{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:19:24Z","timestamp":1791965964989,"version":"4.3.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["This work was sponsored by the Centers for Disease Control and Prevention. Los Alamos National Laboratory, an affirmative action\/equal opportunity employer, is operated by Triad National Security, LLC, for the National Nuclear Security Administration of the U.S. Department of Energy under contract # 19FED1916814CKC."],"award-info":[{"award-number":["This work was sponsored by the Centers for Disease Control and Prevention. Los Alamos National Laboratory, an affirmative action\/equal opportunity employer, is operated by Triad National Security, LLC, for the National Nuclear Security Administration of the U.S. Department of Energy under contract # 19FED1916814CKC."]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["This work was sponsored by the Centers for Disease Control and Prevention. Los Alamos National Laboratory, an affirmative action\/equal opportunity employer, is operated by Triad National Security, LLC, for the National Nuclear Security Administration of the U.S. Department of Energy under contract # 19FED1916814CKC."],"award-info":[{"award-number":["This work was sponsored by the Centers for Disease Control and Prevention. Los Alamos National Laboratory, an affirmative action\/equal opportunity employer, is operated by Triad National Security, LLC, for the National Nuclear Security Administration of the U.S. Department of Energy under contract # 19FED1916814CKC."]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Public Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Nonpharmaceutical interventions (NPIs) may be considered as part of national pandemic preparedness as a first line defense against influenza pandemics. Preemptive school closures (PSCs) are an NPI reserved for severe pandemics and are highly effective in slowing influenza spread but have unintended consequences.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We used results of simulated PSC impacts for a 1957-like pandemic (i.e., an influenza pandemic with a high case fatality rate) to estimate population health impacts and quantify PSC costs at the national level using three geographical scales, four closure durations, and three dismissal decision criteria (i.e., the number of cases detected to trigger closures). At the Chicago regional level, we also used results from simulated 1957-like, 1968-like, and 2009-like pandemics. Our net estimated economic impacts resulted from educational productivity costs plus loss of income associated with providing childcare during closures after netting out productivity gains from averted influenza illness based on the number of cases and deaths for each mitigation strategy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>For the 1957-like, national-level model, estimated net PSC costs and averted cases ranged from $7.5 billion (2016 USD) averting 14.5 million cases for two-week, community-level closures to $97 billion averting 47 million cases for 12-week, county-level closures. We found that 2-week school-by-school PSCs had the lowest cost per discounted life-year gained compared to county-wide or school district\u2013wide closures for both the national and Chicago regional-level analyses of all pandemics. The feasibility of spatiotemporally precise triggering is questionable for most locales. Theoretically, this would be an attractive early option to allow more time to assess transmissibility and severity of a novel influenza virus. However, we also found that county-wide PSCs of longer durations (8 to 12\u00a0weeks) could avert the most cases (31\u201347 million) and deaths (105,000\u2013156,000); however, the net cost would be considerably greater ($88-$103 billion net of averted illness costs) for the national-level, 1957-like analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We found that the net costs per death averted ($180,000-$4.2 million) for the national-level, 1957-like scenarios were generally less than the range of values recommended for regulatory impact analyses ($4.6 to 15.0 million). This suggests that the economic benefits of national-level PSC strategies could exceed the costs of these interventions during future pandemics with highly transmissible strains with high case fatality rates. In contrast, the PSC outcomes for regional models of the 1968-like and 2009-like pandemics were less likely to be cost effective; more targeted and shorter duration closures would be recommended for these pandemics.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12889-023-17469-8","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T07:02:58Z","timestamp":1705474978000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cost effectiveness of preemptive school closures to mitigate pandemic influenza outbreaks of differing severity in the United States"],"prefix":"10.1186","volume":"24","author":[{"given":"Lori R.","family":"Dauelsberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Maskery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heesoo","family":"Joo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Germann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Y.","family":"Del Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amra","family":"Uzicanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"17469_CR1","doi-asserted-by":"crossref","unstructured":"Webster RG, Monto AS, Braciale TJ, Lamb RA. Textbook of influenza. 2 edition ed: Wiley; 2013 September 23, 2013.","DOI":"10.1002\/9781118636817"},{"key":"17469_CR2","unstructured":"Department of Health and Human Services. Pandemic influenza plan, 2017 Update. https:\/\/www.cdc.gov\/flu\/pandemic-resources\/pdf\/pan-flu-report-2017v2.pdf. 2017."},{"issue":"RR-1","key":"17469_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15585\/mmwr.rr6601a1","volume":"66","author":"N Qualls","year":"2017","unstructured":"Qualls N, Levitt A, Kanade N, et al. Community mitigation guidelines to prevent pandemic influenza \u2014 United States, 2017. MMWR Recomm Rep. 2017;66(RR-1):1\u201334.","journal-title":"MMWR Recomm Rep"},{"key":"17469_CR4","unstructured":"Community Preventive Services Task Force (CPSTF). Emergence preparedness: school dismissals to reduce transmission of pandemic influenza. The Community Guide, 2012. 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NBER Working Paper Series (28934). http:\/\/www.nber.org\/papers\/w28934. 2021.","DOI":"10.3386\/w28934"}],"container-title":["BMC Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12889-023-17469-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12889-023-17469-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12889-023-17469-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T07:03:14Z","timestamp":1705474994000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpublichealth.biomedcentral.com\/articles\/10.1186\/s12889-023-17469-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,17]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["17469"],"URL":"https:\/\/doi.org\/10.1186\/s12889-023-17469-8","relation":{},"ISSN":["1471-2458"],"issn-type":[{"value":"1471-2458","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,17]]},"assertion":[{"value":"14 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All methods were carried out in accordance with relevant guidelines and regulations. Because this research did not involve human subjects, it was not subject to IRB review requirements.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"200"}}