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Numerous prevention programmes have a general objective, but in adolescence individual vulnerabilities towards addictions differ significantly with personality traits. Prevention targeting personality traits enables work on risk factors for addictive behaviours, and has shown genuine efficacy.<\/jats:p>\n                <jats:p>Among existing programmes, PREVENTURE has shown an effect on the reduction in alcohol consumption by targeting four personality traits: impulsivity, sensation-seeking, negative thoughts and anxiety. This programme has been tested on samples recruited in adolescent populations in school environments, identifying adolescents at risk, but it has not been tested on a more targeted recruitment of adolescents seen in consultation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The main hypothesis of this study is that the targeted prevention programme PREVENTURE will have an impact on the prevalence of binge-drinking episodes. The secondary hypotheses explore other factors such as associated substance use, anxiety and depression, as well as the acceptability of the programme. This article presents the study protocol of \u201cPREVADO\u201d study.<\/jats:p>\n                <jats:p>We intend to assess the impact of the targeted intervention programme PREVENTURE on the prevalence of binge-drinking episodes among adolescents aged 14 to 17\u2009years consulting in one of the participating centres or referred by a school doctor. The study will be prospective, randomised, controlled and open-label, and will comprise an intervention group and a control group.<\/jats:p>\n                <jats:p>The adolescents will then be followed and assessed 1, 3, 6 and 12\u2009months after the intervention.<\/jats:p>\n                <jats:p>The study needs to include 700 subjects in order to reach 340 adolescents randomised, 170 in each group. It will concern 33 centres.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>This project could favour the targeting of addictive behaviours among vulnerable adolescents, and its application on a larger scale could be envisaged.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>The Trial registration number is <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04599270\">NCT04599270<\/jats:ext-link>, and it was registered on the <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> public website.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12889-021-10795-9","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T10:04:14Z","timestamp":1619172254000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The efficacy of a targeted PREVENTION programme for addictive behaviour (PREVENTURE) among vulnerable ADOlescents in France - study procotol"],"prefix":"10.1186","volume":"21","author":[{"given":"morgane","family":"guillou-landreat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elkhan","family":"Tahmazov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schreck","family":"Benoit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Grall-bronnec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Conrod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Livet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean -Yves","family":"Le Reste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,23]]},"reference":[{"key":"10795_CR1","doi-asserted-by":"publisher","first-page":"172906","DOI":"10.1016\/j.pbb.2020.172906","volume":"192","author":"B Lees","year":"2020","unstructured":"Lees B, Meredith LR, Kirkland AE, Bryant BE, Squeglia LM. 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It was accepted on the february 15th 2021 (29BRC20.0114). All the data will be anonymised, and all participants and participating parents s will be asked to provide written informed consent.In the event of a substantial change to the protocol made by the investigator, it will be approved by the sponsor. The sponsor must obtain a favorable opinion from the CPP prior to its implementation. 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