{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:18:05Z","timestamp":1756995485361,"version":"3.37.3"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12890-018-0757-7","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T06:51:29Z","timestamp":1544597489000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pulmonary carcinosarcoma showing an obvious response to pazopanib: a case report"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6643-3867","authenticated-orcid":false,"given":"Azusa","family":"Tanimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kotani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaname","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadaaki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koushiro","family":"Ohtsubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Ebi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Yano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,12]]},"reference":[{"key":"757_CR1","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/S0025-6196(12)62410-0","volume":"59","author":"MP Davis","year":"1984","unstructured":"Davis MP, Eagan RT, Weiland LH, Pairolero PC. Carcinosarcoma of the lung: Mayo Clinic experience and response to chemotherapy. Mayo Clin Proc. 1984;59:598\u2013603.","journal-title":"Mayo Clin Proc"},{"key":"757_CR2","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1097\/00000478-199912000-00009","volume":"23","author":"MN Koss","year":"1999","unstructured":"Koss MN, Hochholzer L, Frommelt RA. Carcinosarcomas of the lung: a clinicopathologic study of 66 patients. Am J Surg Pathol. 1999;23:1514\u201326.","journal-title":"Am J Surg Pathol"},{"key":"757_CR3","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1097\/00000478-200204000-00015","volume":"26","author":"S Dacic","year":"2002","unstructured":"Dacic S, Finkelstein SD, Sasatomi E, Swalsky PA, Yousem SA. Molecular pathogenesis of pulmonary carcinosarcoma as determined by microdissection-based allelotyping. Am J Surg Pathol. 2002;26:510\u20136.","journal-title":"Am J Surg Pathol"},{"key":"757_CR4","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1097\/PDM.0b013e31815d05b3","volume":"17","author":"J Pardo","year":"2008","unstructured":"Pardo J, Aisa G, de Alava E, Sola JJ, Panizo A, Rodriguez-Spiteri N, et al. Primary mixed squamous carcinoma and osteosarcoma (carcinosarcomas) of the lung have a CGH mapping similar to primitive squamous carcinomas and osteosarcomas. Diagnostic Mol Pathol B. 2008;17:151\u20138.","journal-title":"Diagnostic Mol Pathol B"},{"key":"757_CR5","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1016\/S0140-6736(12)60651-5","volume":"379","author":"WT Graaf van der","year":"2012","unstructured":"van der Graaf WT, Blay JY, Chawla SP, Kim DW, Bui-Nguyen B, Casali PG, et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet (London, England). 2012;379:1879\u201386.","journal-title":"Lancet (London, England)"},{"key":"757_CR6","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1056\/NEJMoa1303989","volume":"369","author":"RJ Motzer","year":"2013","unstructured":"Motzer RJ, Hutson TE, Cella D, Reeves J, Hawkins R, Guo J, et al. Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med. 2013;369:722\u201331.","journal-title":"N Engl J Med"},{"key":"757_CR7","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1177\/1066896908330049","volume":"18","author":"G Pelosi","year":"2010","unstructured":"Pelosi G, Sonzogni A, De Pas T, Galetta D, Veronesi G, Spaggiari L, et al. Review article: pulmonary sarcomatoid carcinomas: a practical overview. Int J Surg Pathol. 2010;18:103\u201320.","journal-title":"Int J Surg Pathol"},{"key":"757_CR8","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.athoracsur.2007.03.099","volume":"84","author":"LW Martin","year":"2007","unstructured":"Martin LW, Correa AM, Ordonez NG, Roth JA, Swisher SG, Vaporciyan AA, et al. Sarcomatoid carcinoma of the lung: a predictor of poor prognosis. Ann Thorac Surg. 2007;84:973\u201380.","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"757_CR9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1093\/ajcp\/108.1.40","volume":"108","author":"MR Wick","year":"1997","unstructured":"Wick MR, Ritter JH, Humphrey PA. Sarcomatoid carcinomas of the lung: a clinicopathologic review. Am J Clin Pathol. 1997;108(1):40\u201353.","journal-title":"Am J Clin Pathol"},{"key":"757_CR10","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1097\/PAP.0b013e318216980c","volume":"18","author":"A Weissferdt","year":"2011","unstructured":"Weissferdt A, Moran CA. Malignant biphasic tumors of the lungs. Adv Anat Pathol. 2011;18:179\u201389.","journal-title":"Adv Anat Pathol"},{"key":"757_CR11","first-page":"3893","volume":"26","author":"F Langer","year":"2006","unstructured":"Langer F, Wintzer HO, Werner M, Weber C, Brummendorf TH, Bokemeyer C. A case of pulmonary carcinosarcoma (squamous cell carcinoma and osteosarcoma) treated with cisplatin and doxorubicin. Anticancer Res. 2006;26:3893\u20137.","journal-title":"Anticancer Res"},{"key":"757_CR12","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1186\/1477-7819-11-252","volume":"11","author":"SY Huang","year":"2013","unstructured":"Huang SY, Shen SJ, Li XY. Pulmonary sarcomatoid carcinoma: a clinicopathologic study and prognostic analysis of 51 cases. World J Surg Oncol. 2013;11:252.","journal-title":"World J Surg Oncol"},{"key":"757_CR13","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.lungcan.2013.06.013","volume":"81","author":"G Toyokawa","year":"2013","unstructured":"Toyokawa G, Takenoyama M, Taguchi K, Arakaki K, Inamasu E, Toyozawa R, et al. The first case of lung carcinosarcoma harboring in-frame deletions at exon19 in the EGFR gene. Lung Cancer (Amsterdam, Netherlands). 2013;81:491\u20134.","journal-title":"Lung Cancer (Amsterdam, Netherlands)"},{"key":"757_CR14","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s11912-007-0007-2","volume":"9","author":"G Sonpavde","year":"2007","unstructured":"Sonpavde G, Hutson TE. Pazopanib: a novel multitargeted tyrosine kinase inhibitor. Curr Oncol Rep. 2007;9:115\u20139.","journal-title":"Curr Oncol Rep"},{"key":"757_CR15","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.ygyno.2006.11.001","volume":"105","author":"D Cimbaluk","year":"2007","unstructured":"Cimbaluk D, Rotmensch J, Scudiere J, Gown A, Bitterman P. Uterine carcinosarcoma: immunohistochemical studies on tissue microarrays with focus on potential therapeutic targets. Gynecol Oncol. 2007;105:138\u201344.","journal-title":"Gynecol Oncol"},{"key":"757_CR16","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1600-0463.2008.00757.x","volume":"116","author":"V Nayha","year":"2008","unstructured":"Nayha V, Stenback F. Angiogenesis and expression of angiogenic agents in uterine and ovarian carcinosarcomas. APMIS. 2008;116:107\u201317.","journal-title":"APMIS"},{"key":"757_CR17","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.ygyno.2014.02.036","volume":"133","author":"SM Campos","year":"2014","unstructured":"Campos SM, Brady WE, Moxley KM, O'Cearbhaill RE, Lee PS, DiSilvestro PA, et al. A phase II evaluation of pazopanib in the treatment of recurrent or persistent carcinosarcoma of the uterus: a gynecologic oncology group study. Gynecol Oncol. 2014;133:537\u201341.","journal-title":"Gynecol Oncol"},{"key":"757_CR18","doi-asserted-by":"publisher","first-page":"e25","DOI":"10.3802\/jgo.2017.28.e25","volume":"28","author":"T Nishikawa","year":"2017","unstructured":"Nishikawa T, Hasegawa K, Yabuno A, Yoshida H, Yasuda M, Kozawa E, et al. Pazopanib as a second line treatment for uterine and ovarian carcinosarcoma: a single institutional study. J Gynecol Oncol. 2017;28:e25.","journal-title":"J Gynecol Oncol"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-018-0757-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12890-018-0757-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-018-0757-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T19:09:17Z","timestamp":1576091357000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/s12890-018-0757-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["757"],"URL":"https:\/\/doi.org\/10.1186\/s12890-018-0757-7","relation":{},"ISSN":["1471-2466"],"issn-type":[{"type":"electronic","value":"1471-2466"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"16 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"193"}}