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Currently, there are no validated prevention programs for OCD, highlighting a critical gap in mental health services. This study aims to develop and validate the first \u00d8CD prevention program, for at-risk adults, utilizing cognitive-behavioral therapy (CBT) and exposure response prevention (ERP) techniques.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A single-blind, randomized controlled trial comparing the \u00d8CD prevention program to a waitlist control group will be conducted. Participants, at-risk adults (18\u201365\u2005years) with subclinical OCD symptoms (OCI-R score \u2265 12), will be recruited for the study. The \u00d8CD prevention program compresise of six online group sessions incorporating CBT and ERP techniques over three modules. The primary outcomes are OCD symptom severity (measured by the Obsessive-Compulsive Inventory- revised form; OCI-R), depression symptoms (measured by the Patient Health Questionnaire; PHQ-9), and anxiety symptoms (measured by the Generalised Anxiety Disorder 7-item; GAD-7). Secondary outcomes include OCD-related beliefs, experiential avoidance, resilience, quality of life, uncertainty intolerance, automatic thoughts, and distress. Outcome measures will be collected at baseline, at completion of the intervention, and one year later (follow-up). At follow-up, we will also analyze the OCD diagnostic incidence, using the Structured Clinical Interview for DSM-5. We will employ a multivariate analysis of variance (MANOVA) to explore whether significant differences exist between groups across dependent variables. To compare the OCD incidence levels from the pre-test to the follow-up we will use the chi-squared test.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discusion<\/jats:title>\n                <jats:p>The present study may contribute novel data on the efficacy of OCD prevention approaches, leading to the development of an evidence-based OCD prevention program that could alleviate individual and societal burdens associated with OCD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>This trial was approved by the University Ethical Review Authority (937\/ 28.11.2023) at Babe\u0219-Bolyai University and is registered on clinicaltrials.gov (ID: NCT06262464).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12888-024-05791-3","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T19:02:04Z","timestamp":1715281324000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["\u00d8CD: protocol for the development and evaluation of a cognitive-behavioral prevention program for obsessive-compulsive disorder"],"prefix":"10.1186","volume":"24","author":[{"given":"Roxana A. 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The study has been approved by the University Ethical Review Authority (937\/28.11.2023). Potential protocol modifications will be described in detail on clinicaltrials.gov (ID: NCT06262464). Any modification will be informed on Clinicaltrials.gov.Regarding participants\u2019 consent, participants will be informed about the basics of the study and the potential benefits. Informed consent of the participants will be obtained after the nature of the procedures has been fully explained. Only those who provide the consent will be included in the study. They will also be reminded that they can withdraw their consent at any point to terminate their participation and that anonymity and confidentiality are ensured. Regarding the potential risks of the study, no risks are expected. Nevertheless, in case of adverse events (e.g. relevant clinical symptoms) individualized assistance will be offered. 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