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This study was conducted to investigate the impact of the economic crisis on the burden of HBV and HCV disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Global Burden of Diseases 2019 data were used to analyse the rates of epidemiological metrics of HBV and HCV acute and chronic infections in SWE and WE. Time series modelling was performed to quantify the impact of healthcare expenditure on the time trend of HBV and HCV disease burden in 2000\u20132019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Declining trends in incidence and prevalence rates of acute HBV (aHBV) and chronic HBV were observed in SWE and WE, with the pace of decline being slower in the post-austerity period (2010\u20132019) and mortality due to HBV stabilised in SWE. Acute HCV (aHCV) metrics and chronic HCV incidence and mortality showed a stable trend in SWE and WE, whereas the prevalence of chronic HCV showed an oscillating trend, decreasing in WE in 2010\u20132019 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Liver cancer due to both hepatitis infections showed a stagnant burden over time. An inverse association was observed between health expenditure and metrics of both acute and chronic HBV and HCV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Epidemiological metrics for HBV and HCV showed a slower pace of decline in the post-austerity period with better improvement for HBV, a stabilisation of mortality and a stagnant burden for liver cancer due to both hepatitis infections. The economic crisis of 2008 had a negative impact on the burden of hepatitis B and C. Elimination of HBV and HCV by 2030 will be a major challenge in the SWE countries.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12889-024-18912-0","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T04:02:09Z","timestamp":1718856129000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of the 2008 economic crisis on the burden of hepatitis B and C diseases in Southern European countries"],"prefix":"10.1186","volume":"24","author":[{"given":"Claudia","family":"Palladino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca","family":"Ramis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ifeanyi Jude","family":"Ezeonwumelu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Biondi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Carreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvano","family":"Gallus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Golinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Gorini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoaib","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zubair","family":"Kabir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Koyanagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey V.","family":"Lazarus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexios-Fotios A.","family":"Mentis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuomo J.","family":"Meretoja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali H.","family":"Mokdad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Monasta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesk","family":"Mulita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten J.","family":"Postma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Tabar\u00e9s-Seisdedos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arulmani","family":"Thiyagarajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuno","family":"Taveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Briz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"GBD 2019 Southern Europe Hepatitis B & C Collaborators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"18912_CR1","unstructured":"Sixty-Seventh World Health Assembly. 67th World Health Assembly Resolution on Hepatitis (WHA67.6). 2014;67.6(May):1\u20136. 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(national funding), under a contract-programme as defined by DL No. 57\/2016 and Law No. 57\/2017 (DL57\/2016\/CP1376\/CT0004),(). I Ezenowumelu reports financial support for presenting at the 2023 Conference on Retroviruses and Opportunistic Infections (CROI 2023) by the CROI New Investigator Scholarship. V Lazarus reports grants or contracts from AbbVie, Gilead Sciences, MSD, Roche Diagnostics; royalties or licenses from Novavax; payment or honoraria for lectures from AbbVie, Gilead Sciences, Intercept, Janssen, Novo Nordisk; participation on a Data Safety Monitoring Board or Advisory Board with Same-visit hepatitis C testing and treatment to accelerate cure among people who inject drugs (The QuickStart Study): a cluster randomised control trial \u2013 Australia; leadership or fiduciary roles in board, society, committee or advocacy groups, paid or unpaid with EASL Public Health and Policy Committee as a member, HIV Outcomes as a co-chair, and SHARE Global Health Foundation; all outside the submitted work. A-F A Mentis reports grants or contracts from \u2018MilkSafe: A novel pipeline to enrich formula milk using omics technologies\u2019, a research co-financed by the European Regional Development Fund of the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH\u2014CREATE\u2014INNOVATE (project code: T2EDK-02222), as well as from ELIDEK (Hellenic Foundation for Research and Innovation, MIMS-860); payment for expert testimony from saving as an external peer-reviewer for Fondazione Cariplo, Italy; leadership or fiduciary roles in board, society, committee or advocacy groups, paid or unpaid as an editorial board member for Systematic Reviews and Annals of Epidemiology, and as an associate editor for Translational Psychiatry; and other financial or non-financial interests having served as a scientific officer for \u201cBGI Group\u201d over the last year, all outside the submitted work. L Monasta reports support for the present manuscript from the Italian Ministry of Health (Ricerca Corrente 34\/2017), payments made to the Institute for Maternal and Child Health IRCCS Burlo Garofolo. M J Postma reports stock or stock options in PAG BV (Groningen, Netherlands) and HealthEcore (Zeist, Netherlands). R Tabares-Sesdedos reports grants or contracts from the Spanish Ministry of Innovation, Institute of Health Carlos III (PID2021-129099OB-I00) and Generalitat Valenciana (CIPROM\/2022\/58), payments made to the University of Valencia, all outside the submitted work. V Briz reports financial support by Instituto de Salud Carlos III (PI18CIII\/00020). All other authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1642"}}