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This study aimed to compare the levels of multiple cytokines in patients with first-episode drug-naive major depressive disorder (MDD) with or without anxiety and analyze the correlation between the level of depression or anxiety and the serum cytokine levels.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The study involved 55 patients with first-episode drug-naive MDD. To assess anxiety symptoms, the 14-item HAMA was used. MDD patients were divided into two groups: 23 MDD patients without anxiety and 32 MDD patients with anxiety. The measurement of 37 cytokines was conducted. Serum cytokine levels between patients with MDD without anxiety and anxiety were compared. In multiple linear regression models, the relationship between the group and abnormal cytokines was explored. The receiver operating characteristic (ROC) curve analysis was performed to estimate diagnostic performance of serum cytokines in discriminating MDD patients with anxiety from MDD patients without anxiety. A correlation was evaluated between the scores of HAMD or HAMA and the serum cytokine levels.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In MDD patients with anxiety, IL-17\u00a0C and CCL17 levels were significantly lower than in MDD patients without anxiety (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Multiple measurements were corrected with Benjamini-Hochberger corrections, but none of these differences persisted (all <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). The results of multiple linear regression models revealed that after controlling for other independent variables, group was not a significant independent predictor of serum IL-17\u00a0C or CCL17 (all <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). The AUC values of IL-17\u00a0C and CCL17 were 0.643 and 0.637, respectively, in discriminating MDD patients with anxiety from MDD patients without anxiety. The results of partial correlation analyses showed the scores of HAMD were negatively correlated with the IL-17\u00a0C (<jats:italic>r<\/jats:italic> = -0.314, <jats:italic>P<\/jats:italic>\u2009=\u20090.021) levels with sex as a covariate.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The findings suggest that there is a potential absence of disparity in the levels of circulating cytokines among individuals diagnosed with first-episode drug-na\u00efve MDD, regardless of the presence or absence of comorbid anxiety.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12888-024-05536-2","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T09:02:32Z","timestamp":1706864552000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cytokine profile in first-episode drug-na\u00efve major depressive disorder patients with or without anxiety"],"prefix":"10.1186","volume":"24","author":[{"given":"Jun","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingrong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"5536_CR1","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/S0140-6736(11)60602-8","volume":"379","author":"D Kupfer","year":"2012","unstructured":"Kupfer D, Frank E, Phillips M. 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