{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:32:20Z","timestamp":1787020340843,"version":"build-2736575974"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ciliated muconodular papillary tumor (CMPT) is an incredibly rare pulmonary tumor. Currently, little is known about CMPT, and it has not yet been classified by the World Health Organization. The clinical manifestation of CMPT is nonspecific and the diagnosis is only based on pathology. CMPT has been documented in limited reports as a benign tumor, thus the treatment is typically with surgical excision if a solid tumor is identifiable. The prognosis of CMPT is very positive, as no recurrence has been reported in the limited literature available. However, CMPT accompanied with adenocarcinoma in situ has not been reported previously in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>In this report, we presented a case of a 53-year-old male smoker with CMPT associated with adenocarcinoma in situ. This diagnosis was confirmed by pathological examination, including immunohistostaining. No solid resectable lesion was identified on CT scan; therefore, no surgery was performed. The patient\u2019s adenocarcinoma in situ was disseminated in both lungs, thus chemotherapeutic treatment with cisplatin and pemetrexed was given. The patient will be continually followed up closely on a wait-and-watch basis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In summary, our report reveals a unique case of CMPT in conjunction with adenocarcinoma in situ, potentially revealing an association between CMPT and malignancy which has not been previously reported. More similar case studies will be beneficial to determine the authentic relationship between CMPT and adenocarcinoma in situ.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12890-021-01581-9","type":"journal-article","created":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T23:10:35Z","timestamp":1626045035000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A rare case of ciliated muconodular papillary tumor accompanied with adenocarcinoma in situ"],"prefix":"10.1186","volume":"21","author":[{"given":"Lei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conner M.","family":"Willson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan T.","family":"Givens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Wakefield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanchun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9107-7374","authenticated-orcid":false,"given":"Yujiang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"1581_CR1","first-page":"964","volume":"20","author":"Y Ishikawa","year":"2002","unstructured":"Ishikawa Y. Ciliated muconodular papillary tumor of the peripheral lung: benign or malignant. Pathol Clin Med (Byouri-to-Rinsho). 2002;20:964\u20135.","journal-title":"Pathol Clin Med (Byouri-to-Rinsho)"},{"issue":"1","key":"1581_CR2","doi-asserted-by":"publisher","first-page":"135","DOI":"10.5858\/arpa.2017-0275-RS","volume":"143","author":"YW Lu","year":"2019","unstructured":"Lu YW, Yeh YC. Ciliated muconodular papillary tumors of the lung. Arch Pathol Lab Med. 2019;143(1):135\u20139.","journal-title":"Arch Pathol Lab Med"},{"issue":"1","key":"1581_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40792-019-0767-6","volume":"6","author":"K Murakami","year":"2020","unstructured":"Murakami K, Yutaka Y, Nakajima N, Yoshizawa A, Date H. Ciliated muconodular papillary tumor with a growing cavity shadow that mimicked colorectal metastasis to the lung: a case report. Surg Case Rep. 2020;6(1):1\u20135.","journal-title":"Surg Case Rep"},{"issue":"2","key":"1581_CR4","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4103\/JCRP.JCRP_32_19","volume":"7","author":"C-H Hsiao","year":"2020","unstructured":"Hsiao C-H, Liao J-H, Kwang W-K, Chen W-T. A rare case of contralateral ciliated muconodular papillary tumor after limited surgery. J Cancer Res Pract. 2020;7(2):82.","journal-title":"J Cancer Res Pract"},{"issue":"2","key":"1581_CR5","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3390\/medicina55020041","volume":"55","author":"HS Kim","year":"2019","unstructured":"Kim HS, Kim JH, Han B, Choi DR. Correlation of thyroid transcription factor-1 expression with EGFR mutations in non-small-cell lung cancer: a meta-analysis. Medicina. 2019;55(2):41.","journal-title":"Medicina"},{"key":"1581_CR6","doi-asserted-by":"crossref","unstructured":"Ishikawa M, Sumitomo S, Imamura N, Nishida T, Mineura K, Ono K. Ciliated muconodular papillary tumor of the lung: report of five cases. J Surg Case Rep. 2016; 216(8):rjw144.","DOI":"10.1093\/jscr\/rjw144"},{"issue":"1","key":"1581_CR7","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s13019-019-0962-3","volume":"14","author":"K Shao","year":"2019","unstructured":"Shao K, Wang Y, Xue Q, Mu J, Gao Y, Wang Y, Wang B, Zhou L, Gao S. Clinicopathological features and prognosis of ciliated muconodular papillary tumor. J Cardiothorac Surg. 2019;14(1):143.","journal-title":"J Cardiothorac Surg"},{"issue":"7","key":"1581_CR8","first-page":"1943","volume":"22","author":"Y Zhu","year":"2018","unstructured":"Zhu Y, Gan Y, Xu H, Chen W, Dai H. Clinical effectiveness of pemetrexed combined with cisplatin chemotherapy for advanced and maintenance treatment for patients with non-small-cell lung cancer. Eur Rev Med Pharmacol Sci. 2018;22(7):1943\u20137.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1581_CR9","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.humpath.2015.09.038","volume":"49","author":"KW Lau","year":"2016","unstructured":"Lau KW, Aubry MC, Tan GS, Lim CH, Takano AM. Ciliated muconodular papillary tumor: a solitary peripheral lung nodule in a teenage girl. Hum Pathol. 2016;49:22\u20136.","journal-title":"Hum Pathol"},{"issue":"8","key":"1581_CR10","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1097\/PAS.0000000000001086","volume":"42","author":"JC Chang","year":"2018","unstructured":"Chang JC, Montecalvo J, Borsu L, Lu S, Larsen BT, Wallace WD, Sae-Ow W, Mackinnon AC, Kim HR, Bowman A, et al. Bronchiolar adenoma: expansion of the concept of ciliated muconodular papillary tumors with proposal for revised terminology based on morphologic, immunophenotypic, and genomic analysis of 25 cases. Am J Surg Pathol. 2018;42(8):1010\u201326.","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"1581_CR11","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1111\/pin.12179","volume":"64","author":"HW Chuang","year":"2014","unstructured":"Chuang HW, Liao JB, Chang HC, Wang JS, Lin SL, Hsieh PP. Ciliated muconodular papillary tumor of the lung: a newly defined peripheral pulmonary tumor with conspicuous mucin pool mimicking colloid adenocarcinoma: a case report and review of literature. Pathol Int. 2014;64(7):352\u20137.","journal-title":"Pathol Int"},{"issue":"6","key":"1581_CR12","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1097\/PAS.0000000000000414","volume":"39","author":"T Kamata","year":"2015","unstructured":"Kamata T, Yoshida A, Kosuge T, Watanabe S-i, Asamura H, Tsuta K. Ciliated muconodular papillary tumors of the lung. Am J Surg Pathol. 2015;39(6):753\u201360.","journal-title":"Am J Surg Pathol"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-021-01581-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12890-021-01581-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-021-01581-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T13:45:11Z","timestamp":1672753511000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/s12890-021-01581-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,12]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1581"],"URL":"https:\/\/doi.org\/10.1186\/s12890-021-01581-9","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,12]]},"assertion":[{"value":"4 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The present study was approved by the 2nd People\u2019s Hospital of Hefei and Hefei Hospital Affiliated to Anhui Medical University Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for the publication of this case report and any accompanying images. The data presented in this case report do not allow identification of the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"223"}}