{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:14:20Z","timestamp":1791951260699,"version":"4.3.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T00:00:00Z","timestamp":1576886400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005646","name":"Actelion Pharmaceuticals Ltd","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005646","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>There is little information about vitamin D (Vit D) deficiency in patients with pulmonary hypertension (PH). The objective of this study was: 1) compare Vit D levels between patients with PH, left ventricular failure (LVF) and healthy subjects (HS); 2) correlate, in patients with PH, Vit D levels with prognosis-related variables, such as the 6-min walk test (6MWT).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Vitamin D levels were measured in a cross-sectional study in 126 patients from one of three groups: patients with PH (<jats:italic>n<\/jats:italic>\u00a0=\u200953), patients with LVF (<jats:italic>n<\/jats:italic>\u00a0=\u200942) and healthy subjects (<jats:italic>n<\/jats:italic>\u00a0=\u200931). In all groups, 8-h fasting blood samples were obtained in the morning. In the PH and the LVF group, functional class (WHO criteria), metres covered in the 6MWT and echocardiographic parameters were analysed. In the PH group, plasma N terminal pro B type natriuretic peptide (NT-proBNP) level was analysed and a complete haemodynamic evaluation by right heart catheterisation was made.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Mean Vit D levels were lower in PH than in both other groups (ng\/ml, mean\u2009\u00b1\u2009SD): PH 19.25\u2009\u00b1\u200910, LVF 25.68\u2009\u00b1\u200912, HS 28.8\u2009\u00b1\u200912 (PH vs LVF <jats:italic>p<\/jats:italic>\u00a0=\u20090.017, PH vs HS <jats:italic>p<\/jats:italic>\u00a0=\u20090.001 and HS vs LVF <jats:italic>p<\/jats:italic>\u00a0=\u20090.46). Vit D deficiency prevalence was higher in PH as compared to the other groups (PH 53.8%, LVF 45.2%, HS 25%, p\u2009=\u20090.01). Patients with PH in functional class (FC; WHO criteria) III\u2013IV had higher Vit D deficiency prevalence than those in FC I\u2013II (86.7% vs 40.5%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.003). There was a significant linear correlation between the 6MWT and Vit D levels in PH (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.01), but not in LVF (<jats:italic>p<\/jats:italic>\u00a0=\u20090.69).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Vit D levels were lower in patients with PH as compared to patients with LVF and HS and correlated directly with 6-min walk distance.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-019-1011-7","type":"journal-article","created":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T10:02:43Z","timestamp":1576922563000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Vitamin D deficiency among patients with pulmonary hypertension"],"prefix":"10.1186","volume":"19","author":[{"given":"Andr\u00e9s N.","family":"Atama\u00f1uk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego F.","family":"Litewka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio J.","family":"Baratta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio M.","family":"Seropian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Perez Prados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel O.","family":"Payaslian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.","family":"Ortiz Fragola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Escribano Subias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,21]]},"reference":[{"key":"1011_CR1","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1093\/ije\/10.4.337","volume":"10","author":"R Scragg","year":"1981","unstructured":"Scragg R. 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Fern\u00e1ndez (Research Ethic Committee, Juan A. Fern\u00e1ndez General Hospital) (reference number: CEIHF201930). Verbal informed consent was obtained and registered in the clinical record. Consent was obtained verbally because there was no intervention and the study represented no potential harm or danger to the patients. The IRB approved the verbal method of obtaining consent.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"258"}}