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Various factors have been demonstrated to be associated with depressive symptoms, including negative life events (NLEs) and alexithymia. A retrospective study was conducted to investigate the relationship among negative life events, alexithymia, and depression symptoms in a psychosomatic outpatient sample in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 2747 outpatients (aged 18\u00a0\u2013\u00a065) were included in this investigation. The Life Events Scale (LES), Toronto alexithymia scale (TAS-26), and 9-item Patient Health Questionnaire (PHQ-9) were used to assess NLEs, alexithymia, and depressive symptoms, respectively. A stepwise regression analysis model was established to investigate the relationship among alexithymia, NLEs, and depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 67.0% of the patient sample had a PHQ-9 score of 10 or higher. The stepwise regression analysis model showed a well-fitted model, in which NLEs and alexithymia explain a total of 34.2% of the variance of depressive symptoms in these participants. NLEs (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.256,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and dimensions of alexithymia (difficult describing feelings (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.192,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and identifying feelings (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.308,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001)) were positively correlated with symptoms of depression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Previous studies have confirmed the correlation between NLEs and depression, alexithymia and depression, respectively. In our study, we used a stepwise regression model to explain the relationship among those variables simultaneously, and found that NLEs and alexithymia could function as predictors of depressive symptoms. Based on this discovery, alexithymia-focused treatment strategies could be alternative in depressive patients with alexithymia, but this remains to be verified in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12888-024-05902-0","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T11:03:07Z","timestamp":1718708587000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The association among negative life events, alexithymia, and depressive symptoms in a psychosomatic outpatient sample"],"prefix":"10.1186","volume":"24","author":[{"given":"Yinghan","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinya","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"issue":"3","key":"5902_CR1","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1002\/wps.20459","volume":"16","author":"CFR Reynolds","year":"2017","unstructured":"Reynolds CFR, Patel V. 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