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TB-HIV co-infected people are facing multifaceted problems like high lost to follow up rates, poor treatment adherence, high TB recurrence rate, and high mortality risk. Our objective was to a<jats:italic>ssess the outcomes<\/jats:italic> of TB <jats:italic>treatment and associated factors among TB-HIV co-infected patients in Harar town, Eastern part of Ethiopia<\/jats:italic>, 2018.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A retrospective study was conducted among systematically selected 349\u2009TB\/HIV co-infected patients who registered from 2012 to 2017 in two public hospitals in Harar town. The data were collected through document review by using a pre-tested structured data extraction checklist. The data were analyzed using SPSS Version 21. Bivariate and multivariate logistic regression were determined at 95% confidence intervals.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Among the 349\u2009TB\/HIV co-infected patients included in the study, 30.1% were cured, 56.7% had completed their treatment, 7.7% died, 1.7% were lost to follow up, and 3.7% were treatment failure. Overall, 86.8% of the TB-HIV co-infected patients had successful TB treatment outcomes. The patients who were on re-treatment category (AOR\u2009=\u20092.91, 95% CI: 1.17\u20137.28), who had a history of opportunistic infection (AOR\u2009=\u20093.68, 95% CI: 1.62\u20138.33), and who did not take co-trimoxazole prophylaxis (AOR\u2009=\u20093.54, 95% CI: 1.59\u20137.89) had 2.91, 3.68, and 3.54 times higher odds of having unsuccessful TB treatment outcome than their counterparties, respectively. The chance of unsuccessful TB treatment outcome was 4.46 (95% CI: 1.24\u201316.02), 5.94 (95% CI: 1.87\u201318.85), and 3.01 (95% CI: 1.15\u20137.91) times higher among TB\/HIV patients in stage 2, 3 and 4 than those in stage 1, respectively.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The overall rate of the success of the TB treatment among TB-HIV co-infected patients in this study was higher compared with many previous studies. TB\/HIV patients with a history of previous TB treatment, smear-positive pulmonary TB, late HIV stage, history of opportunistic infection and not being on co-trimoxazole prophylaxis therapy were at a high risk of getting poor treatment outcomes.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12889-019-7980-x","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T12:04:28Z","timestamp":1575979468000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Treatment Outcome of Tuberculosis and Associated Factors among TB-HIV Co-Infected Patients at Public Hospitals of Harar Town, Eastern Ethiopia. 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A legal permission letter was taken from Harar Health Science College to the selected public hospitals and permission was obtained from the administration of the hospitals. Furthermore, before reviewing medical records of the TB\/HIV co-infected patients, permission was obtained from the TB treatment unit heads of the hospital. Patient records\/information was anonymized and de-identified prior to analysis. Since the data were collected through a review of medical records and confidentiality is maintained, there is no harm to the patients and their relatives.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1658"}}