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However, there is a dearth of information on the long-term impact of HIV infection on the health and wellbeing of PLWH in sub-Saharan Africa. This research aimed to fill this gap by reporting on physical, functional and social outcomes among PLWH treated at a referral center in Abidjan, Ivory Coast, and comparing them with those of a control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Body composition, functional capacity, sarcopenia, limitations in daily activities and social participation were assessed among 300 PLWH (aged\u2009\u2265\u200930\u00a0years) and 200 uninfected adults of similar age and sex. The associations between these outcomes and participants\u2019 socioeconomic characteristics, HIV history and physical activity level were assessed using generalized additive models adjusted for age and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age was 51\u00a0years, and the median antiretroviral therapy duration was 15\u00a0years. Compared to controls, PLWH reported higher levels of physical activity (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). They had a lower muscle index (adjusted<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and grip strength (adjusted<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) but achieved similar performance on the 6-min walk test (6MWT,<jats:italic>p<\/jats:italic>\u2009=\u20090.2). Among PLWH, physical activity level was positively associated with better performance in the 6MWT (<jats:italic>p<\/jats:italic>\u2009=\u20090.006) and greater hand grip strength (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). The difference in physical performance according to the level of physical activity appeared mainly after the age of 60. PLWH reported similar rates of activity limitations (<jats:italic>p<\/jats:italic>\u2009=\u20090.8), lower depression levels and greater scores for social functioning (<jats:italic>p<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, PLWH achieved high levels of physical activity, which may explain why they maintained good physical performance and social functioning despite having a higher risk of sarcopenia. These results have important implications for resource-limited health systems and show avenues for chronic care models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p>This study was registered on the ClinicalTrials.gov website (NCT05199831, first registration the 20\/01\/2022).<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12889-024-19020-9","type":"journal-article","created":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T07:02:12Z","timestamp":1717830132000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The association between HIV infection, disability and lifestyle activity among middle-aged and older adults: an analytical cross-sectional study in Ivory Coast (the VIRAGE study)"],"prefix":"10.1186","volume":"24","author":[{"given":"Pierre","family":"Debeaudrap","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Etoundi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Tegbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Assoumou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelica","family":"Dialo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristophane","family":"Tanon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Bonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hortense","family":"Aka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Coffie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,8]]},"reference":[{"issue":"9635","key":"19020_CR1","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0140-6736(08)61113-7","volume":"372","author":"The Antiretroviral Therapy Cohort Collaboration","year":"2008","unstructured":"The Antiretroviral Therapy Cohort Collaboration. 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