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CCAAT\/enhancer-binding protein \u03b2 (C-EBP\u03b2) could be induced by IL-17A and is up-regulated in COPD. We explored the effect of cigarettes and IL-17 on bronchial epithelial\u2013mesenchymal transition (EMT) in COPD mice and potential mechanism involved with C-EBP\u03b2 in this study.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>COPD model was established with mice by exposing to cigarettes. E-Cadherin, Vimentin, IL-17A and C-EBP\u03b2 distributions were detected in lung tissues. Primary bronchial epithelial cells were separated from health mice and cocultured with cigarette smoke extract (CSE) or\/and IL-17A. E-Cadherin, Vimentin and IL-17 receptor (IL-17R) expressions in vitro were assessed. When C-EBP\u03b2 were silenced by siRNA in cells, E-Cadherin, Vimentin and C-EBP\u03b2 expressions were detected.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>E-Cadherin distribution was less and Vimentin distribution was more in bronchus of COPD mice than controls. IL-17A and C-EBP\u03b2 expressions were higher in lung tissues of COPD mice than controls. In vitro, C-EBP\u03b2 protein expression was highest in CSE\u2009+\u2009IL-17A group, followed by CSE and IL-17A groups. E-cadherin expression in vitro was lowest and Vimentin expression was highest in CSE\u2009+\u2009IL-17A group, followed by CSE\u00a0or\u00a0IL-17A group. Those could be inhibited by C-EBP\u03b2 silenced.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>C-EBP\u03b2 mediates in cigarette\/IL-17A-induced bronchial EMT in COPD mice. Our findings contribute to a better understanding on the progress from COPD to lung cancers, which will provide novel avenues in preventing tumorigenesis of airway in the context of cigarette smoking.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-021-01738-6","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T17:07:44Z","timestamp":1637255264000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["C-EBP\u03b2 mediates in cigarette\/IL-17A-induced bronchial epithelial\u2013mesenchymal transition in COPD mice"],"prefix":"10.1186","volume":"21","author":[{"given":"Shuyuan","family":"Chu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"issue":"2","key":"1738_CR1","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.canlet.2016.09.002","volume":"382","author":"C Mouronte-Roib\u00e1s","year":"2016","unstructured":"Mouronte-Roib\u00e1s C, Leiro-Fern\u00e1ndez V, Fern\u00e1ndez-Villar A, Botana-Rial M, Ramos-Hern\u00e1ndez C, Ruano-Ravina A. 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