{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:50:56Z","timestamp":1769111456396,"version":"3.49.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Psychiatry"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>A diagnosis of dementia in middle-aged and elder people is often complicated by physical frailty and comorbid neuropsychiatric symptoms (NPSs). Previous studies have identified NPSs as a risk factor for dementia. The aim of this study was to figure out to what extent individual NPS and certain demographic factors increased the risk of dementia in middle-aged and senior psychiatric inpatients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>One hundred twenty-seven middle-aged and senior patients admitted to psychiatric wards for late-onset (age\u2009\u2265\u200950\u2009years) psychiatric symptoms were included and categorized into dementia or non-demented psychiatric disorders (NDPD). The patients\u2019 demographic information and medical records were collected during the first hospitalization and subjected to statistical analyses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>41.73% of the registered psychiatric inpatients were diagnosed as dementia in which Alzheimer\u2019s disease (AD) was the dominant subtype. The NDPD group consisted of nine individual diagnoses, except for schizophrenia. The frequencies of dementia inpatients increased with first episode age while that of NDPD inpatients decreased with first episode age. In the enrolled inpatients, most of dementia patients were males while females accounted for a higher proportion of NDPD patients. 58.49% of enrolled dementia inpatients presented cognitive deficit (CD) as the initial symptom while the remaining 41.51% showed NPS as initial symptom. Of the 12 NPSs, agitation and apathy greatly and significantly increased risk of dementia in psychiatric inpatients with late-onset psychiatric symptoms.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>These results added evidence that the demented patients admitted to psychiatric ward are more likely to be male, older first episode age, and have characteristic NPS including aberrant motor behavior (AMB), hallucinations, agitation, irritability and apathy. Further, this study emphasized the importance of agitation and apathy of NPSs functioning as risk factors of dementia in these inpatients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12888-021-03210-5","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T09:03:58Z","timestamp":1619600638000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Agitation and apathy increase risk of dementia in psychiatric inpatients with late-onset psychiatric symptoms"],"prefix":"10.1186","volume":"21","author":[{"given":"Yuan","family":"Shao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xijian","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"issue":"3","key":"3210_CR1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer\u2019s Dement. 2011;7(3):263\u20139. https:\/\/doi.org\/10.1016\/j.jalz.2011.03.005.","journal-title":"Alzheimer\u2019s Dement"},{"issue":"4","key":"3210_CR2","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1080\/09540260802099968","volume":"20","author":"C Ballard","year":"2008","unstructured":"Ballard C, Day S, Sharp S, Wing G, Sorensen S, et al. Int Rev Psychiatry (Abingdon). 2008;20(4):396\u2013404.","journal-title":"Int Rev Psychiatry (Abingdon)"},{"issue":"6","key":"3210_CR3","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1159\/000339954","volume":"33","author":"CE Fischer","year":"2012","unstructured":"Fischer CE, Ismail Z, Schweizer TA. Delusions increase functional impairment in Alzheimer's disease. Dement Geriatr Cogn Disord. 2012;33(6):393\u20139. https:\/\/doi.org\/10.1159\/000339954.","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"5","key":"3210_CR4","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/gps.2550","volume":"26","author":"K Karttunen","year":"2011","unstructured":"Karttunen K, Karppi P, Hiltunen A, Vanhanen M, V\u00e4lim\u00e4ki T, Martikainen J, et al. Neuropsychiatric symptoms and quality of life in patients with very mild and mild Alzheimer's disease. Int J Geriatr Psychiatry. 2011;26(5):473\u201382. https:\/\/doi.org\/10.1002\/gps.2550.","journal-title":"Int J Geriatr Psychiatry"},{"issue":"5","key":"3210_CR5","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1176\/appi.ajp.2014.14040480","volume":"172","author":"ME Peters","year":"2015","unstructured":"Peters ME, Schwartz S, Han D, Rabins PV, Steinberg M, Tschanz JT, et al. Neuropsychiatric symptoms as predictors of progression to severe Alzheimer's dementia and death: the Cache County dementia progression study. Am J Psychiatry. 2015;172(5):460\u20135. https:\/\/doi.org\/10.1176\/appi.ajp.2014.14040480.","journal-title":"Am J Psychiatry"},{"issue":"11","key":"3210_CR6","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.jagp.2013.01.049","volume":"21","author":"ME Peters","year":"2013","unstructured":"Peters ME, Rosenberg PB, Steinberg M, Norton MC, Welsh-Bohmer KA, Hayden KM, et al. Neuropsychiatric symptoms as risk factors for progression from CIND to dementia: the Cache County study. Am J Geriatr Psychiatry. 2013;21(11):1116\u201324. https:\/\/doi.org\/10.1016\/j.jagp.2013.01.049.","journal-title":"Am J Geriatr Psychiatry"},{"issue":"7","key":"3210_CR7","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.jagp.2013.01.006","volume":"21","author":"PB Rosenberg","year":"2013","unstructured":"Rosenberg PB, Mielke MM, Appleby BS, Oh ES, Geda YE, Lyketsos CG. The association of neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease. Am J Geriatr Psychiatry. 2013;21(7):685\u201395. https:\/\/doi.org\/10.1016\/j.jagp.2013.01.006.","journal-title":"Am J Geriatr Psychiatry"},{"issue":"3","key":"3210_CR8","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.3233\/JAD-180119","volume":"65","author":"AR Sutin","year":"2018","unstructured":"Sutin AR, Stephan Y, Terracciano A. Psychological distress, self-beliefs, and risk of cognitive impairment and dementia. J Alzheimers Dis. 2018;65(3):1041\u201350. https:\/\/doi.org\/10.3233\/JAD-180119.","journal-title":"J Alzheimers Dis"},{"key":"3210_CR9","doi-asserted-by":"crossref","unstructured":"Reynolds, Chandra, A., Petkus, Andrew, J., Kremen, William, S., Wetherell: Temporal Dynamics of Cognitive Performance and Anxiety Across Older Adulthood. Psychol Aging 2017;32(3):278\u201392. https:\/\/doi.org\/10.1037\/pag0000164.","DOI":"10.1037\/pag0000164"},{"issue":"4","key":"3210_CR10","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.jalz.2015.09.008","volume":"12","author":"AJ Petkus","year":"2016","unstructured":"Petkus AJ, Reynolds CA, Wetherell JL, Kremen WS, Pedersen NL, Gatz M. Anxiety is associated with increased risk of dementia in older Swedish twins. Alzheimers Dement. 2016;12(4):399\u2013406. https:\/\/doi.org\/10.1016\/j.jalz.2015.09.008.","journal-title":"Alzheimers Dement"},{"issue":"4","key":"3210_CR11","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1590\/S1980-57642009DN20400004","volume":"2","author":"F Taragano","year":"2008","unstructured":"Taragano F, Allegri R, Lyketsos C. Mild behavioral impairment: a prodromal stage of dementia. Dementia Neuropsychol. 2008;2(4):256\u201360. https:\/\/doi.org\/10.1590\/S1980-57642009DN20400004.","journal-title":"Dementia Neuropsychol"},{"issue":"2","key":"3210_CR12","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jalz.2015.05.017","volume":"12","author":"Z Ismail","year":"2016","unstructured":"Ismail Z, Smith EE, Geda Y, Sultzer D, Brodaty H, Smith G, et al. Neuropsychiatric symptoms as early manifestations of emergent dementia: provisional diagnostic criteria for mild behavioral impairment. Alzheimers Dement. 2016;12(2):195\u2013202. https:\/\/doi.org\/10.1016\/j.jalz.2015.05.017.","journal-title":"Alzheimers Dement"},{"issue":"1\u20132","key":"3210_CR13","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1159\/000074277","volume":"17","author":"CG Lyketsos","year":"2004","unstructured":"Lyketsos CG, Lee HB. Diagnosis and treatment of depression in Alzheimer's disease. A practical update for the clinician. Dement Geriatr Cogn Disord. 2004;17(1\u20132):55\u201364. https:\/\/doi.org\/10.1159\/000074277.","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"1","key":"3210_CR14","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/j.1532-5415.2005.00575_11.x","volume":"54","author":"CJ Sch\u00f6lzel-Dorenbos","year":"2006","unstructured":"Sch\u00f6lzel-Dorenbos CJ. Mild behavioral impairment: a prodromal stage of frontotemporal lobar degeneration. J Am Geriatr Soc. 2006;54(1):180\u20131. https:\/\/doi.org\/10.1111\/j.1532-5415.2005.00575_11.x.","journal-title":"J Am Geriatr Soc"},{"issue":"53","key":"3210_CR15","first-page":"165","volume":"14","author":"J Butman","year":"2003","unstructured":"Butman J, Taragano F, Allegri R. Neuropsychological tools for the study of depression. Vertex (Buenos Aires). 2003;14(53):165\u201378.","journal-title":"Vertex (Buenos Aires)"},{"issue":"1","key":"3210_CR16","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3233\/JAD-170632","volume":"62","author":"FE Taragano","year":"2018","unstructured":"Taragano FE, Allegri RF, Heisecke SL, Martelli MI, Feldman ML, S\u00e1nchez V, et al. Risk of conversion to dementia in a mild behavioral impairment group compared to a psychiatric group and to a mild cognitive impairment group. J Alzheimers Dis. 2018;62(1):227\u201338. https:\/\/doi.org\/10.3233\/JAD-170632.","journal-title":"J Alzheimers Dis"},{"issue":"12","key":"3210_CR17","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","volume":"89","author":"IG Mckeith","year":"2017","unstructured":"Mckeith IG, Boeve BF, Dickson DW, Halliday G, Kosaka K. Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB consortium. Neurology. 2017;89(12):88\u2013100. https:\/\/doi.org\/10.1212\/WNL.0000000000004058.","journal-title":"Neurology"},{"key":"3210_CR18","doi-asserted-by":"crossref","unstructured":"Coyle-Gilchrist ITS, Dick KM, Patterson K, Vazquez Rodriquez P, Wehmann E,Wilcox A, Lansdall CJ, Dawson KE, Wiggins J, Mead S: Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes. Neurology 2016;86(18):1736\u201343. https:\/\/doi.org\/10.1212\/WNL.0000000000002638.","DOI":"10.1212\/WNL.0000000000002638"},{"issue":"1","key":"3210_CR19","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3233\/JAD-2008-14110","volume":"14","author":"KA Jellinger","year":"2008","unstructured":"Jellinger KA. The pathology of \u201cvascular dementia\u201d: a critical update. J Alzheimers Dis. 2008;14(1):107\u201323. https:\/\/doi.org\/10.3233\/JAD-2008-14110.","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"3210_CR20","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","volume":"7","author":"MS Albert","year":"2011","unstructured":"Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011;7(3):270\u20139. https:\/\/doi.org\/10.1016\/j.jalz.2011.03.008.","journal-title":"Alzheimers Dement"},{"issue":"2","key":"3210_CR21","doi-asserted-by":"publisher","first-page":"487","DOI":"10.3233\/JAD-160119","volume":"53","author":"H Li","year":"2016","unstructured":"Li H, Jia J, Yang Z. Mini-mental state examination in elderly Chinese: a population-based normative study. J Alzheimers Dis. 2016;53(2):487\u201396. https:\/\/doi.org\/10.3233\/JAD-160119.","journal-title":"J Alzheimers Dis"},{"issue":"4","key":"3210_CR22","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/j.1532-5415.1995.tb05811.x","volume":"43","author":"P Chen","year":"1995","unstructured":"Chen P, Yu ES, Zhang M, Liu WT, Hill R, Katzman R. ADL dependence and medical conditions in Chinese older persons: a population-based survey in Shanghai, China. J Am Geriatr Soc. 1995;43(4):378\u201383. https:\/\/doi.org\/10.1111\/j.1532-5415.1995.tb05811.x.","journal-title":"J Am Geriatr Soc"},{"issue":"12","key":"3210_CR23","doi-asserted-by":"publisher","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","volume":"44","author":"JL Cummings","year":"1994","unstructured":"Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994;44(12):2308\u201314. https:\/\/doi.org\/10.1212\/WNL.44.12.2308.","journal-title":"Neurology"},{"issue":"5 Suppl 6","key":"3210_CR24","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1212\/WNL.48.5_Suppl_6.10S","volume":"48","author":"JL Cummings","year":"1997","unstructured":"Cummings JL. The neuropsychiatric inventory: assessing psychopathology in dementia patients. Neurology. 1997;48(5 Suppl 6):S10\u20136. https:\/\/doi.org\/10.1212\/WNL.48.5_Suppl_6.10S.","journal-title":"Neurology"},{"issue":"3","key":"3210_CR25","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1097\/00019442-199808000-00002","volume":"6","author":"J Webster","year":"1998","unstructured":"Webster J, Grossberg GT. Late-life onset of psychotic symptoms. Am J Geriatr Psychiatry. 1998;6(3):196\u2013202. https:\/\/doi.org\/10.1097\/00019442-199808000-00002.","journal-title":"Am J Geriatr Psychiatry"},{"issue":"1\u20132","key":"3210_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jns.2008.03.006","volume":"270","author":"KA Jellinger","year":"2008","unstructured":"Jellinger KA. Morphologic diagnosis of \u201cvascular dementia\u201d - a critical update. J Neurol Sci. 2008;270(1\u20132):1\u201312. https:\/\/doi.org\/10.1016\/j.jns.2008.03.006.","journal-title":"J Neurol Sci"},{"issue":"5","key":"3210_CR27","doi-asserted-by":"publisher","first-page":"375","DOI":"10.2165\/11533100-000000000-00000","volume":"24","author":"GD Rabinovici","year":"2010","unstructured":"Rabinovici GD, Miller BL. Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management. CNS drugs. 2010;24(5):375\u201398. https:\/\/doi.org\/10.2165\/11533100-000000000-00000.","journal-title":"CNS drugs"},{"issue":"5","key":"3210_CR28","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1111\/j.1600-0447.2010.01552.x","volume":"122","author":"IV Vahia","year":"2010","unstructured":"Vahia IV, Palmer BW, Depp C, Fellows I, Jeste DV. Is late-onset schizophrenia a subtype of schizophrenia? Acta Psychiatr Scand. 2010;122(5):414\u201326. https:\/\/doi.org\/10.1111\/j.1600-0447.2010.01552.x.","journal-title":"Acta Psychiatr Scand"},{"key":"3210_CR29","doi-asserted-by":"publisher","unstructured":"Robert Howard, M.D., ,, Peter V. Rabins, M.D., M.P.H., ,, Mary V. Seeman, M.D., ,, Dilip V. Jeste, M.D., , and, the International Late-Onset, Schizophrenia Group: Late-Onset Schizophrenia and Very-Late-Onset Schizophrenia-Like Psychosis: An International Consensus. Am J Psychiatry 2000, 157(2):172\u2013178, doi: https:\/\/doi.org\/10.1176\/appi.ajp.157.2.172.","DOI":"10.1176\/appi.ajp.157.2.172"},{"issue":"1","key":"3210_CR30","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jalz.2012.11.007","volume":"9","author":"M Prince","year":"2013","unstructured":"Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimer\u2019s Dement. 2013;9(1):63\u201375.e62.","journal-title":"Alzheimer\u2019s Dement"},{"issue":"2","key":"3210_CR31","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0749-0690(18)30476-2","volume":"8","author":"HG Koenig","year":"1992","unstructured":"Koenig HG, Blazer DG. Epidemiology of geriatric affective disorders. Clin Geriatr Med. 1992;8(2):235\u201351. https:\/\/doi.org\/10.1016\/S0749-0690(18)30476-2.","journal-title":"Clin Geriatr Med"},{"key":"3210_CR32","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.comppsych.2016.05.005","volume":"69","author":"J Wang","year":"2016","unstructured":"Wang J, Jiang C, Chen L, Wu S, Lin J, Gao L, et al. A cross-sectional study to investigate the correlation between depression comorbid with anxiety and serum lipid levels. Compr Psychiatry. 2016;69:163\u20138. https:\/\/doi.org\/10.1016\/j.comppsych.2016.05.005.","journal-title":"Compr Psychiatry"},{"issue":"1","key":"3210_CR33","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1177\/002383099200500108","volume":"5","author":"BF O'Donnell","year":"1992","unstructured":"O'Donnell BF, Drachman DA, Barnes HJ, Peterson KE, Swearer JM, Lew RA. Incontinence and troublesome behaviors predict institutionalization in dementia. J Geriatr Psychiatry Neurol. 1992;5(1):45\u201352. https:\/\/doi.org\/10.1177\/002383099200500108.","journal-title":"J Geriatr Psychiatry Neurol"},{"issue":"10","key":"3210_CR34","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1001\/archneur.62.10.1601","volume":"62","author":"N Scarmeas","year":"2005","unstructured":"Scarmeas N, Brandt J, Albert M, Hadjigeorgiou G, Papadimitriou A, Dubois B, et al. Delusions and hallucinations are associated with worse outcome in Alzheimer disease. Arch Neurol. 2005;62(10):1601\u20138. https:\/\/doi.org\/10.1001\/archneur.62.10.1601.","journal-title":"Arch Neurol"},{"issue":"4","key":"3210_CR35","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1111\/jgs.12730","volume":"62","author":"HC Kales","year":"2014","unstructured":"Kales HC, Gitlin LN, Lyketsos CG. Management of neuropsychiatric symptoms of dementia in clinical settings: recommendations from a multidisciplinary expert panel. J Am Geriatr Soc. 2014;62(4):762\u20139. https:\/\/doi.org\/10.1111\/jgs.12730.","journal-title":"J Am Geriatr Soc"},{"issue":"12","key":"3210_CR36","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1001\/jama.288.12.1475","volume":"288","author":"CG Lyketsos","year":"2002","unstructured":"Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, DeKosky S. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA. 2002;288(12):1475\u201383. https:\/\/doi.org\/10.1001\/jama.288.12.1475.","journal-title":"JAMA"},{"key":"3210_CR37","doi-asserted-by":"crossref","unstructured":"Quante A, Sulejmani A: Prevalence and Pharmacotherapy of Behavioral and Psychological Symptoms of Dementia in a Geriatric Psychiatry Unit: A Retrospective Analysis. Prim Care Companion CNS Disord.2017;19(4):17m02137. https:\/\/doi.org\/10.4088\/PCC.17m02137.","DOI":"10.4088\/PCC.17m02137"},{"issue":"2","key":"3210_CR38","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.archger.2008.09.002","volume":"49","author":"P Tagariello","year":"2009","unstructured":"Tagariello P, Girardi P, Amore M. Depression and apathy in dementia: same syndrome or different constructs? A critical review. Arch Gerontol Geriatr. 2009;49(2):246\u20139. https:\/\/doi.org\/10.1016\/j.archger.2008.09.002.","journal-title":"Arch Gerontol Geriatr"}],"container-title":["BMC Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12888-021-03210-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12888-021-03210-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12888-021-03210-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T09:07:47Z","timestamp":1619600867000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/10.1186\/s12888-021-03210-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,28]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["3210"],"URL":"https:\/\/doi.org\/10.1186\/s12888-021-03210-5","relation":{},"ISSN":["1471-244X"],"issn-type":[{"value":"1471-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,28]]},"assertion":[{"value":"27 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Shenzhen Kangning Hospital Ethics Committee approved the study design, data collection, and publication of the results. All methods were carried out in accordance with relevant guidelines and regulations. All patients were\u2009\u2265\u200918\u2009years of age and gave written, informed consents.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors confirm no conflicts of interest associated with this publication that could have influenced its outcome.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"214"}}