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All methods were carried out in accordance with applicable guidelines and regulations.The study protocol is also registered in the Clinical Trials Registry (Trial Registration) at ClinicalTrials.gov with the identifier ID: NCT06238414. Date of registration: 1st February 2024, final update is protocol version 3.0, 19th March 2024.Any protocol amendment that implies a protocol modification will be communicated to the investigators, institutes of research involved (VHIR and IDIBAPS), ethics committees, and the sponsor (La Marat\u00f3 de TV3 Foundation).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"We are currently recruiting participants for the trial.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Trial status"}},{"value":"The results will be written up in manuscripts. Additionally, the findings will be presented in platforms for discussion such as national and international conferences or seminars.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Dissemination policy"}},{"value":"J.A.R.Q was on the speakers\u2019 bureau and\/or has acted as a consultant for Biogen, Idorsia, Janssen-Cilag, Novartis, Takeda, Bial, Sincrolab, Neuraxpharm, Novartis, BMS, Medice, Rubi\u00f3, Uriach, Technofarma and Raffo in the last 3 years. He also received travel grants (air tickets + hotel) to attend psychiatric meetings held by Idorsia, Janssen-Cilag, Rubi\u00f3, Takeda, Bial and Medice. The Department of Psychiatry that he chairs has received unrestricted educational and research support from the following companies in the last 3 years: Exeltis, Idorsia, Janssen- Cilag, Neuraxpharm, Oryzon, Roche, Probitas, Psious, and Rubi\u00f3.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"666"}}