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This study aimed to compare the epidemiological characteristics of dengue fever in Guangdong and Yunnan during 2004\u20132018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Descriptive analyses were used to explore the temporal, spatial, and demographic distribution of dengue fever.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 73,761 dengue cases reported in mainland China during 2004\u20132018, 93.7% indigenous and 65.9% imported cases occurred in Guangdong and Yunnan, respectively. A total of 55,970 and 5938 indigenous cases occurred in 108 Guangdong and 8 Yunnan counties, respectively during 2004\u20132018. Whereas 1146 and 3050 imported cases occurred in 84 Guangdong and 72 Yunnan counties, respectively during 2004\u20132018. Guangdong had a much higher average yearly indigenous incidence rate (3.65 (1\/100000) vs 0.86 (1\/100000)), but a much lower average yearly imported incidence rate (0.07 (1\/100000) vs 0.44(1\/100000)) compared with Yunnan in 2004\u20132018. Furthermore, dengue fever occurred more widely in space and more frequently in time in Guangdong. Guangdong and Yunnan had similar seasonal characteristics for dengue fever, but Guangdong had a longer peak period. Most dengue cases were clustered in the south-western border of Yunnan and the Pearl River Delta region in Guangdong. Most of the imported cases (93.9%) in Guangdong and Yunnan were from 9 Southeast Asian countries. Thailand, Cambodia, and Malaysia imported mainly into Guangdong while Myanmar and Laos imported into Yunnan. There was a strong male predominance among imported cases and an almost equal gender distribution among indigenous cases. Most dengue cases occurred in individuals aged 21\u201350\u2009years, accounting for 57.3% (Guangdong) vs. 62.8% (Yunnan) of indigenous and 83.2% (Guangdong) vs. 62.6% (Yunnan) of imported cases. The associated major occupations (house worker or unemployed, retiree, and businessman, for indigenous cases; and businessman, for imported cases), were similar. However, farmers accounted for a larger proportion of dengue cases in Yunnan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Identifying the different epidemiological characteristics of dengue fever in Guangdong and Yunnan can be helpful to formulate targeted, strategic plans, and implement effective public health prevention measures in China.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12889-021-11323-5","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T08:06:04Z","timestamp":1626163564000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Comparative analyses on epidemiological characteristics of dengue fever in Guangdong and Yunnan, China, 2004\u20132018"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6949-6820","authenticated-orcid":false,"given":"Yujuan","family":"Yue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"issue":"7446","key":"11323_CR1","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nature12060","volume":"496","author":"S Bhatt","year":"2013","unstructured":"Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. 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No human or animal samples were included in the research presented in this article, therefore ethical approval was not necessary for this research according to Measures for ethical review of biomedical research involving human beings (No. 11 of National health commission of the People\u2019s Republic of China.\n                      \n                      ). We obtained the permissions from Chinese Center for Disease Control and Prevention, Chinese Meteorological Administration, National Bureau of Statistics of China, Bureau of Statistics of Yunnan and Bureau of Statistics of Guangdong to access all the data in this research. As a member of Chinese Center for Disease Control and Prevention, data analysis of infectious disease was one part of my job, and I had the license to access dengue cases. Other data in this research were nearly public, and I just needed to apply an account to access them. Before submission, the manuscript also passed the examination of our institute.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1389"}}