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The Bacillus Calmette-Gu\u00e9rin (BCG) vaccine has non-specific effects. Studies suggest that maternal BCG-vaccination may affect the health of the child.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The present study is nested within a randomised trial in rural Guinea-Bissau: Pregnancies were registered at two-monthly village visits, where information on BCG scar status and other background factors were obtained. Children were enrolled in the trial and weighed at home within 72\u2009h after birth. In this prospective observational study, we assessed factors associated with adverse pregnancy outcomes and birthweight in binomial and linear regression models.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among 1320 women who had their BCG scar status assessed, 848 (64%) had a scar, 472 (36%) had no scar. The risk of adverse pregnancy outcomes (miscarriages, stillbirths, early neonatal deaths) tended to be higher among BCG scar-negative women (13%) than among women with a BCG scar (10%), adjusted prevalence ratio\u2009=\u20091.29 (0.99\u20131.68). Birthweight was assessed for 628 (50%) of the 1232 live born children. The mean birthweight was 2.89\u2009kg (SD 0.43) and the proportion of LBW children was 17% (104\/628). Sex, twinning, region of birth, maternal age, maternal mid-upper arm circumference (MUAC), antenatal consultations, parity and possession of a mobile phone were associated with birthweight, while maternal BCG scar status was not.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study provides the first birthweight data for home-born children in rural Guinea-Bissau, with a mean birthweight of 2.89\u2009kg (SD 0.43) and a LBW prevalence of 17%. We found a tendency for higher risk of adverse pregnancy outcomes among BCG scar-negative women. Birthweight was similar in children of mothers with and without BCG scar.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12889-021-11215-8","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T13:04:07Z","timestamp":1623935047000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Factors associated with birthweight and adverse pregnancy outcomes among children in rural Guinea-Bissau - a prospective observational study"],"prefix":"10.1186","volume":"21","author":[{"given":"Alexander Dahl","family":"Stjernholm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne Marie","family":"Thysen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igualdino Da Silva","family":"Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane B\u00e6rent","family":"Fisker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"11215_CR1","volume-title":"The United Nations Childrens' Fund: Low Birthweight: Country, regional and global estimates","author":"World Health Organization","year":"2004","unstructured":"World Health Organization. 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The BCGR trial, with the collection of the data used in the present analysis, is approved by the Guinean Ethical Committee (Reference number: 0016\/CNES\/INASA\/2015) and the Danish Central Ethics committee has given its consultative approval. No separate approval was sought for the present study. The trial is registered at clinicaltrials.gov (ID: NCT02504203). Written informed consent was obtained from all pregnant women included in this study. The methods in the study were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1164"}}