{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:42:46Z","timestamp":1793248966848,"version":"4.5.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Psychiatry"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Bipolar Disorder (BD) is one of the most common mental disorders associated with depressive symptoms and impairment in executive functions such as response inhibition. This study aimed to investigate the effectiveness of medication therapy combined with Transcranial Direct Current Stimulation (tDCS) on depression and response inhibition of patients with BD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      This is a double-blinded randomized clinical trial with pretest, posttest, and follow-up design. Participants were 30 patients with BD randomly assigned to two groups of Medication+tDCS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915, receiving medications plus tDCS with 2\u2009mA intensity over dorsolateral prefrontal cortex for 10\u2009days, two sessions per day each for 20\u2009min) and Medication (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915, receiving mood stabilizers including 2\u20135 tables of 300\u2009mg (mg) lithium, 200\u2009mg sodium valproate, and 200\u2009mg carbamazepine two times per day). Pretest, posttest and 3-month follow-up assessments were the 21-item Hamilton Depression Rating Scale (HDRS) and a Go\/No-Go test. Collected data were analyzed in SPSS v.20 software.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean HDRS score in both groups was reduced after both interventional techniques, where the group received combined therapy showed more reduction (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), although their effects were not maintained after 3\u2009months. In examining response inhibition variable, only the combined therapy could reduce the commission error of patients under a go\/no-go task (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), but its effect was not maintained after 3\u2009months. There was no significant difference in the group received medication therapy alone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Medication in combination with tDCS can reduce the depressive symptoms and improve the response inhibition ability of people with BD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      This study was registred by Iranian Registry of Clinical Trials (Parallel, ID:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/en.irct.ir\/trial\/45956\">IRCT20191229045931N1<\/jats:ext-link>\n                      , Registration date: 24\/08\/2020).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12888-021-03592-6","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T06:21:43Z","timestamp":1637302903000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of medication therapy combined with transcranial direct current stimulation on depression and response inhibition of patients with bipolar disorder type I: a clinical trial"],"prefix":"10.1186","volume":"21","author":[{"given":"Parnaz","family":"Mardani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Zolghadriha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Dadashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Javdani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedeh Elnaz","family":"Mousavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"issue":"8","key":"3592_CR1","doi-asserted-by":"publisher","first-page":"403","DOI":"10.3390\/medicina55080403","volume":"55","author":"P Dome","year":"2019","unstructured":"Dome P, Rihmer Z, Gonda X. 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