{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:39:47Z","timestamp":1789925987650,"version":"4.0.1"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Crazy-paving patterns are rarely reported as radiological manifestations of pulmonary cryptococcosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>Herein, we presented a very rare case of a crazy-paving pattern as a radiological manifestation of pulmonary cryptococcosis in a patient with primary ciliary dyskinesia. The diagnosis of pulmonary cryptococcosis and primary ciliary dyskinesia was ultimately confirmed by bronchoscopic biopsy, fungus culture, whole exome sequencing of blood, etc. The patient received flucytosine (PO, 5\u00a0g per day) and amphotericin B (IV, 70\u00a0mg per day) during hospitalization and sequential therapy with voriconazole (PO, 200\u00a0mg twice a day) after discharge. He recovered during follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We concluded that pulmonary cryptococcosis should be considered a possible cause of crazy-paving patterns in chest CT scans.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-021-01450-5","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T07:02:44Z","timestamp":1615532564000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Crazy\u2010paving patterns as rare radiological manifestations of pulmonary cryptococcosis: a case report"],"prefix":"10.1186","volume":"21","author":[{"given":"He","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaige","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjiang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8358-9177","authenticated-orcid":false,"given":"Zongan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"issue":"2","key":"1450_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1093\/mmy\/myy086","volume":"57","author":"F Setianingrum","year":"2019","unstructured":"Setianingrum F, Rautemaa-Richardson R, Denning DW. Pulmonary cryptococcosis: a review of pathobiology and clinical aspects. Med Mycol. 2019;57(2):133\u201350.","journal-title":"Med Mycol"},{"issue":"6","key":"1450_CR2","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1148\/rg.236035101","volume":"23","author":"SE Rossi","year":"2003","unstructured":"Rossi SE, Erasmus JJ, Volpacchio M, Franquet T, Castiglioni T, McAdams HP. \u201cCrazy-paving\u201d pattern at thin-section CT of the lungs: radiologic-pathologic overview. Radiographics. 2003;23(6):1509\u201319.","journal-title":"Radiographics"},{"issue":"2","key":"1450_CR3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s13244-010-0060-5","volume":"2","author":"W De Wever","year":"2011","unstructured":"De Wever W, Meersschaert J, Coolen J, et al. The crazy-paving pattern: a radiological-pathological correlation. 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It was approved by the Clinical Research Ethics Committee of West China Hospital, Sichuan University, Chengdu, Sichuan, China.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare that they they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"84"}}