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We compared prescription opioid pain medication dispensing for patients with SZ or BD versus controls over 5\u2009years to assess dispensing trends.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This retrospective, observational study analysed US claims data from the IBM\u00ae MarketScan\u00ae Commercial and Multi-State Medicaid databases for individuals aged 18\u201364\u2009years with prevalent SZ or BD for years 2015\u20132019 compared with age- and sex-matched controls. Baseline characteristics, comorbidities, and medication use were assessed. Proportions of individuals dispensed prescription opioids chronically (ie, \u226570\u2009days over a 90-day period or\u2009\u2265\u20096 prescriptions annually) or nonchronically (\u22651 prescription, chronic definition not met) were assessed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In 2019, the Commercial and Medicaid databases contained records for 4773 and 30,179 patients with SZ and 52,780 and 63,455 patients with BD, respectively. Patients with SZ or BD had a higher prevalence of comorbidities, including pain, versus controls in each analysis year. From 2015 to 2019, among commercially insured patients with SZ, chronic opioid-dispensing proportions decreased from 6.1% (controls: 2.7%) to 2.3% (controls: 1.2%) and, for patients with BD, from 11.4% (controls: 2.7%) to 6.4% (controls: 1.6%). Chronic opioid dispensing declined in Medicaid-covered patients with SZ from 15.0% (controls: 14.7%) to 6.7% (controls: 6.0%) and, for patients with BD, from 27.4% (controls: 12.0%) to 12.4% (controls: 4.7%). Among commercially insured patients with SZ, nonchronic opioid dispensing decreased from 15.5% (controls: 16.4%) to 10.7% (controls: 11.0%) and, for patients with BD, from 26.1% (controls: 17.5%) to 20.0% (controls: 12.2%). In Medicaid-covered patients with SZ, nonchronic opioid dispensing declined from 22.5% (controls: 24.4%) to 15.1% (controls: 12.7%) and, for patients with BD, from 32.3% (controls: 25.9%) to 24.6% (controls: 13.6%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The proportions of individuals dispensed chronic or nonchronic opioid medications each year were similar between commercially and Medicaid-insured patients with SZ versus controls and were higher for patients with BD versus controls. From 2015 to 2019, the proportions of individuals who were dispensed prescription opioids chronically or nonchronically decreased for patients with SZ or BD and controls.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12888-024-05676-5","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T07:02:19Z","timestamp":1712041339000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prescription opioid dispensing patterns among patients with schizophrenia or bipolar disorder"],"prefix":"10.1186","volume":"24","author":[{"given":"Brittany D.","family":"Roy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Lally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C.","family":"Akerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Fratantonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Dana","family":"Flanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mad\u00e9","family":"Wenten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"5676_CR1","doi-asserted-by":"publisher","unstructured":"Dowell D, Haegerich TM, Chou R. 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This study was based on data from the IBM\u00ae MarketScan\u00ae Research Databases, which are limited data sets where direct identifiers have been removed. As the study did not enrol patients and the data sets used are devoid of patient identifiable information, patient consent requirements are not applicable and the study was exempt from IRB review requirements, as per the Alkermes Observation Research Review and Approval Committee policy. The protocol was approved by the Alkermes Observation Research Review and Approval Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"SCA and MW are employees of Alkermes, Inc., and may own stock\/options in the company. BDR, MAS, and JF were employees of Alkermes, Inc., at the time of this research and may own stock\/options in the company. JL, CL, and WDF are employees of Epidemiologic Research & Methods, which contracted with Alkermes, Inc., to access these data and complete these analyses.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"244"}}