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Bronchiectasis is a heterogeneous disease related to a variety of diseases. Whether bronchiectasis exists and correlates with asthma-CRS patients has not been fully elucidated. The purpose of the study was to explore the presence and characteristics of bronchiectasis in patients with overlapping asthma and CRS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This report describes a prospective study with consecutive asthma-CRS patients. The diagnosis and severity of bronchiectasis were obtained by thorax high-resolution computed tomography (HRCT), the Smith radiology scale and the Bhalla scoring system. CRS severity was evaluated by paranasal sinus CT and the Lund-Mackay (LM) scoring system. The correlations between bronchiectasis and clinical data, fraction of exhaled nitric oxide, peripheral blood eosinophil counts and lung function were analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Seventy-two (40.91%) of 176 asthma-CRS patients were diagnosed with bronchiectasis. Asthma-CRS patients with overlapping bronchiectasis had a higher incidence rate of nasal polyps (NPs) (<jats:italic>P<\/jats:italic>\u2009=\u20090.004), higher LM scores (<jats:italic>P<\/jats:italic>\u2009=\u20090.044), higher proportion of \u2265\u20091 severe exacerbation of asthma in the last 12\u00a0months (<jats:italic>P<\/jats:italic>\u2009=\u20090.003), lower postbronchodilator forced expiratory volume in one second (FEV<jats:sub>1<\/jats:sub>) % predicted (<jats:italic>P<\/jats:italic>\u2009=\u20090.006), and elevated peripheral blood eosinophil counts (<jats:italic>P<\/jats:italic>\u2009=\u20090.022). Smith and Bhalla scores were shown to correlate positively with NPs and negatively with FEV<jats:sub>1<\/jats:sub>% predicted and body mass index. Cutoff values of FEV<jats:sub>1<\/jats:sub>% predicted\u2009\u2264\u200971.40%, peripheral blood eosinophil counts &gt;\u20090.60\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L, presence of NPs, and \u2265\u20091 severe exacerbation of asthma in the last 12\u00a0months were shown to differentiate bronchiectasis in asthma-CRS patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Bronchiectasis commonly overlaps in asthma-CRS patients. The coexistence of bronchiectasis predicts a more severe disease subset in terms of asthma and CRS. We suggest that asthma-CRS patients with NPs, severe airflow obstruction, eosinophilic inflammation, and poor asthma control should receive HRCT for the early diagnosis of bronchiectasis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-021-01575-7","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T12:03:44Z","timestamp":1625486624000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence and clinical implications of bronchiectasis in patients with overlapping asthma and chronic rhinosinusitis: a single-center prospective study"],"prefix":"10.1186","volume":"21","author":[{"given":"Haiyan","family":"Sheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,5]]},"reference":[{"key":"1575_CR1","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1080\/03655230701624988","volume":"558","author":"HY Kim","year":"2007","unstructured":"Kim HY, So YK, Dhong HJ, Chung SK, Choi DC, Kwon NH, et al. 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Written informed consent was obtained from all recruited patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"211"}}