi in Alzheimer's disease. Sci Rep. 2015;5:15015.","journal-title":"Sci Rep"},{"issue":"3","key":"2174_CR47","doi-asserted-by":"publisher","first-page":"957","DOI":"10.3233\/JAD-140621","volume":"43","author":"P Maheshwari","year":"2015","unstructured":"Maheshwari P, Eslick GD. Bacterial infection and Alzheimer's disease: a meta-analysis. J Alzheimers Dis. 2015;43(3):957\u201366.","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"2174_CR48","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.neuron.2018.06.030","volume":"99","author":"WA Eimer","year":"2018","unstructured":"Eimer WA, Vijaya Kumar DK, Navalpur Shanmugam NK, Rodriguez AS, Mitchell T, Washicosky KJ, Gyorgy B, Breakefield XO, Tanzi RE, Moir RD. Alzheimer's disease-associated beta-amyloid is rapidly seeded by Herpesviridae to protect against brain infection. Neuron. 2018;99(1):56\u201363 e53.","journal-title":"Neuron"},{"issue":"2","key":"2174_CR49","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3233\/JAD-142853","volume":"48","author":"SA Harris","year":"2015","unstructured":"Harris SA, Harris EA. Herpes simplex virus type 1 and other pathogens are key causative factors in sporadic Alzheimer's disease. J Alzheimers Dis. 2015;48(2):319\u201353.","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"2174_CR50","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.sdentj.2011.10.006","volume":"24","author":"A Al-Rasheed","year":"2012","unstructured":"Al-Rasheed A. Elevation of white blood cells and platelet counts in patients having chronic periodontitis. Saudi Dental J. 2012;24(1):17\u201321.","journal-title":"Saudi Dental J"},{"issue":"12","key":"2174_CR51","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1111\/j.1524-6175.2005.04809.x","volume":"7","author":"A Jesri","year":"2005","unstructured":"Jesri A, Okonofua EC, Egan BM. Platelet and white blood cell counts are elevated in patients with the metabolic syndrome. J Clin Hypertens. 2005;7(12):705\u201311 quiz 712-703.","journal-title":"J Clin Hypertens"},{"issue":"5","key":"2174_CR52","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1161\/CIRCULATIONAHA.107.707349","volume":"117","author":"KO Badellino","year":"2008","unstructured":"Badellino KO, Wolfe ML, Reilly MP, Rader DJ. Endothelial lipase is increased in vivo by inflammation in humans. Circulation. 2008;117(5):678\u201385.","journal-title":"Circulation"},{"issue":"12","key":"2174_CR53","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.1194\/jlr.P600002-JLR200","volume":"47","author":"ME Paradis","year":"2006","unstructured":"Paradis ME, Badellino KO, Rader DJ, Deshaies Y, Couture P, Archer WR, Bergeron N, Lamarche B. Endothelial lipase is associated with inflammation in humans. J Lipid Res. 2006;47(12):2808\u201313.","journal-title":"J Lipid Res"},{"issue":"2","key":"2174_CR54","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.atherosclerosis.2008.03.012","volume":"198","author":"SW Shiu","year":"2008","unstructured":"Shiu SW, Tan KC, Huang Y, Wong Y. Type 2 diabetes mellitus and endothelial lipase. Atherosclerosis. 2008;198(2):441\u20137.","journal-title":"Atherosclerosis"},{"issue":"12","key":"2174_CR55","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1016\/j.neurobiolaging.2005.10.007","volume":"27","author":"D Galimberti","year":"2006","unstructured":"Galimberti D, Fenoglio C, Lovati C, Venturelli E, Guidi I, Corra B, Scalabrini D, Clerici F, Mariani C, Bresolin N, et al. Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer's disease. Neurobiol Aging. 2006;27(12):1763\u20138.","journal-title":"Neurobiol Aging"},{"issue":"5","key":"2174_CR56","doi-asserted-by":"publisher","first-page":"466","DOI":"10.15252\/emmm.201506123","volume":"8","author":"M Suarez-Calvet","year":"2016","unstructured":"Suarez-Calvet M, Kleinberger G, Araque Caballero MA, Brendel M, Rominger A, Alcolea D, Fortea J, Lleo A, Blesa R, Gispert JD, et al. sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers. EMBO molecular medicine. 2016;8(5):466\u201376.","journal-title":"EMBO molecular medicine"},{"issue":"9","key":"2174_CR57","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1136\/jnnp.74.9.1200","volume":"74","author":"E Tarkowski","year":"2003","unstructured":"Tarkowski E, Andreasen N, Tarkowski A, Blennow K. Intrathecal inflammation precedes development of Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2003;74(9):1200\u20135.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"10","key":"2174_CR58","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1194\/jlr.M600510-JLR200","volume":"48","author":"G Qiu","year":"2007","unstructured":"Qiu G, Hill JS. Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages. J Lipid Res. 2007;48(10):2112\u201322.","journal-title":"J Lipid Res"},{"issue":"2","key":"2174_CR59","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1093\/cvr\/cvp419","volume":"87","author":"Y Kojima","year":"2010","unstructured":"Kojima Y, Ishida T, Sun L, Yasuda T, Toh R, Rikitake Y, Fukuda A, Kume N, Koshiyama H, Taniguchi A, et al. Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo. Cardiovasc Res. 2010;87(2):385\u201393.","journal-title":"Cardiovasc Res"},{"issue":"1","key":"2174_CR60","first-page":"1","volume":"33","author":"JE Yu","year":"2018","unstructured":"Yu JE, Han SY, Wolfson B, Zhou Q. The role of endothelial lipase in lipid metabolism, inflammation, and cancer. Histol Histopathol. 2018;33(1):1\u201310.","journal-title":"Histol Histopathol"},{"issue":"1","key":"2174_CR61","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/jpm8010003","volume":"8","author":"Ram\u00f3n Cacabelos","year":"2018","unstructured":"Cacabelos R, Meyyazhagan A, Carril JC, Cacabelos P, Teijido O. Pharmacogenetics of vascular risk factors in Alzheimer's disease. Journal of personalized medicine. 2018;8(1).","journal-title":"Journal of Personalized Medicine"}],"container-title":["BMC Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12888-019-2174-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12888-019-2174-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12888-019-2174-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T23:08:39Z","timestamp":1592435319000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/10.1186\/s12888-019-2174-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,19]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["2174"],"URL":"https:\/\/doi.org\/10.1186\/s12888-019-2174-8","relation":{},"ISSN":["1471-244X"],"issn-type":[{"value":"1471-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,19]]},"assertion":[{"value":"16 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study has been approved by institutional review boards from Samsung medical center, Korea. All written informed consents were obtained from patients and caregivers.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"187"}}