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Our study aimed to examine the association between the OSA and the hospitalization for an MVA injury.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This retrospective cohort study used Taiwan\u2019s National Health Insurance Research Database (NHIRD) between 2000 and 2015. The OSA patients aged \u226520\u2009years by age, sex, and index-year matched by non-OSA controls were enrolled (1:3). We used the Cox proportional regression model to evaluate the association between the OSA and the hospitalization for an MVA injury.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The incidence rate of hospitalization for an MVA injury was higher in the OSA cohort (<jats:italic>N<\/jats:italic>\u2009=\u20093025) when compared with the non-OSA controls (<jats:italic>N<\/jats:italic>\u2009=\u20099075), as 575.3 and 372.0 per 100,000 person-years, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The Kaplan-Meier analysis showed that the OSA cohort had a significantly higher incidence of hospitalization for the MVA injury (log-rank test, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). After adjusting for the covariates, the risk of hospitalization for the MVA injury among the OSA was significantly higher (hazard ratio [HR] =2.18; 95% confidence interval [CI]\u2009=\u20091.79\u20132.64; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Stimulants usage was associated with a nearly 20% decrease in the risk of an overall hospitalization for an MVA injury in the OSA patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study provides evidence that patients with OSA are at a two-fold higher risk of developing hospitalization for an MVA injury, and the usage of modafinil and methylphenidate was associated with a lower risk of an overall hospitalization for the MVA injury.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-019-1041-1","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T15:03:39Z","timestamp":1580742219000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Stimulants associated with reduced risk of hospitalization for motor vehicle accident injury in patients with obstructive sleep apnea-a nationwide cohort study"],"prefix":"10.1186","volume":"20","author":[{"given":"Yi-Chang","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Chien","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Hsiang","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-An","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chen","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Sung","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Sheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5881-7089","authenticated-orcid":false,"given":"Nian-Shen","family":"Tzeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"issue":"9328","key":"1041_CR1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0140-6736(02)09464-3","volume":"360","author":"A Malhotra","year":"2002","unstructured":"Malhotra A, White DP. 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Because the NHIRD has the advantage of providing a large-scale, longitudinal, reliable dataset, leading to extensive use for population-based researches in Taiwan, the Institutional Review Board of Tri-Service General Hospital was aware of this and approved the research to proceed, and also agreed that the benefit justified waiving the need for individual written informed consent in such a study. (IRB No. 1\u2013106\u201305-169).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"28"}}