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Chemical pleurodesis had been the only definitive treatment option until two decades ago. Indwelling pleural catheters (IPC) emerged as an alternative, not only assuring immediate symptom relief but also potentially leading to pleurodesis in the absence of sclerosing agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single-centre retrospective observational study patient characteristics, procedural variables and outcome in a large population of patients with IPC in malignancy were evaluated and prognostic factors for pleurodesis were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2006 to 2016, 395 patients received 448 IPC, of whom 121 (30.6%) had ovarian, 91 (23.0%) lung and 45 (11.4%) breast cancer. The median length of IPC remaining in place was 1.2\u2009months (IQR, 0.5\u20132.6), the median survival time after insertion 2.0\u2009months (IQR, 0.6\u20136.4). An adequate symptom relief was achieved in 94.9% of all patients, with no need for subsequent interventions until last visit or death. In patients surviving \u226530\u2009days after IPC insertion, pleurodesis was observed in 44.5% and was more common in patients &lt;\u200960\u2009years (HR, 1.72; 95% CI, 1.05\u20132.78;<jats:italic>p<\/jats:italic>\u00a0=\u20090.03). The use of an additional talc slurry via the IPC was highly predictive for pleurodesis (HR 6.68; 95% CI, 1.44\u201331.08;<jats:italic>p<\/jats:italic>\u00a0=\u20090.02). Complications occurred in 13.4% of all procedures (<jats:italic>n<\/jats:italic>\u00a0=\u200960), 41.8% concerning infections (local infections at the tunnel\/exit site (<jats:italic>n<\/jats:italic>\u00a0=\u200914) and empyema (<jats:italic>n<\/jats:italic>\u00a0=\u200911)), and 98.3% being low or mild grade (<jats:italic>n<\/jats:italic>\u00a0=\u200959). Complication rates were higher in men than women (18.6 vs. 12.4%,<jats:italic>p<\/jats:italic>\u00a0=\u20090.023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High efficacy in symptom relief and a favourable safety profile confirm IPC as suitable first line option in most malignant pleural effusions. The study presents the largest dataset on IPC in gynaecologic cancer to date. Gender-specific differences in complication rates warrant further study.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12890-019-1002-8","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T15:09:09Z","timestamp":1575299349000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Indwelling pleural catheters for malignancy-associated pleural effusion: report on a single centre\u2019s ten years of experience"],"prefix":"10.1186","volume":"19","author":[{"given":"Nikolaj","family":"Frost","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Br\u00fcnger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Ruwwe-Gl\u00f6senkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Raspe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Tessmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Temmesfeld-Wollbr\u00fcck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Sch\u00fcrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Suttorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Witzenrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"issue":"4","key":"1002_CR1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1183\/09031936.93.02040366","volume":"2","author":"F Rodriguez-Panadero","year":"1989","unstructured":"Rodriguez-Panadero F, Borderas Naranjo F, Lopez Mejias J. 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Patient\u2019s written informed consent was obtained within the treatment contract as IPC insertion was performed as standard of care.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"232"}}