{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T18:07:16Z","timestamp":1772302036925,"version":"3.50.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Anti-synthetase syndrome (ASS) is an uncommon immune-mediated entity characterized by myositis, interstitial lung disease (ILD), non-erosive arthritis, and less common features such as fever, Raynaud\u2019s phenomenon, and skin changes in association with anti-aminoacyl-transfer-RNA antibodies, most commonly anti-Jo-1 antibodies.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We present a challenging and rare case of ASS-associated ILD presenting with unexplained respiratory symptoms and bilateral infiltrates on chest imaging during the COVID-19 pandemic. High clinical suspicion for ASS with early appropriate therapy with corticosteroids and immunosuppressive agents led to marked clinical improvement.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>High index of suspicion for ASS is mandated in patients with unexplained ILD. A comprehensive autoimmune work-up is important as an early treatment with corticosteroids with or without immunomodulators improves patient outcomes and survival in an otherwise poor prognostic disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-020-01388-0","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T21:03:31Z","timestamp":1609967011000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Anti-synthetase syndrome: a rare and challenging diagnosis for bilateral ground-glass opacities\u2014a case report with literature review"],"prefix":"10.1186","volume":"21","author":[{"given":"Nasam","family":"Alfraji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usman","family":"Mazahir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moiuz","family":"Chaudhri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Miskoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"issue":"3","key":"1388_CR1","doi-asserted-by":"publisher","first-page":"OD08","DOI":"10.7860\/JCDR\/2016\/16872.7361","volume":"10","author":"HG Devi","year":"2016","unstructured":"Devi HG, Pasha MM, Padmaja MS, Halappa S. Anti-synthetase syndrome: a rare cause for ILD. J Clin Diagn Res. 2016;10(3):OD08\u20139. https:\/\/doi.org\/10.7860\/JCDR\/2016\/16872.7361.","journal-title":"J Clin Diagn Res"},{"key":"1388_CR2","doi-asserted-by":"publisher","first-page":"101503","DOI":"10.1016\/j.berh.2020.101503","volume":"10","author":"JL Marco","year":"2020","unstructured":"Marco JL, Collins BF. Clinical manifestations and treatment of antisynthetase syndrome. Best Pract Res Clin Rheumatol. 2020;10:101503. https:\/\/doi.org\/10.1016\/j.berh.2020.101503.","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"6","key":"1388_CR3","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1097\/BOR.0000000000000555","volume":"30","author":"L Gallay","year":"2018","unstructured":"Gallay L, Gayed C, Hervier B. Antisynthetase syndrome pathogenesis: knowledge and uncertainties. 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BMJ Case Rep. 2019;12:e231006. https:\/\/doi.org\/10.1136\/bcr-2019-231006.","journal-title":"BMJ Case Rep"},{"issue":"6","key":"1388_CR8","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1097\/BOR.0000000000000434","volume":"29","author":"S Monti","year":"2017","unstructured":"Monti S, Montecucco C, Cavagna L. Clinical spectrum of anti-Jo-1-associated disease. Curr Opin Rheumatol. 2017;29(6):612\u20137. https:\/\/doi.org\/10.1097\/BOR.0000000000000434.","journal-title":"Curr Opin Rheumatol"},{"issue":"32","key":"1388_CR9","doi-asserted-by":"publisher","first-page":"e1144","DOI":"10.1097\/MD.0000000000001144","volume":"94","author":"L Cavagna","year":"2015","unstructured":"Cavagna L, Nuno L, Scire CA, Govoni M, Longo FJL, Franceschini F, et al. Clinical spectrum time Course in anti Jo-1 positive anti-synthetase syndrome. 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