{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:59:21Z","timestamp":1770487161306,"version":"3.49.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12890-016-0200-x","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T15:28:29Z","timestamp":1458314909000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A randomized, double-blinded, double-dummy efficacy and safety study of budesonide\u2013formoterol Spiromax\u00ae compared to budesonide\u2013formoterol Turbuhaler\u00ae in adults and adolescents with persistent asthma"],"prefix":"10.1186","volume":"16","author":[{"given":"J. Christian","family":"Virchow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Rodriguez-Roisin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Papi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tushar P.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokul","family":"Gopalan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,3,17]]},"reference":[{"key":"200_CR1","unstructured":"Global Initiative for Asthma (GINA). 2015 update. http:\/\/www.ginasthma.org\/local\/uploads\/files\/GINA_Report_2015_Aug11.pdf Accessed 7 Mar 2016."},{"key":"200_CR2","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1056\/NEJM199711133372001","volume":"337","author":"RA Pauwels","year":"1997","unstructured":"Pauwels RA, L\u00f6fdahl CG, Postma DS, Tattersfield AE, O\u2019Byrne P, Barnes PJ, et al. FACET study: effect of inhaled formoterol and budesonide on exacerbations of asthma. N Engl J Med. 1997;337:1405\u201311.","journal-title":"N Engl J Med"},{"key":"200_CR3","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0140-6736(06)69284-2","volume":"368","author":"KF Rabe","year":"2006","unstructured":"Rabe KF, Atienza T, Magyar P, Larsson P, Jorup P, Lalloo UG. Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: a randomised, controlled, double-blind study. Lancet. 2006;368:744\u201353.","journal-title":"Lancet"},{"key":"200_CR4","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1183\/09031936.03.00027003","volume":"22","author":"PM Calverley","year":"2003","unstructured":"Calverley PM, Boonsawat W, Cseke Z, Zhong N, Peterson S, Olsson H. Maintenance therapy with budesonide and formoterol in chronic obstructive pulmonary disease. Eur Respir J. 2003;22:912\u20139.","journal-title":"Eur Respir J"},{"issue":"4","key":"200_CR5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.rmed.2007.11.003","volume":"102","author":"F Lavorini","year":"2008","unstructured":"Lavorini F, Magnan A, Dubus JC, Voshaar T, Corbetta L, Broeders M, et al. Effect of incorrect use of dry powder inhalers on management of patients with asthma and COPD. Respir Med. 2008;102(4):593\u2013604.","journal-title":"Respir Med"},{"key":"200_CR6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1053\/rmed.2001.1276","volume":"96","author":"SP Newman","year":"2002","unstructured":"Newman SP, Busse W. Evolution of dry powder inhaler design, formulation, and performance. Respir Med. 2002;96:293\u2013304.","journal-title":"Respir Med"},{"key":"200_CR7","first-page":"101","volume":"119","author":"GK Crompton","year":"1982","unstructured":"Crompton GK. Problems patients have using pressurized aerosol inhalers. Eur J Respir Dis Suppl. 1982;119:101\u20134.","journal-title":"Eur J Respir Dis Suppl"},{"key":"200_CR8","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.rmed.2006.01.008","volume":"100","author":"GK Crompton","year":"2006","unstructured":"Crompton GK, Barnes PJ, Broeders M, Corrigan C, Corbetta L, Dekhuijzen R, et al. The need to improve inhalation technique in Europe: a report from the Aerosol Drug Management Improvement Team. Respir Med. 2006;100:1479\u201394.","journal-title":"Respir Med"},{"key":"200_CR9","unstructured":"Canonica GW, Arp J, Keegstra H, Chrystyn H. Spiromax, a new dry powder inhaler: dose consistency under simulated real-world conditions. DDL 24. 2013;Abstract 66."},{"key":"200_CR10","unstructured":"DuoResp Spiromax. Summary of product characteristics. http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Product_Information\/human\/002348\/WC500167182.pdf . Accessed 7 Mar 2016."},{"key":"200_CR11","first-page":"593","volume":"53","author":"L Weisfeld","year":"2015","unstructured":"Weisfeld L, Shu Y, Shah TP. Bioequivalence of budesonide plus formoterol (BF) Spiromax\u00ae and BF Turbohaler\u00ae (with and without charcoal block) in healthy volunteers. Int J Clin Pharmacol Ther. 2015;53:593\u2013602.","journal-title":"Int J Clin Pharmacol Ther"},{"issue":"2","key":"200_CR12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.05.00034805","volume":"26","author":"MR Miller","year":"2005","unstructured":"Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of Spirometry; ATS\/ERS Task Force. Eur Respir J. 2005;26(2):319\u201338.","journal-title":"Eur Respir J"},{"key":"200_CR13","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1034\/j.1399-3003.1999.14d29.x","volume":"14","author":"EF Juniper","year":"1999","unstructured":"Juniper EF, O\u2019Byrne PM, Guyatt GH, Ferrie PJ, King DR. Development and validation of a questionnaire to measure asthma control. Eur Respir J. 1999;14:902\u20137.","journal-title":"Eur Respir J"},{"issue":"1","key":"200_CR14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2165\/00151829-200504010-00005","volume":"4","author":"CM Kozma","year":"2005","unstructured":"Kozma CM, Slaton TL, Monz BU, Hodder R, Reese PR. Development and validation of a patient satisfaction and preference questionnaire for inhalation devices. Treat Respir Med. 2005;4(1):41\u201352.","journal-title":"Treat Respir Med"},{"key":"200_CR15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1136\/thx.47.2.76","volume":"47","author":"EF Juniper","year":"1992","unstructured":"Juniper EF, Guyatt GH, Epstein RS, Ferrie PJ, Jaeschke R, Hiller TK. Evaluation of impairment of health-related quality of life in asthma: development of a questionnaire for use in clinical trials. Thorax. 1992;47:76\u201383.","journal-title":"Thorax"},{"issue":"5","key":"200_CR16","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1378\/chest.115.5.1265","volume":"115","author":"EF Juniper","year":"1999","unstructured":"Juniper EF, Buist AS, Cox FM, Ferrie PJ, King DR. Validation of a standardised version of the Asthma Quality of Life Questionnaire. Chest. 1999;115(5):1265\u201370.","journal-title":"Chest"},{"key":"200_CR17","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.2165\/00003495-200464140-00006","volume":"64","author":"DR Goldsmith","year":"2004","unstructured":"Goldsmith DR, Keating GM. Budesonide\/formoterol: a review of its use in asthma. Drugs. 2004;64:1597\u2013618.","journal-title":"Drugs"},{"key":"200_CR18","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/joim.12067","volume":"273","author":"K Larsson","year":"2013","unstructured":"Larsson K, Janson C, Lisspers K, J\u00f8rgensen L, Stratelis G, Telg G, et al. Combination of budesonide\/formoterol more effective than fluticasone\/salmeterol in preventing exacerbations in chronic obstructive pulmonary disease: the PATHOS study. J Intern Med. 2013;273:584\u201394.","journal-title":"J Intern Med"},{"key":"200_CR19","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1365-2125.2012.04167.x","volume":"73","author":"B Vrijens","year":"2012","unstructured":"Vrijens B, De Geest S, Hughes DA, Przemyslaw K, Demonceau J, Ruppar T, et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012;73:691\u2013705.","journal-title":"Br J Clin Pharmacol"},{"key":"200_CR20","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ccm.2012.06.002","volume":"33","author":"LP Boulet","year":"2012","unstructured":"Boulet LP, Vervloet D, Magar Y, Foster JM. Adherence: the goal to control asthma. Clin Chest Med. 2012;33:405\u201317.","journal-title":"Clin Chest Med"},{"key":"200_CR21","volume-title":"A new methodology for assessing mastery and maintenance of dry powder inhaler technique in adults with asthma","author":"D Price","year":"2014","unstructured":"Price D, Gopalan G, Shah T, Rehnstrom K, Kreuzaler S, Burden A, et al. A new methodology for assessing mastery and maintenance of dry powder inhaler technique in adults with asthma. Liverpool: Presented at the Respiratory Effective Group Research Summit; 2014."}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-016-0200-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T04:37:15Z","timestamp":1498279035000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomedcentral.com\/1471-2466\/16\/42"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,17]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["200"],"URL":"https:\/\/doi.org\/10.1186\/s12890-016-0200-x","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,17]]},"article-number":"42"}}