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Given symptomatic remission\u2019s recent emergence as a viable treatment goal, the Remission in Schizophrenia Working Group\u2019s criteria (RSWG-cr), based on eight items from the Positive and Negative Syndrome Scale (PANSS-8), are frequently used in clinical and research settings. Against that background, we sought to evaluate the PANSS-8\u2019s psychometric properties and examine the RSWG-cr\u2019s clinical validity among outpatients in Sweden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Cross-sectional register data were collected from outpatient psychosis clinics in Gothenburg, Sweden. Following confirmatory and exploratory factor analyses of PANSS-8 data (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091,744) to assess the PANSS-8\u2019s psychometric properties, internal reliability was evaluated using Cronbach\u2019s alpha. Next, 649 of the patients were classified according to the RSWG-cr and their clinical and demographic characteristics compared. Binary logistic regression was used to estimate odds ratios (OR) and assess each variable\u2019s impact on remission status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The PANSS-8 showed good reliability (\u03b1\u2009=\u2009.85), and the 3D model of psychoticism, disorganization, and negative symptoms presented the best model fit. According to the RSWG-cr, 55% of the 649 patients were in remission; they were also more likely to live independently, be employed, not smoke, not take antipsychotics, and have recently received a health interview and physical examination. Patients living independently (OR\u2009=\u20091.98), who were employed (OR\u2009=\u20091.89), who were obese (OR\u2009=\u20091.61), and who had recently received a physical examination (OR\u2009=\u20091.56) also had an increased likelihood of remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The PANSS-8 is internally reliable, and, according to the RSWG-cr, remission is associated with variables of interest for patients\u2019 recovery, including living independently and being employed. Although our findings from a large, heterogeneous sample of outpatients reflect everyday clinical practice and reinforce past observations, the directions of those relationships need to be assessed in longitudinal studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12888-023-04701-3","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T16:05:49Z","timestamp":1680019549000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Psychometric and clinical evaluation of schizophrenia remission criteria in outpatients with psychotic disorders"],"prefix":"10.1186","volume":"23","author":[{"given":"Karolina","family":"Sakinyte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Holmberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"4701_CR1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental disorders: DSM-5","author":"American Psychiatric Association","year":"2013","unstructured":"American Psychiatric Association. 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