{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T16:18:41Z","timestamp":1781367521870,"version":"3.54.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss Lung Association, Berne, Switzerland"},{"name":"Lunge Z\u00fcrich, Switzerland"},{"name":"Klinik Barmelweid, Switzerland"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12890-019-0817-7","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T10:06:06Z","timestamp":1551434766000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of a long-term home-based exercise training programme using minimal equipment vs. usual care in COPD patients: a study protocol for two multicentre randomised controlled trials (HOMEX-1 and HOMEX-2 trials)"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7134-1000","authenticated-orcid":false,"given":"Anja","family":"Frei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Radtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaba","family":"Dalla Lana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona M.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo A.","family":"Puhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,1]]},"reference":[{"key":"817_CR1","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1164\/rccm.201309-1634ST","volume":"188","author":"MA Spruit","year":"2013","unstructured":"Spruit MA, Singh SJ, Garvey C, ZuWallack R, Nici L, Rochester C, et al. An official American Thoracic Society\/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med. 2013;188:e13\u201364. \n                    https:\/\/doi.org\/10.1164\/rccm.201309-1634ST\n                    \n                  .","journal-title":"Am J Respir Crit Care Med"},{"key":"817_CR2","doi-asserted-by":"publisher","unstructured":"McCarthy B, Casey D, Devane D, Murphy K, Murphy E, Lacasse Y. Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2015:CD003793. \n                    https:\/\/doi.org\/10.1002\/14651858.CD003793.pub3\n                    \n                  .","DOI":"10.1002\/14651858.CD003793.pub3"},{"key":"817_CR3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1177\/1479972310393756","volume":"8","author":"A Keating","year":"2011","unstructured":"Keating A, Lee A, Holland AE. What prevents people with chronic obstructive pulmonary disease from attending pulmonary rehabilitation? A systematic review. Chron Respir Dis. 2011;8:89\u201399. \n                    https:\/\/doi.org\/10.1177\/1479972310393756\n                    \n                  .","journal-title":"Chron Respir Dis"},{"key":"817_CR4","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.rmed.2012.11.016","volume":"107","author":"C Hayton","year":"2013","unstructured":"Hayton C, Clark A, Olive S, Browne P, Galey P, Knights E, et al. Barriers to pulmonary rehabilitation: characteristics that predict patient attendance and adherence. Respir Med. 2013;107:401\u20137. \n                    https:\/\/doi.org\/10.1016\/j.rmed.2012.11.016\n                    \n                  .","journal-title":"Respir Med"},{"key":"817_CR5","doi-asserted-by":"publisher","first-page":"15054","DOI":"10.1038\/npjpcrm.2015.54","volume":"25","author":"R Sohanpal","year":"2015","unstructured":"Sohanpal R, Steed L, Mars T, Taylor SJC. Understanding patient participation behaviour in studies of COPD support programmes such as pulmonary rehabilitation and self-management: a qualitative synthesis with application of theory. NPJ Prim Care Respir Med. 2015;25:15054. \n                    https:\/\/doi.org\/10.1038\/npjpcrm.2015.54\n                    \n                  .","journal-title":"NPJ Prim Care Respir Med"},{"key":"817_CR6","doi-asserted-by":"publisher","first-page":"391","DOI":"10.2147\/COPD.S100254","volume":"11","author":"S Bhatt","year":"2016","unstructured":"Bhatt S, Brown A, Hitchcock J, Schumann C, Wells M, Dransfield M. Determinants of successful completion of pulmonary rehabilitation in COPD. Int J Chron Obstruct Pulmon Dis. 2016;11:391. \n                    https:\/\/doi.org\/10.2147\/COPD.S100254\n                    \n                  .","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"817_CR7","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1034\/j.1399-3003.1999.13d27.x","volume":"13","author":"P Young","year":"1999","unstructured":"Young P, Dewse M, Fergusson W, Kolbe J. Respiratory rehabilitation in chronic obstructive pulmonary disease: predictors of nonadherence. Eur Respir J. 1999;13:855\u20139 \n                    http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10362053\n                    \n                  . Accessed 14 Mar 2017.","journal-title":"Eur Respir J"},{"key":"817_CR8","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1183\/09031936.96.09122590","volume":"9","author":"CJ Clark","year":"1996","unstructured":"Clark CJ, Cochrane L, Mackay E. Low intensity peripheral muscle conditioning improves exercise tolerance and breathlessness in COPD. Eur Respir J. 1996;9:2590\u20136 \n                    http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8980974\n                    \n                  . Accessed 13 Mar 2017.","journal-title":"Eur Respir J"},{"key":"817_CR9","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1111\/j.1440-1843.2008.01327.x","volume":"13","author":"A El\u00e7i","year":"2008","unstructured":"El\u00e7i A, B\u00f6rek\u00e7i S, Ovayolu N, Elbek O. The efficacy and applicability of a pulmonary rehabilitation programme for patients with COPD in a secondary-care community hospital. Respirology. 2008;13:703\u20137. \n                    https:\/\/doi.org\/10.1111\/j.1440-1843.2008.01327.x\n                    \n                  .","journal-title":"Respirology"},{"key":"817_CR10","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1080\/003655099444371","volume":"31","author":"CP Engstr\u00f6m","year":"1999","unstructured":"Engstr\u00f6m CP, Persson LO, Larsson S, Sullivan M. Long-term effects of a pulmonary rehabilitation programme in outpatients with chronic obstructive pulmonary disease: a randomized controlled study. Scand J Rehabil Med. 1999;31:207\u201313 \n                    http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10599897\n                    \n                  . Accessed 13 Mar 2017.","journal-title":"Scand J Rehabil Med"},{"key":"817_CR11","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1016\/S0140-6736(94)90568-1","volume":"344","author":"RS Goldstein","year":"1994","unstructured":"Goldstein RS, Gort EH, Stubbing D, Avendano MA, Guyatt GH. Randomised controlled trial of respiratory rehabilitation. Lancet. 1994;344:1394\u20137 \n                    http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7968075\n                    \n                  . Accessed 13 Mar 2017.","journal-title":"Lancet."},{"key":"817_CR12","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0004-9514(07)70003-X","volume":"53","author":"SD O\u2019Shea","year":"2007","unstructured":"O\u2019Shea SD, Taylor NF, Paratz JD. A predominantly home-based progressive resistance exercise program increases knee extensor strength in the short-term in people with chronic obstructive pulmonary disease: a randomised controlled trial. Aust J Physiother. 2007;53:229\u201337. \n                    https:\/\/doi.org\/10.1016\/S0004-9514(07)70003-X\n                    \n                  .","journal-title":"Aust J Physiother"},{"key":"817_CR13","doi-asserted-by":"crossref","unstructured":"Wijkstra PJ, Van Altena R, Kraan J, Otten V, Postma DS, Ko\u00ebter GH. Quality of life in patients with chronic obstructive pulmonary disease improves after rehabilitation at home. Eur Respir J 1994;7:269\u2013273. \n                    http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8162979\n                    \n                  . Accessed 13 Mar 2017.","DOI":"10.1183\/09031936.94.07020269"},{"key":"817_CR14","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1097\/HCR.0b013e3181ac7b9d","volume":"29","author":"AM Fern\u00e1ndez","year":"2009","unstructured":"Fern\u00e1ndez AM, Pascual J, Ferrando C, Arnal A, Vergara I, Sevila V. Home-based pulmonary rehabilitation in very severe COPD. J Cardiopulm Rehabil Prev. 2009;29:325\u201331. \n                    https:\/\/doi.org\/10.1097\/HCR.0b013e3181ac7b9d\n                    \n                  .","journal-title":"J Cardiopulm Rehabil Prev"},{"key":"817_CR15","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1136\/thx.2007.077578","volume":"63","author":"M Sridhar","year":"2008","unstructured":"Sridhar M, Taylor R, Dawson S, Roberts NJ, Partridge MR. A nurse led intermediate care package in patients who have been hospitalised with an acute exacerbation of chronic obstructive pulmonary disease. Thorax. 2008;63:194\u2013200. \n                    https:\/\/doi.org\/10.1136\/thx.2007.077578\n                    \n                  .","journal-title":"Thorax."},{"key":"817_CR16","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1378\/chest.109.2.366","volume":"109","author":"JH Strijbos","year":"1996","unstructured":"Strijbos JH, Postma DS, Van Altena R, Gimeno F, Ko\u00ebter GH. A comparison between an outpatient hospital-based pulmonary rehabilitation program and a home-care pulmonary rehabilitation program in patients with COPD. Chest. 1996;109:366\u201372. \n                    https:\/\/doi.org\/10.1378\/chest.109.2.366\n                    \n                  .","journal-title":"Chest."},{"key":"817_CR17","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1186\/2049-6958-5-6-401","volume":"5","author":"JC Mendes de Oliveira","year":"2010","unstructured":"Mendes de Oliveira JC, Studart Leit\u00e3o Filho FS, Malosa Sampaio LM, Negrinho de Oliveira AC, Hirata RP, Costa D, et al. Outpatient vs. home-based pulmonary rehabilitation in COPD: a randomized controlled trial. Multidiscip Respir Med. 2010;5:401\u20138. \n                    https:\/\/doi.org\/10.1186\/2049-6958-5-6-401\n                    \n                  .","journal-title":"Multidiscip Respir Med"},{"key":"817_CR18","doi-asserted-by":"publisher","first-page":"869","DOI":"10.7326\/0003-4819-149-12-200812160-00006","volume":"149","author":"F Maltais","year":"2008","unstructured":"Maltais F, Bourbeau J, Shapiro S, Lacasse Y, Perrault H, Baltzan M, et al. Effects of home-based pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med. 2008;149:869\u201378 \n                    http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19075206\n                    \n                  . Accessed 13 Mar 2017.","journal-title":"Ann Intern Med"},{"key":"817_CR19","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1136\/thoraxjnl-2016-208514","volume":"72","author":"AE Holland","year":"2017","unstructured":"Holland AE, Mahal A, Hill CJ, Lee AL, Burge AT, Cox NS, et al. Home-based rehabilitation for COPD using minimal resources: a randomised, controlled equivalence trial. Thorax. 2017;72:57\u201365. \n                    https:\/\/doi.org\/10.1136\/thoraxjnl-2016-208514\n                    \n                  .","journal-title":"Thorax."},{"key":"817_CR20","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/resp.13224","volume":"23","author":"F Wuytack","year":"2018","unstructured":"Wuytack F, Devane D, Stovold E, McDonnell M, Casey M, McDonnell TJ, et al. Comparison of outpatient and home-based exercise training programmes for COPD: a systematic review and meta-analysis. Respirology. 2018;23:272\u201383. \n                    https:\/\/doi.org\/10.1111\/resp.13224\n                    \n                  .","journal-title":"Respirology."},{"key":"817_CR21","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S0738-3991(03)00098-3","volume":"52","author":"MA Spruit","year":"2004","unstructured":"Spruit MA, Troosters T, Trappenburg JCA, Decramer M, Gosselink R. Exercise training during rehabilitation of patients with COPD: a current perspective. Patient Educ Couns. 2004;52:243\u20138. \n                    https:\/\/doi.org\/10.1016\/S0738-3991(03)00098-3\n                    \n                  .","journal-title":"Patient Educ Couns"},{"key":"817_CR22","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1164\/rccm.201603-0602OC","volume":"195","author":"M-R G\u00fcell","year":"2017","unstructured":"G\u00fcell M-R, Cejudo P, Ortega F, Puy MC, Rodr\u00edguez-Trigo G, Pijoan JI, et al. Benefits of long-term pulmonary rehabilitation maintenance program in patients with severe chronic obstructive pulmonary disease. Three-year follow-up. Am J Respir Crit Care Med. 2017;195:622\u20139. \n                    https:\/\/doi.org\/10.1164\/rccm.201603-0602OC\n                    \n                  .","journal-title":"Am J Respir Crit Care Med"},{"key":"817_CR23","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/S0140-6736(12)60735-1","volume":"380","author":"AE Bauman","year":"2012","unstructured":"Bauman AE, Reis RS, Sallis JF, Wells JC, Loos RJF, Martin BW. Correlates of physical activity: why are some people physically active and others not? Lancet. 2012;380:258\u201371. \n                    https:\/\/doi.org\/10.1016\/S0140-6736(12)60735-1\n                    \n                  .","journal-title":"Lancet."},{"key":"817_CR24","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1136\/thx.42.10.773","volume":"42","author":"GH Guyatt","year":"1987","unstructured":"Guyatt GH, Berman LB, Townsend M, Pugsley SO, Chambers LW. A measure of quality of life for clinical trials in chronic lung disease. Thorax. 1987;42:773\u20138.","journal-title":"Thorax."},{"key":"817_CR25","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1183\/09031936.00150314","volume":"44","author":"AE Holland","year":"2014","unstructured":"Holland AE, Spruit MA, Troosters T, Puhan MA, Pepin V, Saey D, et al. An official European Respiratory Society\/American Thoracic Society technical standard: field walking tests in chronic respiratory disease. Eur Respir J. 2014;44:1428\u201346. \n                    https:\/\/doi.org\/10.1183\/09031936.00150314\n                    \n                  .","journal-title":"Eur Respir J"},{"key":"817_CR26","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1183\/09031936.00150414","volume":"44","author":"SJ Singh","year":"2014","unstructured":"Singh SJ, Puhan MA, Andrianopoulos V, Hernandes NA, Mitchell KE, Hill CJ, et al. An official systematic review of the European Respiratory Society\/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease. Eur Respir J. 2014;44:1447\u201378. \n                    https:\/\/doi.org\/10.1183\/09031936.00150414\n                    \n                  .","journal-title":"Eur Respir J"},{"key":"817_CR27","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1164\/ajrccm.166.1.at1102","volume":"166","author":"ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories","year":"2002","unstructured":"ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002;166:111\u20137. \n                    https:\/\/doi.org\/10.1164\/ajrccm.166.1.at1102\n                    \n                  .","journal-title":"Am J Respir Crit Care Med"},{"key":"817_CR28","doi-asserted-by":"publisher","first-page":"1601871","DOI":"10.1183\/13993003.01871-2016","volume":"49","author":"S Crook","year":"2017","unstructured":"Crook S, B\u00fcsching G, Schultz K, Lehbert N, Jelusic D, Keusch S, et al. A multicentre validation of the 1-min sit-to-stand test in patients with COPD. Eur Respir J. 2017;49:1601871. \n                    https:\/\/doi.org\/10.1183\/13993003.01871-2016\n                    \n                  .","journal-title":"Eur Respir J"},{"issue":"Suppl 1","key":"817_CR29","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1007\/s10198-013-0502-3","volume":"14","author":"NJ Devlin","year":"2013","unstructured":"Devlin NJ, Krabbe PFM. The development of new research methods for the valuation of EQ-5D-5L. Eur J Heal Econ HEPAC Heal Econ Prev Care. 2013;14(Suppl 1):S1\u20133. \n                    https:\/\/doi.org\/10.1007\/s10198-013-0502-3\n                    \n                  .","journal-title":"Eur J Heal Econ HEPAC Heal Econ Prev Care"},{"key":"817_CR30","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1183\/09031936.00004814","volume":"44","author":"F Dobbels","year":"2014","unstructured":"Dobbels F, De Jong C, Drost E, Elberse J, Feridou C, Jacobs L, et al. The PROactive innovative conceptual framework on physical activity. Eur Respir J. 2014;44:1223\u201333.","journal-title":"Eur Respir J"},{"key":"817_CR31","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1183\/09031936.00183014","volume":"46","author":"E Gimeno-Santos","year":"2015","unstructured":"Gimeno-Santos E, Raste Y, Demeyer H, Louvaris Z, de Jong C, Rabinovich RA, et al. The PROactive instruments to measure physical activity in patients with chronic obstructive pulmonary disease. Eur Respir J. 2015;46:988\u20131000. \n                    https:\/\/doi.org\/10.1183\/09031936.00183014\n                    \n                  .","journal-title":"Eur Respir J"},{"key":"817_CR32","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1183\/09031936.00102509","volume":"34","author":"PW Jones","year":"2009","unstructured":"Jones PW, Harding G, Berry P, Wiklund I, Chen W-H, Kline Leidy N. Development and first validation of the COPD assessment test. Eur Respir J. 2009;34:648\u201354. \n                    https:\/\/doi.org\/10.1183\/09031936.00102509\n                    \n                  .","journal-title":"Eur Respir J"},{"key":"817_CR33","doi-asserted-by":"publisher","unstructured":"Puhan MA, Guyatt GH, Montori VM, Bhandari M, Devereaux PJ, Griffith L, et al. The standard gamble demonstrated lower reliability than the feeling thermometer. J Clin Epidemiol 2005;58:458\u2013465. doi:S0895\u20134356(04)00357\u20139 [pii]\n                    https:\/\/doi.org\/10.1016\/j.jclinepi.2004.07.010\n                    \n                  .","DOI":"10.1016\/j.jclinepi.2004.07.010"},{"key":"817_CR34","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1016\/j.rmed.2004.04.011","volume":"98","author":"MA Puhan","year":"2004","unstructured":"Puhan MA, Behnke M, Devereaux PJ, Montori VM, Braendli O, Frey M, et al. Measurement of agreement on health-related quality of life changes in response to respiratory rehabilitation by patients and physicians--a prospective study. Respir Med. 2004;98:1195\u2013202.","journal-title":"Respir Med"},{"key":"817_CR35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1477-7525-1-29","volume":"1","author":"RP Snaith","year":"2003","unstructured":"Snaith RP. The hospital anxiety and depression scale. Heal Qual Life Outcomes. 2003;1:29. \n                    https:\/\/doi.org\/10.1186\/1477-7525-1-29\n                    \n                  .","journal-title":"Heal Qual Life Outcomes"},{"key":"817_CR36","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1056\/NEJMsm1605385","volume":"377","author":"MA Hern\u00e1n","year":"2017","unstructured":"Hern\u00e1n MA, Robins JM. Per-protocol analyses of pragmatic trials. N Engl J Med. 2017;377:1391\u20138. \n                    https:\/\/doi.org\/10.1056\/NEJMsm1605385\n                    \n                  .","journal-title":"N Engl J Med"},{"key":"817_CR37","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","volume":"42","author":"PA Harris","year":"2009","unstructured":"Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42:377\u201381.","journal-title":"J Biomed Inform"},{"key":"817_CR38","doi-asserted-by":"publisher","first-page":"725","DOI":"10.2147\/COPD.S77368","volume":"10","author":"M Cazzola","year":"2015","unstructured":"Cazzola M, Hanania NA, MacNee W, R\u00fcdell K, Hackford C, Tamimi N. A review of the most common patient-reported outcomes in COPD - revisiting current knowledge and estimating future challenges. Int J Chron Obstruct Pulmon Dis. 2015;10:725\u201338. \n                    https:\/\/doi.org\/10.2147\/COPD.S77368\n                    \n                  .","journal-title":"Int J Chron Obstruct Pulmon Dis"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-019-0817-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12890-019-0817-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-019-0817-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T19:05:51Z","timestamp":1582916751000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/s12890-019-0817-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["817"],"URL":"https:\/\/doi.org\/10.1186\/s12890-019-0817-7","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,1]]},"assertion":[{"value":"6 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Both HOMEX trials were approved by the lead Ethics Committee Kantonale Ethikkommission Z\u00fcrich, and by the local ethics committees Ethikkommission Bern and Ethikkommission Zentral- und Nordwestschweiz, Switzerland (BASEC-Nr. 2017\u201302092). All study participants will provide informed written consent before any study-related procedures are performed. The Ethics Committees will be informed about important protocol modifications for approval.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing or financial interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"57"}}