{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:17:03Z","timestamp":1772165823556,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"crossref","award":["1753\/2023"],"award-info":[{"award-number":["1753\/2023"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"crossref","award":["1753\/2023"],"award-info":[{"award-number":["1753\/2023"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"crossref","award":["1753\/2023"],"award-info":[{"award-number":["1753\/2023"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"crossref","award":["1753\/2023"],"award-info":[{"award-number":["1753\/2023"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"crossref","award":["1753\/2023"],"award-info":[{"award-number":["1753\/2023"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"crossref","award":["1753\/2023"],"award-info":[{"award-number":["1753\/2023"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"crossref","award":["1753\/2023"],"award-info":[{"award-number":["1753\/2023"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"crossref","award":["1753\/2023"],"award-info":[{"award-number":["1753\/2023"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Psychiatry"],"DOI":"10.1186\/s12888-025-07374-2","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T10:37:01Z","timestamp":1763980621000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety profile of vortioxetine as an add-on molecule in obsessive-compulsive disorder: a randomized double-blinded placebo-controlled superiority trial \u2013 a study protocol"],"prefix":"10.1186","volume":"25","author":[{"given":"Sucharita","family":"Mandal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaushik","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aparajita","family":"Guin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupal","family":"Sorkhel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pulama","family":"Mitra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bisweswar","family":"Ojha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamini","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukriti","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"7374_CR1","doi-asserted-by":"publisher","unstructured":"Reddy YCJ, Rao NP, Khanna S. An overview of Indian research in obsessive compulsive disorder. Indian Journal of Psychiatry. 2010;52(Suppl1):S200\u2013S209. https:\/\/doi.org\/10.4103\/0019-5545.69233","DOI":"10.4103\/0019-5545.69233"},{"key":"7374_CR2","unstructured":"Mind Voyage. The Prevalence of OCD in India. (n.d.). [Accessed 3 September 2025] https:\/\/mindvoyage.in\/the-prevalence-of-ocd-in-india\/"},{"key":"7374_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2024.02.031","author":"A Pozza","year":"2024","unstructured":"Pozza A, Ragucci F, Angelo NL, Pugi D, Cuomo A, Garcia-Hernandez MD, et al. Worldwide prevalence of obsessive-compulsive symptoms during the COVID-19 pandemic: a systematic review and meta-analysis. J Psychiatr Res. 2024. https:\/\/doi.org\/10.1016\/j.jpsychires.2024.02.031.","journal-title":"J Psychiatr Res"},{"key":"7374_CR4","unstructured":"Fineberg NA, et al. The size, burden and cost of disorders of the brain in the UK. J Psychopharmacol. 2017. [Accessed 3 September 2025] https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5310107\/"},{"issue":"8","key":"7374_CR5","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/S2215-0366(16)30069-4","volume":"3","author":"P Skapinakis","year":"2016","unstructured":"Skapinakis P, Caldwell DM, Hollingworth W, Bryden P, Fineberg NA, Salkovskis P, et al. Pharmacological and psychotherapeutic interventions for management of obsessive-compulsive disorder in adults: a systematic review and network meta-analysis. Lancet Psychiatry. 2016;3(8):730\u20139.","journal-title":"Lancet Psychiatry"},{"key":"7374_CR6","doi-asserted-by":"publisher","first-page":"1065812","DOI":"10.3389\/fpsyt.2023.1065812","volume":"14","author":"K Swierkosz-Lenart","year":"2023","unstructured":"Swierkosz-Lenart K, Dos Santos JF, Elowe J, Clair AH, Bally JF, Riquier F, Bloch J, Draganski B, Clerc MT, Pozuelo Moyano B, von Gunten A. Therapies for obsessive-compulsive disorder: current state of the Art and perspectives for approaching treatment-resistant patients. Front Psychiatry. 2023;14:1065812.","journal-title":"Front Psychiatry"},{"issue":"1","key":"7374_CR7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/acps.13568","volume":"148","author":"R Maiti","year":"2023","unstructured":"Maiti R, Mishra A, Srinivasan A, Mishra BR. Pharmacological augmentation of serotonin reuptake inhibitors in patients with obsessive\u2013compulsive disorder: a network meta-analysis. Acta Psychiatr Scand. 2023;148(1):19\u201331.","journal-title":"Acta Psychiatr Scand"},{"issue":"4","key":"7374_CR8","doi-asserted-by":"publisher","first-page":"676","DOI":"10.9758\/cpn.23.1075","volume":"21","author":"D Roh","year":"2023","unstructured":"Roh D, Jang KW, Kim CH. Clinical advances in treatment strategies for obsessive-compulsive disorder in adults. Clin Psychopharmacol Neurosci. 2023;21(4):676.","journal-title":"Clin Psychopharmacol Neurosci"},{"issue":"6","key":"7374_CR9","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1177\/15500594221076596","volume":"53","author":"S Hashempour","year":"2022","unstructured":"Hashempour S, Ansari S, Arbabi M, Etesam F, Sharafi SE, Khaje vand M, et al. Assessing the effectiveness of repetitive transcranial magnetic stimulation in the treatment of obsessive-compulsive disorder. Clin EEG Neurosci. 2022;53(6):491\u20138.","journal-title":"Clin EEG Neurosci"},{"issue":"8","key":"7374_CR10","doi-asserted-by":"publisher","first-page":"710","DOI":"10.2174\/1570159X16666180813155017","volume":"17","author":"A Del Casale","year":"2019","unstructured":"Del Casale A, Sorice S, Padovano A, Simmaco M, Ferracuti S, Lamis DA, et al. Psychopharmacological treatment of obsessive-compulsive disorder (OCD). Curr Neuropharmacol. 2019;17(8):710\u201336.","journal-title":"Curr Neuropharmacol"},{"key":"7374_CR11","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.psychres.2017.01.025","volume":"249","author":"CM Schwartzman","year":"2017","unstructured":"Schwartzman CM, Boisseau CL, Sibrava NJ, Mancebo MC, Eisen JL, Rasmussen SA. Symptom subtype and quality of life in obsessive-compulsive disorder. Psychiatry Res. 2017;249:307\u201310.","journal-title":"Psychiatry Res"},{"key":"7374_CR12","first-page":"331","volume":"10","author":"C Pittenger","year":"2021","unstructured":"Pittenger C. Pharmacotherapeutic strategies and new targets in OCD. Neurobiol Treat OCD: Accel Prog. 2021;10:331\u201384.","journal-title":"Neurobiol Treat OCD: Accel Prog."},{"key":"7374_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2022.152352","volume":"120","author":"PJ Van Roessel","year":"2023","unstructured":"Van Roessel PJ, Grassi G, Aboujaoude EN, Mench\u00f3n JM, Van Ameringen M, Rodr\u00edguez CI. Treatment-resistant OCD: pharmacotherapies in adults. Compr Psychiatry. 2023;120:152352.","journal-title":"Compr Psychiatry"},{"key":"7374_CR14","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.pharmthera.2014.07.001","volume":"145","author":"C Sanchez","year":"2015","unstructured":"Sanchez C, Asin KE, Artigas F. Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data. Pharmacol Ther. 2015;145:43\u201357.","journal-title":"Pharmacol Ther"},{"issue":"5","key":"7374_CR15","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1080\/14740338.2022.2019705","volume":"21","author":"J De Diego-Adeli\u00f1o","year":"2022","unstructured":"De Diego-Adeli\u00f1o J, Crespo JM, Mora F, Neyra A, Iborra P, Guti\u00e9rrez-Rojas L, et al. Vortioxetine in major depressive disorder: from mechanisms of action to clinical studies. An updated review. Expert Opin Drug Saf. 2022;21(5):673\u201390.","journal-title":"Expert Opin Drug Saf"},{"issue":"1","key":"7374_CR16","first-page":"36","volume":"40","author":"A D\u2019agostino","year":"2015","unstructured":"D\u2019agostino A, English CD, Rey JA. Vortioxetine (brintellix): a new serotonergic antidepressant. Pharm Ther. 2015;40(1):36.","journal-title":"Pharm Ther"},{"issue":"1","key":"7374_CR17","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1080\/13651501.2016.1225098","volume":"21","author":"A Hegde","year":"2017","unstructured":"Hegde A, Kalyani BG, Arumugham SS, Narayanaswamy JC, Math SB, Reddy YCJ. Aripiprazole augmentation in highly treatment-resistant obsessive\u2013compulsive disorder \u2013 experience from a specialty clinic in India. Int J Psychiatry Clin Pract. 2017;21(1):67\u20139.","journal-title":"Int J Psychiatry Clin Pract"},{"issue":"3","key":"7374_CR18","doi-asserted-by":"publisher","first-page":"356","DOI":"10.4103\/kleuhsj.kleuhsj_29_21","volume":"14","author":"J Ahmad","year":"2021","unstructured":"Ahmad J, Nischal A, Nischal A, Gupta B, Agarwal M, Tripathi A. Ondansetron in combination with fluoxetine for obsessive\u2013compulsive disorder: a randomized, double-blind, placebo-controlled study from North India. Indian Journal of Health Sciences and Biomedical Research (KLEU). 2021;14(3):356\u201364.","journal-title":"Indian Journal of Health Sciences and Biomedical Research (KLEU)"},{"issue":"Suppl 1","key":"7374_CR19","doi-asserted-by":"publisher","first-page":"S74","DOI":"10.4103\/0019-5545.196976","volume":"59","author":"YJ Reddy","year":"2017","unstructured":"Reddy YJ, Sundar AS, Narayanaswamy JC, Math SB. Clinical practice guidelines for obsessive-compulsive disorder. Indian J Psychiatry. 2017;59(Suppl 1):S74\u201390.","journal-title":"Indian J Psychiatry"}],"container-title":["BMC Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12888-025-07374-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12888-025-07374-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12888-025-07374-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T14:00:47Z","timestamp":1764684047000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/10.1186\/s12888-025-07374-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7374"],"URL":"https:\/\/doi.org\/10.1186\/s12888-025-07374-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6819606\/v1","asserted-by":"object"}]},"ISSN":["1471-244X"],"issn-type":[{"value":"1471-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,24]]},"assertion":[{"value":"4 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the original publication, there was a typo in the word participants. The article has been updated to rectify the error.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The clinical trial commenced only after obtaining prior written approval from the Institutional Ethics Committee (IEC) of AIIMS Kalyani and successful registration with the Clinical Trials Registry - India (CTRI). As this is an academic clinical trial involving a drug already approved for a different indication (vortioxetine for major depressive disorder), permission from the Central Licensing Authority (CLA) under the DCGI was not required. The study adheres strictly to the ethical principles outlined in the Declaration of Helsinki and complies with the Indian Council of Medical Research (ICMR) guidelines for biomedical research involving human participants. Written informed consent is obtained from all participants in their native language, ensuring they fully understand the study procedures, potential risks, benefits, and their right to withdraw at any stage without any consequences. No participant is subjected to financial burden; all costs associated with the study are borne by the institution. The confidentiality of all participant data is maintained. Identifiable information is de-identified prior to analysis, and data is stored securely with restricted access limited to authorized study investigators. Participants are also provided with the contact details of both the principal investigator and the ethics committee to report any concerns or adverse events.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable, as the protocol does not include any individual person\u2019s data in any form, including images, videos, or clinical details.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1116"}}