{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:07:42Z","timestamp":1769630862394,"version":"3.49.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Public Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>The goal of epilepsy treatment is not only to control convulsive seizures but also to improve the quality of life of patients. This study aimed to investigate personality changes and the risk factors for their development in adult epilepsy patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A case-control study in a Class III, Class A hospital. The study comprised 206 adult epilepsy patients admitted to the Neurology Department at the First Hospital of Jilin University between October 2019 and December 2021, while the control group consisted of 154 community volunteers matched with the epilepsy group based on age, sex, and education. No additional treatment interventions were determined to be relevant in the context of this study.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There is a significantly higher incidence of personality changes in epilepsy than in the general population, and patients with epilepsy were more likely to become psychoticism, neuroticism, and lie. Epilepsy patient\u2019s employment rate and average quality of life score were significantly lower than that of the general population and had strong family intimacy but poor adaptability in this study. There are many factors affecting personality change: sleep disorders, economic status, quality of life, use of anti-seizure drugs, family cohesion and adaptability. The independent risk factors were quality of life and family cohesion.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12889-024-18861-8","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T06:02:39Z","timestamp":1716444159000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Family cohesion and quality of life significantly affecting personality changes in adult epilepsy patients: a case-control study"],"prefix":"10.1186","volume":"24","author":[{"given":"Jiaai","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salamaitiguli","family":"Mijiti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinyin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingqi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"issue":"3","key":"18861_CR1","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S0006-3223(03)00469-4","volume":"54","author":"AM Kanner","year":"2003","unstructured":"Kanner AM. Depression in Epilepsy: prevalence, clinical semiology, pathogenic mechanisms, and treatment. Biol Psychiatry. 2003;54(3):388\u201398.","journal-title":"Biol Psychiatry"},{"issue":"124","key":"18861_CR2","first-page":"345","volume":"21","author":"E Jarzebska","year":"2006","unstructured":"Jarzebska E. The personality change in epilepsy patients. Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego. 2006;21(124):345\u20137.","journal-title":"Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego"},{"issue":"4","key":"18861_CR3","first-page":"224","volume":"45","author":"LY Mao","year":"2012","unstructured":"Mao LY, Ding J, Peng WF, Zhang YH, Ma Y, Fan W, Wang X. Interictal personality change and its related factors in epilepsy patients. Chin J Neurol. 2012;45(4):224\u20138.","journal-title":"Chin J Neurol"},{"key":"18861_CR4","unstructured":"Boldyrev AI. Pathomorphosis of personality changes in patients with epilepsy. Zhurnal Nevropatologii i psikhiatrii imeni SS Korsakova (Moscow Russia: 1952). 1989;89(6):50\u20133."},{"issue":"9","key":"18861_CR5","first-page":"1999","volume":"51","author":"X Cong","year":"2022","unstructured":"Cong X, Li Y, Bian R. Relationship between Neuroticism and gastrointestinal symptoms in irritable bowel syndrome: the mediating role of Sleep. Iran J Public Health. 2022;51(9):1999\u20132006.","journal-title":"Iran J Public Health"},{"issue":"2","key":"18861_CR6","first-page":"106","volume":"2","author":"XQ Liu","year":"2003","unstructured":"Liu XQ, Ren XL, Zhou GL, Chen PY. Reliabity and validity for quality of life in epilepsy \u2013\u200931 scale in adults with epilepsy. Chin J Neuromedicine. 2003;2(2):106\u20139.","journal-title":"Chin J Neuromedicine"},{"issue":"1","key":"18861_CR7","first-page":"178","volume":"28","author":"L Li","year":"2020","unstructured":"Li L, Ye BJ, Ni LY, Yang Q. Family Cohesion on Prosocial Behavior in College students: Moderated Mediating Effect. Chin J Clin Psychol. 2020;28(1):178\u201380.","journal-title":"Chin J Clin Psychol"},{"key":"18861_CR8","unstructured":"Fei LP, Shen QJ, Zheng YP, Zhao JP, Jiang SA, Wang LW, Wang XD. Preliminary evaluation of Chinese version of FACES II and FES: comparison of normalfamilies and families of schizophrenic patients. Chin Mental Health J 1991(05):198\u2013202."},{"issue":"3","key":"18861_CR9","first-page":"407","volume":"29","author":"MZ Chen","year":"2021","unstructured":"Chen MZ, Sun YY. Correlation of family cohesion,family adaptability and network dependence:the mediation effect of loneliness. China J Health Psychol. 2021;29(3):407\u201312.","journal-title":"China J Health Psychol"},{"issue":"4","key":"18861_CR10","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/j.0013-9580.2005.66104.x","volume":"46","author":"RS Fisher","year":"2005","unstructured":"Fisher RS, van Emde Boas W, Blume W, Elger C, Genton P, Lee P, Engel J Jr. Epileptic seizures and epilepsy: definitions proposed by the International League against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia. 2005;46(4):470\u20132.","journal-title":"Epilepsia"},{"issue":"5","key":"18861_CR11","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/NMD.0b013e31828e0e3d","volume":"201","author":"E Yazici","year":"2013","unstructured":"Yazici E, Yazici AB, Aydin N, Orhan A, Kirpinar I, Acemoglu H. Temperament and character traits in patients with epilepsy: epileptic personality. J Nerv Ment Dis. 2013;201(5):365\u201370.","journal-title":"J Nerv Ment Dis"},{"issue":"1","key":"18861_CR12","first-page":"34","volume":"6","author":"DT Zhu","year":"2002","unstructured":"Zhu DT, Jin LJ, Xie GJ. Quality of life and personality in patients with epilepsy. Chin J Clin REHABILITATION. 2002;6(1):34\u20136.","journal-title":"Chin J Clin REHABILITATION"},{"issue":"1","key":"18861_CR13","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.yebeh.2008.08.014","volume":"14","author":"GA Shehata","year":"2009","unstructured":"Shehata GA, Bateh Ael A. Cognitive function, mood, behavioral aspects, and personality traits of adult males with idiopathic epilepsy. Epilepsy Behavior: E&B. 2009;14(1):121\u20134.","journal-title":"Epilepsy Behavior: E&B"},{"issue":"11","key":"18861_CR14","first-page":"1239","volume":"21","author":"XM Wei","year":"2009","unstructured":"Wei XM. Study of personality characteristics and related factors of adults with epilepsy. Med J Chin PEOPLE\u2019S HEALTH. 2009;21(11):1239\u201340.","journal-title":"Med J Chin PEOPLE\u2019S HEALTH"},{"key":"18861_CR15","doi-asserted-by":"crossref","unstructured":"Smeets VM, van Lierop BA, Vanhoutvin JP, Aldenkamp AP, Nijhuis FJ. Epilepsy and employment: literature review. Epilepsy Behavior: E&B. 2007;10(3):354\u201362.","DOI":"10.1016\/j.yebeh.2007.02.006"},{"key":"18861_CR16","doi-asserted-by":"crossref","unstructured":"Mula M, Trimble MR. The importance of being seizure free: topiramate and psychopathology in epilepsy. Epilepsy & behavior: E&B 2003, 4(4):430\u2013434.","DOI":"10.1016\/S1525-5050(03)00145-8"},{"issue":"3","key":"18861_CR17","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1136\/jme.10.3.124","volume":"10","author":"KC Calman","year":"1984","unstructured":"Calman KC. Quality of life in cancer patients\u2013an hypothesis. J Med Ethics. 1984;10(3):124\u20137.","journal-title":"J Med Ethics"}],"container-title":["BMC Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12889-024-18861-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12889-024-18861-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12889-024-18861-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T06:03:14Z","timestamp":1716444194000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpublichealth.biomedcentral.com\/articles\/10.1186\/s12889-024-18861-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,23]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["18861"],"URL":"https:\/\/doi.org\/10.1186\/s12889-024-18861-8","relation":{},"ISSN":["1471-2458"],"issn-type":[{"value":"1471-2458","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,23]]},"assertion":[{"value":"22 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study has been approved by Ethics Committee of the First Hospital of Jilin University. (Approval number: 24K007-001, Approval date: 2024-01-16, Project name: \u201cClinical, EEG characteristics and Related Biomarkers of epilepsy and its comorbidity\u201d). This study was a retrospective study rather than a clinical trial.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"We confirm that we have read the Journal\u2019s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Subjects agreed to be included in the study, actively provided relevant clinical information and follow-up needs, and signed relevant informed consent.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent"}},{"value":"We declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"1381"}}