{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T01:52:49Z","timestamp":1776390769742,"version":"3.51.2"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Shandong Provincial Medical and Health Science and Technology Development Project"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Public Health"],"DOI":"10.1186\/s12889-026-26875-7","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:15:05Z","timestamp":1773195305000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors associated with the willingness to accept tuberculosis preventive treatment among close contacts in Yantai, China: a cross-sectional study"],"prefix":"10.1186","volume":"26","author":[{"given":"Xiaohua","family":"Ren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihui","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuelei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"26875_CR1","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/S0140-6736(24)02479-6","volume":"405","author":"A Trajman","year":"2025","unstructured":"Trajman A, Campbell JR, Kunor T, Ruslami R, Amanullah F, Behr MA, et al. Tuberculosis Lancet. 2025;405:850\u201366. https:\/\/doi.org\/10.1016\/S0140-6736(24)02479-6.","journal-title":"Tuberculosis Lancet"},{"key":"26875_CR2","doi-asserted-by":"publisher","DOI":"10.54394\/CJQU6666","volume-title":"Global Tuberculosis Report 2024","author":"World Health Organization","year":"2024","unstructured":"World Health Organization. Global Tuberculosis Report 2024. 1st ed. Geneva: World Health Organization; 2024.","edition":"1"},{"key":"26875_CR3","doi-asserted-by":"publisher","first-page":"e1002152","DOI":"10.1371\/journal.pmed.1002152","volume":"13","author":"RMGJ Houben","year":"2016","unstructured":"Houben RMGJ, Dodd PJ. The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical Modelling. PLoS Med. 2016;13:e1002152. https:\/\/doi.org\/10.1371\/journal.pmed.1002152.","journal-title":"PLoS Med"},{"key":"26875_CR4","unstructured":"Pdrtiru. Decoding the WHO Global Tuberculosis Report 2024: A Critical Analysis of Global and Chinese Key Data. Zoonoses Journal. 2025. https:\/\/zoonoses-journal.org\/index.php\/2025\/01\/09\/global-tuberculosis-report\/. Accessed 11 Dec 2025."},{"key":"26875_CR5","unstructured":"National People\u2019s Congress of the People\u2019s Republic of China. Law on the Prevention and Treatment of Infectious Diseases. http:\/\/www.npc.gov.cn\/c2\/c30834\/202504\/t20250430_445085.html. Accessed 25 Oct 2025."},{"key":"26875_CR6","first-page":"600","volume":"14","author":"National Disease Control and Prevention Administration","year":"2024","unstructured":"National Disease Control and Prevention Administration. Overview of Nationwide Statutory Infectious Disease Incidence in 2023. Chin J Viral Dis. 2024;14:600.","journal-title":"Chin J Viral Dis"},{"key":"26875_CR7","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.cmi.2023.10.023","volume":"30","author":"A Vasiliu","year":"2024","unstructured":"Vasiliu A, Martinez L, Gupta RK, Hamada Y, Ness T, Kay A, et al. Tuberculosis prevention: current strategies and future directions. Clin Microbiol Infect. 2024;30:1123\u201330. https:\/\/doi.org\/10.1016\/j.cmi.2023.10.023.","journal-title":"Clin Microbiol Infect"},{"key":"26875_CR8","doi-asserted-by":"publisher","unstructured":"Organizat WH. WHO consolidated guidelines on tuberculosis. Module 1: Prevention. Tuberculosis preventive treatment. \u0422\u0411. 2021;86\u201392. https:\/\/doi.org\/10.30978\/TB2021-2-86.","DOI":"10.30978\/TB2021-2-86"},{"key":"26875_CR9","doi-asserted-by":"publisher","first-page":"298","DOI":"10.3855\/jidc.14910","volume":"16","author":"N Sharma","year":"2022","unstructured":"Sharma N, Basu S, Khanna A, Sharma P, Chandra S. The intention to receive tuberculosis preventive therapy in adult household contacts of pulmonary TB patients in Delhi, India. J Infect Dev Ctries. 2022;16:298\u2013304. https:\/\/doi.org\/10.3855\/jidc.14910.","journal-title":"J Infect Dev Ctries"},{"key":"26875_CR10","unstructured":"WHO consolidated guidelines on tuberculosis. Module 1: prevention - tuberculosis preventive treatment, second edition. https:\/\/www.who.int\/publications\/i\/item\/9789240096196. Accessed 1 Dec 2025."},{"key":"26875_CR11","unstructured":"World Health Organization. Implementing the end TB strategy: the essentials, 2022 update. https:\/\/www.who.int\/publications\/i\/item\/9789240065093. Accessed 7 May 2025."},{"key":"26875_CR12","unstructured":"World Health Organization. The End-TB Strategy."},{"key":"26875_CR13","doi-asserted-by":"publisher","first-page":"130","DOI":"10.19982\/j.issn.1000-6621.20240585","volume":"47","author":"L Chen Wei","year":"2025","unstructured":"Chen Wei L, Xiaoqiu XL, Yuhong L, Ni N, Hui Z, et al. Interpretation and explanation about the National Tuberculosis Prevention and Control Plan(2024\u20132030). Chin J Antituberculosis. 2025;47:130\u20136. https:\/\/doi.org\/10.19982\/j.issn.1000-6621.20240585.","journal-title":"Chin J Antituberculosis"},{"key":"26875_CR14","first-page":"918","volume":"39","author":"CHEN Mayisha Daken","year":"2023","unstructured":"Mayisha Daken CHEN, Yanggui L, Deyang ZHANG, Yan C, Mingqin. Analysis of influencing factors of intention to preventive treatment among close contacts of families with pulmonary tuberculosis in Urumqi City from 2021 to 2022. J Prev Med Inform. 2023;39:918\u201325.","journal-title":"J Prev Med Inform"},{"key":"26875_CR15","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.3967\/bes2024.150","volume":"37","author":"J Ren","year":"2024","unstructured":"Ren J, Huang F, Chen H, Zhang H, Sun J, Zhao A, et al. Barriers to the Acceptance of Tuberculosis Preventive Treatment: A Multicenter Cross-sectional Study in China. Biomed Environ Sci. 2024;37:1303\u20139. https:\/\/doi.org\/10.3967\/bes2024.150.","journal-title":"Biomed Environ Sci"},{"key":"26875_CR16","doi-asserted-by":"publisher","first-page":"105774","DOI":"10.1016\/j.puhe.2025.105774","volume":"245","author":"J Jin","year":"2025","unstructured":"Jin J, Liu C, Geng H, Ding Y, Cheng B, Zhou W, et al. Factors associated with acceptance of preventive treatment among college students with latent tuberculosis infection in Shandong, China. Public Health. 2025;245:105774. https:\/\/doi.org\/10.1016\/j.puhe.2025.105774.","journal-title":"Public Health"},{"key":"26875_CR17","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12879-023-08005-5","volume":"23","author":"Y Yuan","year":"2023","unstructured":"Yuan Y, Jin J, Bi X, Geng H, Li S, Zhou C. Factors associated with refusal of preventive therapy after initial willingness to accept treatment among college students with latent tuberculosis infection in Shandong, China. BMC Infect Dis. 2023;23:38. https:\/\/doi.org\/10.1186\/s12879-023-08005-5.","journal-title":"BMC Infect Dis"},{"key":"26875_CR18","doi-asserted-by":"publisher","first-page":"1478251","DOI":"10.3389\/fpubh.2025.1478251","volume":"13","author":"H Xie","year":"2025","unstructured":"Xie H, Wang W, Chen X, Huang D, Yu Q, Luo L. An analysis of knowledge, attitudes, practice and influencing factors for tuberculosis prevention and control among Hainan University students. Front Public Health. 2025;13:1478251. https:\/\/doi.org\/10.3389\/fpubh.2025.1478251.","journal-title":"Front Public Health"},{"key":"26875_CR19","doi-asserted-by":"publisher","first-page":"1249971","DOI":"10.3389\/fpubh.2024.1249971","volume":"12","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Wu J, Hui X, Zhang P, Xue F. Knowledge, attitude, and practice toward tuberculosis prevention and management among household contacts in Suzhou Hospital, Jiangsu province, China. Front Public Health. 2024;12:1249971. https:\/\/doi.org\/10.3389\/fpubh.2024.1249971.","journal-title":"Front Public Health"},{"key":"26875_CR20","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1177\/109019818801500401","volume":"15","author":"KR McLeroy","year":"1988","unstructured":"McLeroy KR, Bibeau D, Steckler A, Glanz K. An Ecological Perspective on Health Promotion Programs. Health Educ Q. 1988;15:351\u201377. https:\/\/doi.org\/10.1177\/109019818801500401.","journal-title":"Health Educ Q"},{"key":"26875_CR21","unstructured":"Alyafei A, Easton-Carr R. The Health Belief Model of Behavior Change. In: StatPearls. StatPearls Publishing; 2024."},{"key":"26875_CR22","doi-asserted-by":"publisher","DOI":"10.4135\/9781473913882","volume-title":"Sampling and choosing cases in qualitative research: a realist approach","author":"N Emmel","year":"2013","unstructured":"Emmel N. Sampling and choosing cases in qualitative research: a realist approach. Los Angeles: SAGE; 2013."},{"key":"26875_CR23","doi-asserted-by":"publisher","first-page":"376","DOI":"10.19983\/j.issn.2096-8493.2024022","volume":"5","author":"National Health and Family Planning Commission","year":"2024","unstructured":"National Health and Family Planning Commission. WS 288\u20132017 Diagnosis of Tuberculosis. J Tuberculosis Lung Disease. 2024;5:376\u20138. https:\/\/doi.org\/10.19983\/j.issn.2096-8493.2024022.","journal-title":"J Tuberculosis Lung Disease"},{"key":"26875_CR24","doi-asserted-by":"publisher","first-page":"107196","DOI":"10.1016\/j.ijid.2024.107196","volume":"147","author":"H Chen","year":"2024","unstructured":"Chen H, Zhang H, Cheng J, Sun D, Wang Q, Wu C, et al. Adherence to preventive treatment for latent tuberculosis infection in close contacts of pulmonary tuberculosis patients: A cluster-randomized controlled trial in China. Int J Infect Dis. 2024;147:107196. https:\/\/doi.org\/10.1016\/j.ijid.2024.107196.","journal-title":"Int J Infect Dis"},{"key":"26875_CR25","unstructured":"Chinese Center for Disease Control and Prevention. Core Information and Key Knowledge Points on Tuberculosis Prevention and Control. https:\/\/www.chinacdc.cn\/jkkp\/crb\/ycr\/202409\/t20240925_300847.html. Accessed 11 Dec 2025."},{"key":"26875_CR26","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1093\/cid\/ciz1044","volume":"71","author":"MR Reichler","year":"2020","unstructured":"Reichler MR, Khan A, Yuan Y, Chen B, McAuley J, Mangura B, et al. Duration of Exposure Among Close Contacts of Patients With Infectious Tuberculosis and Risk of Latent Tuberculosis Infection. Clin Infect Dis. 2020;71:1627\u201334. https:\/\/doi.org\/10.1093\/cid\/ciz1044.","journal-title":"Clin Infect Dis"},{"key":"26875_CR27","doi-asserted-by":"publisher","first-page":"12","DOI":"10.19347\/j.cnki.2096-1413.201702006","volume":"2","author":"Wen Jinying","year":"2017","unstructured":"Wen Jinying. Investigation on the acceptance of preventive treatment and its influencing factors among close contacts of tuberculosis patients. Clin Res Pract. 2017;2:12\u20133. https:\/\/doi.org\/10.19347\/j.cnki.2096-1413.201702006.","journal-title":"Clin Res Pract"},{"key":"26875_CR28","doi-asserted-by":"publisher","unstructured":"Jones NT, Abadie R, Keller CL, Jones K, Ledet LF III, Fox JE et al. Treatment and Toxicity Considerations in Tuberculosis: A Narrative Review. Cureus 16:e62698. https:\/\/doi.org\/10.7759\/cureus.62698","DOI":"10.7759\/cureus.62698"},{"key":"26875_CR29","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/S1473-3099(19)30575-4","volume":"20","author":"JR Campbell","year":"2020","unstructured":"Campbell JR, Trajman A, Cook VJ, Johnston JC, Adjobimey M, Ruslami R, et al. Adverse events in adults with latent tuberculosis infection receiving daily rifampicin or isoniazid: post-hoc safety analysis of two randomised controlled trials. Lancet Infect Dis. 2020;20:318\u201329. https:\/\/doi.org\/10.1016\/S1473-3099(19)30575-4.","journal-title":"Lancet Infect Dis"},{"key":"26875_CR30","first-page":"503","volume":"42","author":"REN Zhewen","year":"2020","unstructured":"Zhewen REN, Guolong ZHANG, Dehua GONG, Rongrong LEI, Xiaowen ZU, Caihong XU, et al. Acceptability of preventive treatment with 12-week regimen among close contacts of tuberculosis. Chin J Antituberculosis. 2020;42:503\u20139.","journal-title":"Chin J Antituberculosis"},{"key":"26875_CR31","doi-asserted-by":"publisher","first-page":"94","DOI":"10.19871\/j.cnki.xfcrbzz.2025.01.019","volume":"10","author":"National Disease Control and Prevention Administration, National Health Commission of the People\u2019s Republic of China, National Development and Reform Commission","year":"2025","unstructured":"National Disease Control and Prevention Administration, National Health Commission of the People\u2019s Republic of China, National Development and Reform Commission. National tuberculosis prevention and control plan(2024\u20132030). Electron J Emerg Infect Dis. 2025;10:94. https:\/\/doi.org\/10.19871\/j.cnki.xfcrbzz.2025.01.019.","journal-title":"Electron J Emerg Infect Dis"},{"key":"26875_CR32","first-page":"741","volume":"43","author":"WEI Qian","year":"2021","unstructured":"Qian WEI, Shi-chang WANG, Chuan-bing CAO. Analysis of the investigation results on the public awareness rate of key messages of tuberculosis prevention and treatment in Shandong in 2020. Chin J Antituberculosis. 2021;43:741\u20136.","journal-title":"Chin J Antituberculosis"},{"key":"26875_CR33","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1097\/PHH.0000000000000366","volume":"23","author":"J Manganello","year":"2017","unstructured":"Manganello J, Gerstner G, Pergolino K, Graham Y, Falisi A, Strogatz D. The Relationship of Health Literacy With Use of Digital Technology for Health Information: Implications for Public Health Practice. J Public Health Manage Pract. 2017;23:380. https:\/\/doi.org\/10.1097\/PHH.0000000000000366.","journal-title":"J Public Health Manage Pract"},{"key":"26875_CR34","doi-asserted-by":"publisher","first-page":"e17246","DOI":"10.2196\/17246","volume":"8","author":"L Keutzer","year":"2020","unstructured":"Keutzer L, Wicha SG, Simonsson US. Mobile Health Apps for Improvement of Tuberculosis Treatment: Descriptive Review. JMIR Mhealth Uhealth. 2020;8:e17246. https:\/\/doi.org\/10.2196\/17246.","journal-title":"JMIR Mhealth Uhealth"},{"key":"26875_CR35","doi-asserted-by":"publisher","first-page":"266","DOI":"10.46234\/ccdcw2023.048","volume":"5","author":"C Xu","year":"2023","unstructured":"Xu C, Xia Y, Hu D, Zhang X, Zhao Y. Financial Burden of Tuberculosis Patients \u2014 China, 2020. China CDC Wkly. 2023;5:266\u201370. https:\/\/doi.org\/10.46234\/ccdcw2023.048.","journal-title":"China CDC Wkly"},{"key":"26875_CR36","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.cmi.2024.06.003","volume":"30","author":"C Zhang","year":"2024","unstructured":"Zhang C, Liu Y, Yao Y, Gong D, Lei R, Xia Y, et al. Tuberculosis infection among close contacts of patients with pulmonary tuberculosis in China: a population-based, multicentered study. Clin Microbiol Infect. 2024;30:1176\u201382. https:\/\/doi.org\/10.1016\/j.cmi.2024.06.003.","journal-title":"Clin Microbiol Infect"},{"key":"26875_CR37","doi-asserted-by":"publisher","first-page":"5888","DOI":"10.3390\/jcm10245888","volume":"10","author":"P Caraux-Paz","year":"2021","unstructured":"Caraux-Paz P, Diamantis S, de Wazi\u00e8res B, Gallien S. Tuberculosis in the Elderly. J Clin Med. 2021;10:5888. https:\/\/doi.org\/10.3390\/jcm10245888.","journal-title":"J Clin Med"},{"key":"26875_CR38","doi-asserted-by":"publisher","first-page":"4202","DOI":"10.1002\/cncr.31733","volume":"124","author":"JK Papadakos","year":"2018","unstructured":"Papadakos JK, Hasan SM, Barnsley J, Berta W, Fazelzad R, Papadakos CJ, et al. Health literacy and cancer self-management behaviors: A scoping review. Cancer. 2018;124:4202\u201310. https:\/\/doi.org\/10.1002\/cncr.31733.","journal-title":"Cancer"},{"key":"26875_CR39","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1186\/s12879-023-08612-2","volume":"23","author":"A Manoharan","year":"2023","unstructured":"Manoharan A, Siti Nur Farhana H, Manimaran K, Khoo EM, Koh WM. Facilitators and barriers for tuberculosis preventive treatment among patients with latent tuberculosis infection: a qualitative study. BMC Infect Dis. 2023;23:624. https:\/\/doi.org\/10.1186\/s12879-023-08612-2.","journal-title":"BMC Infect Dis"},{"key":"26875_CR40","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.5588\/ijtld.14.0166","volume":"18","author":"A Rubinowicz","year":"2014","unstructured":"Rubinowicz A, Bartlett G, MacGibbon B, Greenaway C, Ronald L, Munoz M, et al. Evaluating the role of primary care physicians in the treatment of latent tuberculosis: a population study. Int J Tuberc Lung Dis. 2014;18:1449\u201354. https:\/\/doi.org\/10.5588\/ijtld.14.0166.","journal-title":"Int J Tuberc Lung Dis"},{"key":"26875_CR41","doi-asserted-by":"publisher","first-page":"3408","DOI":"10.1016\/j.vaccine.2018.03.009","volume":"36","author":"World Health Organization","year":"2018","unstructured":"World Health Organization. BCG vaccine: WHO position paper, February 2018 \u2013 Recommendations. Vaccine. 2018;36:3408\u201310. https:\/\/doi.org\/10.1016\/j.vaccine.2018.03.009.","journal-title":"Vaccine"},{"key":"26875_CR42","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.1186\/s12889-025-23859-x","volume":"25","author":"K Bisset","year":"2025","unstructured":"Bisset K, Chisnall G, Campbell CNJ, Saliba V, Mounier-Jack S, Chantler T. Parents\u2019 perspectives of the new neonatal BCG vaccination pathway in England: a qualitative study. BMC Public Health. 2025;25:2821. https:\/\/doi.org\/10.1186\/s12889-025-23859-x.","journal-title":"BMC Public Health"}],"container-title":["BMC Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12889-026-26875-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12889-026-26875-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12889-026-26875-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T01:09:56Z","timestamp":1776388196000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12889-026-26875-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["26875"],"URL":"https:\/\/doi.org\/10.1186\/s12889-026-26875-7","relation":{},"ISSN":["1471-2458"],"issn-type":[{"value":"1471-2458","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,11]]},"assertion":[{"value":"19 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study complied with the Declaration of Helsinki and was approved by the Ethical Review Committee of the Yantai Center for Disease Control and Prevention (Ethics Review Approval Number: YYLLS K2024-06). Signed informed consent was obtained from the respondents and personal information was kept confidential. All participants were informed of their test results and counseling was provided for those who needed chest X-ray, sputum examination and preventive treatment.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1264"}}