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Follow-up measures of new-onset sarcopenia were obtained 4 years later. Then used logistic regression to evaluate the association between social isolation, loneliness and sarcopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In cross-sectional analysis, social isolation and loneliness are significantly associated with sarcopenia [OR\u2009=\u20091.88 (95% CI\u2009=\u20091.54\u20132.28)]. In longitudinal analysis, social isolation and loneliness are significantly associated with sarcopenia [OR\u2009=\u20091.09 (95% CI\u2009=\u20090.71\u20131.69)]. Social isolation and loneliness have a synergistic effect. Among them, individuals over 60 years old [OR\u2009=\u20092.01 (95% CI\u2009=\u20091.37\u20132.96)] and those without social support [OR\u2009=\u20092.64 (1.61\u20134.32),\n                      <jats:italic>P<\/jats:italic>\n                      -for interaction\u2009&lt;\u20090.001] are at higher risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Social isolation and loneliness were significantly associated with sarcopenia, and there was a synergistic effect between social isolation and loneliness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12888-024-05958-y","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T10:01:55Z","timestamp":1721296915000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The association of social isolation and loneliness with sarcopenia among the middle-aged and elderly in China"],"prefix":"10.1186","volume":"24","author":[{"given":"Lei","family":"Tu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minglan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longyang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"issue":"10366","key":"5958_CR1","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1016\/S0140-6736(22)02410-2","volume":"400","author":"L The","year":"2022","unstructured":"The L. 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