{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:59:11Z","timestamp":1740135551379,"version":"3.37.3"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Indium is a metal used as a compound called indium-tin oxide for liquid crystal display. Its inhalation causes lung toxicity, resulting in a new occupational lung disease called indium lung. Although the carcinogenicity of indium has been reported in an animal model, its carcinogenicity in humans is unknown.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>This is the first reported case of a primary lung cancer originating from indium lung. In this report, we describe a 46-year-old man with interstitial pneumonia-type indium lung diagnosed 16\u00a0years ago. The initial symptom was left chest pain, and computed tomography showed a mass adjacent to the aorta with left pleural effusion. Specimens collected using video-assisted thoracoscopy revealed an adenocarcinoma with a high expression of programmed cell death-ligand 1 (cT4N0M1a stage IVA). Although the lesions showed a remarkable aggressive nature, the patient benefited from pembrolizumab, a monoclonal antibody against programmed cell death 1, which was used as second-line therapy for 2\u00a0years.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>It is important for clinicians to be aware of lung cancer development in indium-exposed workers or in patients with indium lung, as this could have an aggressive behavior. Treatment with immune checkpoint inhibitors is an option even in patients with interstitial pneumonia-type indium lung.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-021-01474-x","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T11:03:02Z","timestamp":1617188582000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Response to pembrolizumab in a patient with primary lung adenocarcinoma originated from indium lung"],"prefix":"10.1186","volume":"21","author":[{"given":"Yasuharu","family":"Sekine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2779-0108","authenticated-orcid":false,"given":"Hideo","family":"Ichimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Nawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Amata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Chonan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoji","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"1474_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1620\/tjem.248.143","volume":"248","author":"T Chonan","year":"2019","unstructured":"Chonan T, Amata A, Kawabata Y, Omae K. Indium lung: discovery, pathophysiology and prevention. Tohoku J Exp Med. 2019;248:143\u201350.","journal-title":"Tohoku J Exp Med"},{"key":"1474_CR2","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1378\/chest.11-1880","volume":"141","author":"KJ Cummings","year":"2012","unstructured":"Cummings KJ, Nakano M, Omae K, Takeuchi K, Chonan T, Xiao YL, et al. Indium lung disease. Chest. 2012;141:1512\u201321.","journal-title":"Chest"},{"key":"1474_CR3","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1539\/joh.10-0057-OA","volume":"53","author":"K Nagano","year":"2011","unstructured":"Nagano K, Nishizawa T, Umeda Y, Kasai T, Noguchi T, Gotoh K, et al. Inhalation carcinogenicity and chronic toxicity of indium-tin oxide in rats and mice. J Occup Health. 2011;53:175\u201387.","journal-title":"J Occup Health"},{"key":"1474_CR4","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/1348-9585.12050","volume":"61","author":"M Nakano","year":"2019","unstructured":"Nakano M, Omae K, Tanaka A, Hirata M. Possibility of lung cancer risk in indium-exposed workers: an 11-year multicenter cohort study. J Occup Health. 2019;61:251\u20136.","journal-title":"J Occup Health"},{"key":"1474_CR5","first-page":"532","volume":"44","author":"O Taguchi","year":"2006","unstructured":"Taguchi O, Chonan T. Three cases of indium lung. J Jpn Respir Soc. 2006;44:532\u20136 ((in Japanese)).","journal-title":"J Jpn Respir Soc"},{"key":"1474_CR6","first-page":"158","volume":"8","author":"A Amata","year":"2019","unstructured":"Amata A, Chonan T, Yabuuchi Y, Ichimura H, Nawa T, Kawabata Y. A case of lung cancer in a patient with indium lung disease. Ann Jpn Respir Soc. 2019;8:158\u201362 ((in Japanese)).","journal-title":"Ann Jpn Respir Soc"},{"key":"1474_CR7","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.lungcan.2018.09.015","volume":"125","author":"JY Cho","year":"2018","unstructured":"Cho JY, Kim J, Lee JS, Kim YJ, Kim SH, Lee YJ, et al. Characteristics, incidence, and risk factors of immune checkpoint inhibitor-related pneumonitis in patients with non-small cell lung cancer. Lung Cancer. 2018;125:150\u20136.","journal-title":"Lung Cancer"},{"key":"1474_CR8","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.resinv.2019.05.002","volume":"57","author":"Y Nakanishi","year":"2019","unstructured":"Nakanishi Y, Masuda T, Yamaguchi K, Sakamoto S, Horimasu Y, Nakashima T, et al. Pre-existing interstitial lung abnormalities are risk factors for immune checkpoint inhibitor-induced interstitial lung disease in non-small cell lung cancer. Respir Investig. 2019;57:451\u20139.","journal-title":"Respir Investig"},{"key":"1474_CR9","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00184-2019","author":"Y Minegishi","year":"2020","unstructured":"Minegishi Y, Gemma A, Homma S, Kishi K, Azuma A, Ogura T, et al. Acute exacerbation of idiopathic interstitial pneumonias related to chemotherapy for lung cancer: nationwide surveillance in Japan. ERJ Open Res. 2020. https:\/\/doi.org\/10.1183\/23120541.00184-2019.","journal-title":"ERJ Open Res"},{"key":"1474_CR10","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1038\/bjc.2013.514","volume":"109","author":"G Frost","year":"2013","unstructured":"Frost G. The latency period of mesothelioma among a cohort of British asbestos workers (1978\u20132005). 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A copy of the written consent is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"107"}}