{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:30:33Z","timestamp":1781659833823,"version":"3.54.5"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Platypnea-orthodeoxia syndrome (POS) is a rare condition characterized by dyspnoea (platypnea) and arterial desaturation in the upright position resolved in the supine position (orthodeoxia). Intracardiac shunt, pulmonary ventilation\u2013perfusion mismatch and others intrapulmonary abnormalities are involved.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We report a case of POS associated with two pathophysiological issues: one, cardiac POS caused by a patent foramen ovale (PFO) and second, pulmonary POS due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interstitial pneumonia. POS has resolved after recovery of coronavirus disease 2019 (COVID-19) pneumonia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Right-to-left interatrial shunt and intrapulmonary shunt caused by SARS-CoV-2 pneumonia contributed to refractory hypoxemia and POS. Therefore, in case of COVID-19 patient with unexplained POS, the existence of PFO must be investigated.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-021-01494-7","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T11:04:53Z","timestamp":1618830293000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Patent foramen ovale revealed by COVID-19 pneumonia"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5853-8717","authenticated-orcid":false,"given":"Charlotte","family":"Vanhomwegen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Taton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Selvais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0756-0399","authenticated-orcid":false,"given":"Olivier","family":"Vanhove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Leduc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"1494_CR1","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1007\/s00134-020-06033-2","volume":"46","author":"L Gattinoni","year":"2020","unstructured":"Gattinoni L, Chiumello D, Caironi P, Busana M, Romitti F, Brazzi L, et al. COVID-19 pneumonia: different respiratory treatments for different phenotypes? Intensive Care Med. 2020;46:1099\u2013102.","journal-title":"Intensive Care Med"},{"key":"1494_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06102-6","author":"R Rajendram","year":"2020","unstructured":"Rajendram R, Kharal GA, Mahmood N, Puri R, Kharal M. Rethinking the respiratory paradigm of COVID-19: a \u2018hole\u2019 in the argument. Intensive Care Med. 2020. https:\/\/doi.org\/10.1007\/s00134-020-06102-6.","journal-title":"Intensive Care Med"},{"key":"1494_CR3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13613-020-00726-z","volume":"10","author":"P Masi","year":"2020","unstructured":"Masi P, Bagate F, d\u2019Humi\u00e8res T, Al-Assaad L, Abou Chakra L, Derumeaux G, et al. Is hypoxemia explained by intracardiac or intrapulmonary shunt in COVID-19-related acute respiratory distress syndrome? 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Nat Rev Cardiol. 2011;8(3):148\u201360.","journal-title":"Nat Rev Cardiol"},{"key":"1494_CR6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.rmed.2017.05.016","volume":"129","author":"A Agrawal","year":"2017","unstructured":"Agrawal A, Palkar A, Talwar A. The multiple dimensions of Platypnea-Orthodeoxia syndrome: a review. Respir Med. 2017;129:31\u20138.","journal-title":"Respir Med"},{"key":"1494_CR7","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-016-4479-4","author":"R De Vecchis","year":"2017","unstructured":"De Vecchis R, Baldi C, Ariano C, Giasi A, Cioppa C. Platypnea\u2013orthodeoxia syndrome: orthostatic dyspnea and possible pathophysiological substrates. 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