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This study systematically identified and summarized published evidence on the cost-effectiveness of physical activity-oriented interventions for improving mental health conditions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Study selection and analysis<\/jats:title>\n            <jats:p>We searched four databases (PubMed\/Medline, Science Direct, PsychArticles, PsychINFO) for published studies (from any time and region) that (1) assessed physical activity-oriented interventions in mental health disorders, (2) undertook a full economic evaluation (and specifically cost-effectiveness analysis or cost-utility analysis), and (3) were in English. Data were extracted from included studies using a predetermined 32-item matrix using the Covidence software platform.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Findings<\/jats:title>\n            <jats:p>Search and screening resulted in 11 studies eligible for inclusion. The incremental cost-effectiveness ratio ranged from \u00a3119 to \u00a3152,822 per quality-adjusted life year (QALY) gained. Physical activity interventions, including group sessions, such as dance exercise and walking, or one-on-one support through telephone or web-based personalized support and guidance, were found to be cost-effective. However, over half of the interventions (55%) were considered to be not cost-effective.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our review found that the current evidence is insufficient to conclude whether physical activity-oriented interventions for mental health are a cost-effective when compared with the standard of care of other treatment types. Better designed studies focusing on specific mental health conditions and physical activity interventions that address cost-effectiveness analysis are warranted. Physical activity-oriented interventions for improving mental health should adopt low-cost implementation strategies and include behavioral economics components.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12889-025-22207-3","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T10:51:46Z","timestamp":1747133506000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cost-effectiveness of physical activity-oriented interventions for improving mental health: a systematic review"],"prefix":"10.1186","volume":"25","author":[{"given":"Noara","family":"Alhusseini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy Kuo","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalin","family":"Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Altwaijri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baian A.","family":"Baattaiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Bruckner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"AlAhmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"Alkabbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem F.","family":"Alsukait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkan","family":"Cetinkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazzaa M.","family":"Al-Hazzaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh A.","family":"Alqahtani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"22207_CR1","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1016\/S0140-6736(18)31612-X","volume":"392","author":"V Patel","year":"2018","unstructured":"Patel V, Saxena S, Lund C, Thornicroft G, Baingana F, Bolton P, et al. 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This is a desk-based study with no human subject involvement; as such, no ethics approval was required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human ethics and consent to participate"}},{"value":"The findings, interpretations, and conclusions expressed in this work are those of the authors, and do not necessarily reflect the views of King Faisal Specialist Hospital and Research Center or the World Bank, their Boards of Directors, or the governments they represent.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}],"article-number":"1766"}}