{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:03:25Z","timestamp":1776773005099,"version":"3.51.2"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Research Foundation of Lithuanian University of Health Sciences"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To evaluate cytokine profile, vitamin D status, symptom score and quality of life in patients with persistent allergic airway diseases sensitised to house dust mites (HDM) in comparison with healthy individuals.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material and methods<\/jats:title>\n                <jats:p>Patients sensitized to HDM with persistent AR and having symptoms for at least 2\u00a0years with or without AA were involved into the study. Measurements of vitamin D level in serum and IL-10, IL-13, IL-17, IL-22, IL-33 and IFN-gamma in serum and nasal lavage were performed by ELISA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Eighty-one subjects were involved into the study. Serum IL-10 concentration was higher in patients with AR than in patients with AR and AA (6.71\u2009\u00b1\u20091.73 vs. 1.98\u2009\u00b1\u20090.24, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). IFN-gamma level in nasal lavage was higher in patients with AR and AA than in patients with AR (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and healthy individuals (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) (7.50\u2009\u00b1\u20090.37 vs. 6.80\u2009\u00b1\u20090.99 vs. 6.50\u2009\u00b1\u20090.22). Serum IL-22 negatively correlated with IL-22 in nasal lavage, whereas serum IFN-gamma positively correlated with IFN-gamma in nasal lavage. Positive correlation between serum IL-17 and total IgE and negative correlation between IL-17 in nasal lavage and eosinophils in nasal smear were found in patients with AR and AA. Serum IFN-gamma decreased the risk of AR for healthy individuals. Serum IL-10 and vitamin D decreased risk for development of AA for patients with AR. IL-22 in serum and IL-10 and IL-33 in nasal lavage increased this risk.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Novel cytokines such as IL-22, IL-17 and IL-33 and vitamin D may be involved in pathogenesis of persistent airway inflammation in patients sensitized to HDM.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-021-01798-8","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T04:29:30Z","timestamp":1640060970000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Systemic and local cytokine profile and risk factors for persistent allergic airway inflammation in patients sensitised to house dust mite allergens"],"prefix":"10.1186","volume":"21","author":[{"given":"Laura","family":"Tamasauskiene","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigita","family":"Sitkauskiene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"issue":"3","key":"1798_CR1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jaci.2010.06.047","volume":"126","author":"JL Broek","year":"2010","unstructured":"Broek JL, Bousquet J, Baena-Cagnani CE, Bonini S, Canonica GW, Casale TB, et al. Allergic rhinitis and its impact on asthma (ARIA) guidelines: 2010 Revision. J Allergy Clin Immunol. 2010;126(3):466\u201376.","journal-title":"J Allergy Clin Immunol"},{"key":"1798_CR2","unstructured":"GINA. Global strategy for asthma management and prevention. 2020;"},{"issue":"1","key":"1798_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5415\/apallergy.2018.8.e7","volume":"8","author":"D Passali","year":"2018","unstructured":"Passali D, Cingi C, Staffa P, Passali F, Muluk NB, Bellussi ML. The international study of the allergic rhinitis survey\u202f: outcomes from 4 geographical regions. Asia Pac Allergy. 2018;8(1):1\u201315.","journal-title":"Asia Pac Allergy"},{"key":"1798_CR4","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/pai.12724","volume":"28","author":"M Valls-Mateus","year":"2017","unstructured":"Valls-Mateus M, Marino-Sanchez F, Ruiz-Echevarr\u00eda K, Cardenas-Escalante P, Jim\u00e9nez-Feijoo R, Blasco-Lozano J, et al. Nasal obstructive disorders impair health-related quality of life in adolescents with persistent allergic rhinitis: a real-life study. Pediatr Allergy Immunol. 2017;28:438\u201345.","journal-title":"Pediatr Allergy Immunol"},{"key":"1798_CR5","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1111\/j.1365-2222.2012.04025.x","volume":"42","author":"J Maspero","year":"2012","unstructured":"Maspero J, Lee BW, Katelaris CH, Potter PC, Cingi C, Lopatin A, et al. Quality of life and control of allergic rhinitis in patients from regions beyond western Europe and the United States. Clin Exp Allergy. 2012;42:1684\u201396.","journal-title":"Clin Exp Allergy"},{"key":"1798_CR6","unstructured":"Akdis CA, Hellings PW, Agache I. Global atlas of allergic rhinitis and chronic rhinosinusitis. Eur Acad Allergy Clin Immunol. 2015;1\u2013442."},{"key":"1798_CR7","unstructured":"Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention Updated 2020. Global Initiative for Asthma. 2021:1\u2013217."},{"issue":"11","key":"1798_CR8","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1111\/all.13200","volume":"72","author":"PW Hellings","year":"2017","unstructured":"Hellings PW, Klimek L, Cingi C, Agache I, Akdis C, Bachert C, et al. Non-allergic rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. Allergy Eur J Allergy Clin Immunol. 2017;72(11):1657\u201365.","journal-title":"Allergy Eur J Allergy Clin Immunol"},{"key":"1798_CR9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2147\/JAA.S81541","volume":"9","author":"P Giavina-Bianchi","year":"2016","unstructured":"Giavina-Bianchi P, Aun MV, Takejima P, Kalil J, Agondi RC. United airway disease: current perspectives. J Asthma Allergy. 2016;9:93\u2013100.","journal-title":"J Asthma Allergy"},{"key":"1798_CR10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fped.2017.00044","volume":"5","author":"A Licari","year":"2017","unstructured":"Licari A, Castagnoli R, Denicol\u00f2 CF, Rossini L, Marseglia A, Marseglia GL. The nose and the lung: united airway disease? Front Pediatr. 2017;5:44.","journal-title":"Front Pediatr"},{"key":"1798_CR11","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.chest.2017.09.005","volume":"153","author":"PE Pfeffer","year":"2018","unstructured":"Pfeffer PE, Hawrylowicz CM. Vitamin D in asthma: mechanisms of action and considerations for clinical trials. Chest. 2018;153:1229\u201339.","journal-title":"Chest"},{"key":"1798_CR12","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1183\/13993003.00234-2016","volume":"48","author":"E Vicente","year":"2016","unstructured":"Vicente E, Marin JM, Carrizo SJ, Osuna CS, Gonz\u00e1lez R, Marin-Oto M, et al. Upper airway and systemic inflammation in obstructive sleep apnoea. Eur Respir J. 2016;48:1108\u201317.","journal-title":"Eur Respir J"},{"key":"1798_CR13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/cea.13192","volume":"49","author":"P Campo","year":"2019","unstructured":"Campo P, Eguiluz-Gracia I, Bogas G, Salas M, Plaza Ser\u00f3n C, P\u00e9rez N, et al. Local allergic rhinitis: implications for management. Clin Exp Allergy. 2019;49:6\u201316.","journal-title":"Clin Exp Allergy"},{"issue":"3","key":"1798_CR14","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jaci.2014.11.001","volume":"135","author":"F Annunziato","year":"2015","unstructured":"Annunziato F, Romagnani C, Romagnani S. The 3 major types of innate and adaptive cell-mediated effector immunity. J Allergy Clin Immunol. 2015;135(3):626\u201335.","journal-title":"J Allergy Clin Immunol"},{"key":"1798_CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-065X.2008.00628.x","volume":"223","author":"LA Tesmer","year":"2008","unstructured":"Tesmer LA, Lundy SK, Sarkar S, Fox DA. Th17 cells in human disease. Immunol Rev. 2008;223:1\u201387.","journal-title":"Immunol Rev"},{"key":"1798_CR16","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1002\/eji.201242569","volume":"42","author":"CE Sutton","year":"2012","unstructured":"Sutton CE, Mielke LA, Mills KHG. IL-17-producing \u03b3\u03b4 T cells and innate lymphoid cells. Eur J Immunol. 2012;42:2221\u201331.","journal-title":"Eur J Immunol"},{"key":"1798_CR17","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.celrep.2017.07.063","volume":"20","author":"A De Luca","year":"2017","unstructured":"De Luca A, Pariano M, Cellini B, Costantini C, Villella VR, Jose SS, et al. The IL-17F\/IL-17RC axis promotes respiratory allergy in the proximal airways. Cell Rep. 2017;20:1667\u201380.","journal-title":"Cell Rep"},{"key":"1798_CR18","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/eji.201948409","volume":"50","author":"AC Jirmo","year":"2020","unstructured":"Jirmo AC, Busse M, Happle C, Skuljec J, Dal\u00fcge K, Habener A, et al. IL-17 regulates DC migration to the peribronchial LNs and allergen presentation in experimental allergic asthma. Eur J Immunol. 2020;50:1019\u201333.","journal-title":"Eur J Immunol"},{"key":"1798_CR19","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.rmed.2016.10.018","volume":"121","author":"JH Chen","year":"2016","unstructured":"Chen JH, Qin L, Shi YY, Feng JT, Zheng YL, Wan YF, et al. IL-17 protein levels in both induced sputum and plasma are increased in stable but not acute asthma individuals with obesity. Respir Med. 2016;121:48\u201358.","journal-title":"Respir Med"},{"key":"1798_CR20","doi-asserted-by":"crossref","first-page":"1900068","DOI":"10.1183\/13993003.00068-2019","volume":"54","author":"M Bullone","year":"2019","unstructured":"Bullone M, Carriero V, Bertolini F, Folino A, Mannelli A, Di SA, et al. Elevated serum IgE, oral corticosteroid dependence and IL-17\/22 expression in highly neutrophilic asthma. Eur Respir J. 2019;54:1900068.","journal-title":"Eur Respir J"},{"key":"1798_CR21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/ACI.0b013e32834eccaf","volume":"12","author":"J Bystrom","year":"2012","unstructured":"Bystrom J, Patel SY, Amin K, Bishop-Bailey D. Dissecting the role of eosinophil cationic protein in upper airway disease. Curr Opin Allergy Clin Immunol. 2012;12:18\u201323.","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"12","key":"1798_CR22","first-page":"3573","volume":"119","author":"S Eyerich","year":"2009","unstructured":"Eyerich S, Eyerich K, Pennino D, Carbone T, Nasorri F, Pallotta S, et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest. 2009;119(12):3573\u201385.","journal-title":"J Clin Invest"},{"issue":"1","key":"1798_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40629-015-0039-3","volume":"24","author":"K Eyerich","year":"2015","unstructured":"Eyerich K, Eyerich S. Th22 cells in allergic disease. Allergo J Int. 2015;24(1):1\u20137.","journal-title":"Allergo J Int"},{"issue":"1","key":"1798_CR24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00281-009-0188-x","volume":"32","author":"K Wolk","year":"2010","unstructured":"Wolk K, Witte E, Witte K, Warszawska K, Sabat R. Biology of interleukin-22. Semin Immunopathol. 2010;32(1):17\u201331.","journal-title":"Semin Immunopathol"},{"issue":"1","key":"1798_CR25","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.alit.2018.10.002","volume":"68","author":"T Ito","year":"2019","unstructured":"Ito T, Hirose K, Nakajima H. Bidirectional roles of IL-22 in the pathogenesis of allergic airway inflammation. Allergol Int. 2019;68(1):4\u20138.","journal-title":"Allergol Int"},{"issue":"4","key":"1798_CR26","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.pedneo.2017.11.020","volume":"59","author":"L Tamasauskiene","year":"2018","unstructured":"Tamasauskiene L, Sitkauskiene B. Role of Th22 and IL-22 in pathogenesis of allergic airway diseases: pro-inflammatory or anti-inflammatory effect? Pediatr Neonatol. 2018;59(4):339\u201344.","journal-title":"Pediatr Neonatol"},{"key":"1798_CR27","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1084\/jem.20162108","volume":"214","author":"T Ito","year":"2017","unstructured":"Ito T, Hirose K, Saku A, Kono K, Takatori H, Tamachi T, et al. IL-22 induces Reg3\u03b3 and inhibits allergic inflammation in house dust mite-induced asthma models. J Exp Med. 2017;214:3037\u201350.","journal-title":"J Exp Med"},{"key":"1798_CR28","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1172\/JCI124612","volume":"129","author":"LB Murrison","year":"2019","unstructured":"Murrison LB, Brandt EB, Myers JB, Khurana Hershey GK. Environmental exposures and mechanisms in allergy and asthma development. J Clin Investig. 2019;129:1504\u201315.","journal-title":"J Clin Investig"},{"key":"1798_CR29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/08830185.2016.1272600","volume":"36","author":"Z Aryan","year":"2017","unstructured":"Aryan Z, Rezaei N, Camargo CA. Vitamin D status, aeroallergen sensitization, and allergic rhinitis: a systematic review and meta-analysis. Int Rev Immunol. 2017;36:41\u201353.","journal-title":"Int Rev Immunol"},{"key":"1798_CR30","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1586\/1744666X.2016.1171143","volume":"12","author":"SK Quirk","year":"2016","unstructured":"Quirk SK, Rainwater E, Shure AK, Agrawal DK. Vitamin D in atopic dermatitis, chronic urticaria and allergic contact dermatitis. Expert Rev Clin Immunol. 2016;12:839\u201347.","journal-title":"Expert Rev Clin Immunol"},{"key":"1798_CR31","doi-asserted-by":"crossref","unstructured":"Liu J, Dong YQ, Yin J, Yao J, Shen J, Sheng GJ, et al. Meta-analysis of vitamin D and lung function in patients with asthma. Respir Res. 2019;20(1):161.","DOI":"10.1186\/s12931-019-1072-4"},{"key":"1798_CR32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.5415\/apallergy.2017.7.2.65","volume":"7","author":"H-Q Tian","year":"2017","unstructured":"Tian H-Q, Cheng L. The role of vitamin D in allergic rhinitis. Asia Pac Allergy. 2017;7:65.","journal-title":"Asia Pac Allergy"},{"key":"1798_CR33","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3109\/02770903.2016.1158267","volume":"53","author":"JC Han","year":"2016","unstructured":"Han JC, Du J, Zhang YJ, Qi GB, Li HB, Zhang YJ, et al. Vitamin D receptor polymorphisms may contribute to asthma risk. J Asthma. 2016;53:790\u2013800.","journal-title":"J Asthma"},{"key":"1798_CR34","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jaci.2014.10.012","volume":"136","author":"MA Calder\u00f3n","year":"2015","unstructured":"Calder\u00f3n MA, Linneberg A, Kleine-Tebbe J, De Blay F, De Rojas HFD, Virchow JC, et al. Respiratory allergy caused by house dust mites: what do we really know? J Allergy Clin Immunol. 2015;136:38\u201348.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"1798_CR35","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1398-9995.2003.00420.x","volume":"59","author":"SR Downie","year":"2004","unstructured":"Downie SR, Andersson M, Rimmer J, Leuppi JD, Xuan W, Akerlund A, et al. Symptoms of persistent allergic rhinitis during a full calendar year in house dust mite-sensitive subjects. Allergy Eur J Allergy Clin Immunol. 2004;59(4):406\u201314.","journal-title":"Allergy Eur J Allergy Clin Immunol"},{"issue":"2","key":"1798_CR36","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0091-6749(99)70380-5","volume":"104","author":"EF Juniper","year":"1999","unstructured":"Juniper EF, Thompson AK, Ferrie PJ, Roberts JN. Validation of the standardized version of the Rhinoconjunctivitis Quality of Life Questionnaire. J Allergy Clin Immunol. 1999;104(2):364\u20139.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"1798_CR37","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaci.2003.09.008","volume":"113","author":"RA Nathan","year":"2004","unstructured":"Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol. 2004;113(1):59\u201365.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"1798_CR38","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1183\/09031936.01.00088301","volume":"18","author":"EF Juniper","year":"2001","unstructured":"Juniper EF, Norman GR, Cox FM, Roberts JN. Comparison of the standard gamble, rating scale, AQLQ and SF-36 for measuring quality of life in asthma. Eur Respir J. 2001;18(1):38\u201344.","journal-title":"Eur Respir J"},{"issue":"2","key":"1798_CR39","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","volume":"28","author":"DJ Buysse","year":"1989","unstructured":"Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193\u2013213.","journal-title":"Psychiatry Res"},{"key":"1798_CR40","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/da.1033","volume":"13","author":"SM Katherine","year":"2001","unstructured":"Katherine SM, Bilt JV, Rucci P, Endicott J, Lydiard B, Otto MW, et al. Reliability and validity of a structured interview guide for the Hamilton anxiety rating scale (SIGH-A). Depress Anxiety. 2001;13:166\u201378.","journal-title":"Depress Anxiety"},{"key":"1798_CR41","doi-asserted-by":"crossref","unstructured":"Haahtela T, Selroos O, O\u2019Byrne PM. Revisiting early intervention in adult asthma. ERJ Open Res. 2015;1(1):00022\u20132015.","DOI":"10.1183\/23120541.00022-2015"},{"key":"1798_CR42","doi-asserted-by":"crossref","first-page":"929","DOI":"10.2147\/JAA.S316278","volume":"14","author":"HJ Song","year":"2021","unstructured":"Song HJ, Blake KV, Wilson DL, Winterstein AG, Park H. Health-related quality of life and health utilities of mild, moderate, and severe asthma: evidence from the medical expenditure panel survey. J Asthma Allergy. 2021;14:929\u201341.","journal-title":"J Asthma Allergy"},{"key":"1798_CR43","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1111\/j.1365-2222.2011.03935.x","volume":"42","author":"C Col\u00e1s","year":"2012","unstructured":"Col\u00e1s C, Galera H, A\u00f1ibarro B, Soler R, Navarro A, J\u00e1uregui I, et al. Disease severity impairs sleep quality in allergic rhinitis (The SOMNIAAR study). Clin Exp Allergy. 2012;42:1080\u20137.","journal-title":"Clin Exp Allergy"},{"key":"1798_CR44","doi-asserted-by":"crossref","first-page":"e0228533","DOI":"10.1371\/journal.pone.0228533","volume":"15","author":"J Liu","year":"2020","unstructured":"Liu J, Zhang X, Zhao Y, Wang Y. The association between allergic rhinitis and sleep: a systematic review and meta-analysis of observational studies. PLoS ONE. 2020;15:e0228533.","journal-title":"PLoS ONE"},{"key":"1798_CR45","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.jaci.2012.06.026","volume":"130","author":"D Koinis-Mitchell","year":"2012","unstructured":"Koinis-Mitchell D, Craig T, Esteban CA, Klein RB. Sleep and allergic disease: a summary of the literature and future directions for research. J Allergy Clin Immunol. 2012;130:1275\u201381.","journal-title":"J Allergy Clin Immunol"},{"key":"1798_CR46","doi-asserted-by":"crossref","unstructured":"Romano MR, James S, Farrington E, Perry R, Elliott L. The impact of perennial allergic rhinitis with\/without allergic asthma on sleep, work and activity level. Allergy, Asthma Clin Immunol. 2019;15:81.","DOI":"10.1186\/s13223-019-0391-9"},{"key":"1798_CR47","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.jaci.2020.08.041","volume":"147","author":"H He","year":"2021","unstructured":"He H, Del Duca E, Diaz A, Kim HJ, Gay-Mimbrera J, Zhang N, et al. Mild atopic dermatitis lacks systemic inflammation and shows reduced nonlesional skin abnormalities. J Allergy Clin Immunol. 2021;147:1369\u201380.","journal-title":"J Allergy Clin Immunol"},{"key":"1798_CR48","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/eji.201847883","volume":"49","author":"A Dolch","year":"2019","unstructured":"Dolch A, Kunz S, Dorn B, Alessandrini F, M\u00fcller W, Jack RS, et al. IL-10 signaling in dendritic cells is required for tolerance induction in a murine model of allergic airway inflammation. Eur J Immunol. 2019;49:302\u201312.","journal-title":"Eur J Immunol"},{"key":"1798_CR49","doi-asserted-by":"crossref","first-page":"e0161013","DOI":"10.1371\/journal.pone.0161013","volume":"11","author":"J Xu","year":"2016","unstructured":"Xu J, Han R, Kim DW, Mo JH, Jin Y, Rha KS, et al. Role of interleukin-10 on nasal polypogenesis in patients with chronic rhinosinusitis with nasal polyps. PLoS ONE. 2016;11:e0161013.","journal-title":"PLoS ONE"},{"key":"1798_CR50","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1615\/CritRevImmunol.v32.i1.30","volume":"32","author":"SS Iyer","year":"2012","unstructured":"Iyer SS, Cheng G. Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Crit Rev Immunol. 2012;32:23\u201363.","journal-title":"Crit Rev Immunol"},{"key":"1798_CR51","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3389\/fmed.2017.00139","volume":"4","author":"E Doran","year":"2017","unstructured":"Doran E, Cai F, Holweg CTJ, Wong K, Brumm J, Arron JR. Interleukin-13 in asthma and other eosinophilic disorders. Front Med. 2017;4:139.","journal-title":"Front Med"},{"issue":"1","key":"1798_CR52","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cyto.2015.05.014","volume":"75","author":"N Gour","year":"2015","unstructured":"Gour N, Wills-Karp M. IL-4 and IL-13 signaling in allergic airway disease. Cytokine. 2015;75(1):68\u201378.","journal-title":"Cytokine"},{"key":"1798_CR53","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.3389\/fphar.2019.01387","volume":"10","author":"G Marone","year":"2019","unstructured":"Marone G, Granata F, Pucino V, Pecoraro A, Heffler E, Loffredo S, et al. The intriguing role of interleukin 13 in the pathophysiology of asthma. Front Pharmacol. 2019;10:1387.","journal-title":"Front Pharmacol"},{"issue":"2","key":"1798_CR54","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000447692","volume":"170","author":"D Bagnasco","year":"2016","unstructured":"Bagnasco D, Ferrando M, Varricchi G, Passalacqua G, Canonica GW. A critical evaluation of anti-IL-13 and anti-IL-4 strategies in severe asthma. Int Arch Allergy Immunol. 2016;170(2):122\u201331.","journal-title":"Int Arch Allergy Immunol"},{"issue":"8","key":"1798_CR55","first-page":"925","volume":"15","author":"MC Matsunaga","year":"2016","unstructured":"Matsunaga MC, Yamauchi PS. IL-4 and IL-13 inhibition in atopic dermatitis. J Drugs Dermatol. 2016;15(8):925\u20139.","journal-title":"J Drugs Dermatol"},{"issue":"1","key":"1798_CR56","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2045-7022-2-13","volume":"2","author":"R Baumann","year":"2012","unstructured":"Baumann R, Rabaszowski M, Stenin I, Gaertner-Akerboom M, Scheckenbach K, Wiltfang J, et al. The release of IL-31 and IL-13 after nasal allergen challenge and their relation to nasal symptoms. Clin Transl Allergy. 2012;2(1):13.","journal-title":"Clin Transl Allergy"},{"issue":"2","key":"1798_CR57","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s10753-016-0503-3","volume":"40","author":"ML Alasandagutti","year":"2017","unstructured":"Alasandagutti ML, Ansari MSS, Sagurthi SR, Valluri V, Gaddam S. Role of IL-13 genetic variants in signalling of asthma. Inflammation. 2017;40(2):566\u201377.","journal-title":"Inflammation"},{"issue":"5","key":"1798_CR58","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.jaci.2004.08.032","volume":"114","author":"MA Berry","year":"2004","unstructured":"Berry MA, Parker D, Neale N, Woodman L, Morgan A, Monk P, et al. Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis. J Allergy Clin Immunol. 2004;114(5):1106\u20139.","journal-title":"J Allergy Clin Immunol"},{"issue":"8","key":"1798_CR59","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1053\/rmed.2000.0826","volume":"94","author":"J Prieto","year":"2000","unstructured":"Prieto J, Lensmar C, Roquet A, van der Ploeg I, Gigliotti D, Eklund A, et al. Increased interleukin-13 mRNA expression in bronchoalveolar lavage cells of atopic patients with mild asthma after repeated low-dose allergen provocations. Respir Med. 2000;94(8):806\u201314.","journal-title":"Respir Med"},{"issue":"4","key":"1798_CR60","doi-asserted-by":"crossref","first-page":"320","DOI":"10.5603\/ARM.a2020.0108","volume":"88","author":"N Makieieva","year":"2020","unstructured":"Makieieva N, Malakhova V, Vasylchenko Y, Tsymbal V. Are level of IL-13 and IL-4 predictive for formation of chronic inflammation in children with asthma? Adv Respir Med. 2020;88(4):320\u20136.","journal-title":"Adv Respir Med"},{"key":"1798_CR61","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.molimm.2018.11.015","volume":"105","author":"AN Kamali","year":"2019","unstructured":"Kamali AN, Noorbakhsh SM, Hamedifar H, Jadidi-Niaragh F, Yazdani R, Bautista JM, et al. A role for Th1-like Th17 cells in the pathogenesis of inflammatory and autoimmune disorders. Mol Immunol. 2019;105:107\u201315.","journal-title":"Mol Immunol"},{"key":"1798_CR62","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ajpath.2012.03.044","volume":"181","author":"MS Maddur","year":"2012","unstructured":"Maddur MS, Miossec P, Kaveri SV, Bayry J. Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies. Am J Pathol. 2012;181:8\u201318.","journal-title":"Am J Pathol"},{"key":"1798_CR63","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13601-017-0157-8","volume":"7","author":"G De Greve","year":"2017","unstructured":"De Greve G, Hellings PW, Fokkens WJ, Pugin B, Steelant B, Seys SF. Endotype-driven treatment in chronic upper airway diseases. Clin Transl Allergy. 2017;7:22.","journal-title":"Clin Transl Allergy"},{"key":"1798_CR64","doi-asserted-by":"crossref","unstructured":"Bae JS, Kim JH, Kim EH, Mo JH. The Role of IL-17 in a lipopolysaccharide-induced rhinitis model. Allergy, Asthma Immunol Res. 2017;9(2):169\u2013176.","DOI":"10.4168\/aair.2017.9.2.169"},{"key":"1798_CR65","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jaci.2016.10.034","volume":"140","author":"FLM Ricciardolo","year":"2017","unstructured":"Ricciardolo FLM, Sorbello V, Folino A, Gallo F, Massaglia GM, Favat\u00e0 G, et al. Identification of IL-17F\/frequent exacerbator endotype in asthma. J Allergy Clin Immunol. 2017;140:395\u2013406.","journal-title":"J Allergy Clin Immunol"},{"key":"1798_CR66","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1080\/02770903.2017.1283696","volume":"54","author":"R Halwani","year":"2017","unstructured":"Halwani R, Sultana A, Vazquez-Tello A, Jamhawi A, Al-Masri AA, Al-Muhsen S. Th-17 regulatory cytokines IL-21, IL-23, and IL-6 enhance neutrophil production of IL-17 cytokines during asthma. J Asthma. 2017;54:893\u2013904.","journal-title":"J Asthma"},{"key":"1798_CR67","doi-asserted-by":"publisher","DOI":"10.1186\/s12948-020-00117-6","author":"K Amin","year":"2020","unstructured":"Amin K, Issa SM, Ali KM, Aziz MI, Hama Amieen HM, Bystrom J, et al. Evidence for eosinophil and IL-17 mediated inflammation in allergic rhinitis. Clin Mol Allergy. 2020. https:\/\/doi.org\/10.1186\/s12948-020-00117-6.","journal-title":"Clin Mol Allergy"},{"key":"1798_CR68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/9131432","volume":"2018","author":"PB Degirmenci","year":"2018","unstructured":"Degirmenci PB, Aksun S, Altin Z, Bilgir F, Arslan IB, Colak H, et al. Allergic rhinitis and its relationship with IL-10, IL-17, TGF-\u03b2, IFN-\u03b3, IL 22, and IL-35. Dis Markers. 2018;2018:1\u20136.","journal-title":"Dis Markers"},{"key":"1798_CR69","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s00405-020-05811-4","volume":"277","author":"K Erkan","year":"2020","unstructured":"Erkan K, Bozkurt MK, Arta\u00e7 H, \u00d6zdemir H, \u00dcnl\u00fc A, Korucu EN, et al. The role of regulatory T cells in allergic rhinitis and their correlation with IL-10, IL-17 and neopterin levels in serum and nasal lavage fluid. Eur Arch Oto-Rhino-Laryngology. 2020;277:1109\u201314.","journal-title":"Eur Arch Oto-Rhino-Laryngology"},{"key":"1798_CR70","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18187-z","author":"W Lin","year":"2017","unstructured":"Lin W, Zhou Q, Liu C, Ying M, Xu S. Increased plasma IL-17, IL-31, and IL-33 levels in chronic spontaneous urticaria. Sci Rep. 2017. https:\/\/doi.org\/10.1038\/s41598-017-18187-z.","journal-title":"Sci Rep"},{"key":"1798_CR71","doi-asserted-by":"crossref","unstructured":"Morrow KN, Coopersmith CM, Ford ML. IL-17, IL-27, and IL-33: a novel axis linked to immunological dysfunction during sepsis. Front Immunol. 2019;10:1982.","DOI":"10.3389\/fimmu.2019.01982"},{"key":"1798_CR72","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.imbio.2015.02.005","volume":"220","author":"L Vocca","year":"2015","unstructured":"Vocca L, Di Sano C, Uasuf CG, Sala A, Riccobono L, Gangemi S, et al. IL-33\/ST2 axis controls Th2\/IL-31 and Th17 immune response in allergic airway diseases. Immunobiology. 2015;220:954\u201363.","journal-title":"Immunobiology"},{"issue":"9","key":"1798_CR73","doi-asserted-by":"crossref","first-page":"e107454","DOI":"10.1371\/journal.pone.0107454","volume":"9","author":"P Fang","year":"2014","unstructured":"Fang P, Zhou L, Zhou Y, Kolls JK, Zheng T, Zhu Z. Immune modulatory effects of IL-22 on allergen-induced pulmonary inflammation. PLoS ONE. 2014;9(9):e107454.","journal-title":"PLoS ONE"},{"issue":"7","key":"1798_CR74","doi-asserted-by":"crossref","first-page":"e21799","DOI":"10.1371\/journal.pone.0021799","volume":"6","author":"C Taube","year":"2011","unstructured":"Taube C, Tertilt C, Gy\u00fclveszi G, Dehzad N, Kreymborg K, Schneeweiss K, et al. IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease. PLoS ONE. 2011;6(7):e21799.","journal-title":"PLoS ONE"},{"key":"1798_CR75","doi-asserted-by":"crossref","unstructured":"Hakemi M, Eskandari N, Yazdani R, Farahani R, Sherkat R. Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma. Adv Biomed Res. 2014;3:127.","DOI":"10.4103\/2277-9175.133249"},{"issue":"9","key":"1798_CR76","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1164\/rccm.201008-1383OC","volume":"183","author":"A-G Besnard","year":"2011","unstructured":"Besnard A-G, Sabat R, Dumoutier L, Renauld J-C, Willart M, Lambrecht B, et al. Dual role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A. Am J Respir Crit Care Med. 2011;183(9):1153\u201363.","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"1798_CR77","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.amjoto.2018.12.009","volume":"40","author":"S Shahsavan","year":"2019","unstructured":"Shahsavan S, Pirayesh A, Samani OZ, Shirzad H, Zamani MA, Amani S, et al. The relationship between IL-17A and IL-22 expression and clinical severity in patients with moderate\/severe persistent allergic rhinitis. Am J Otolaryngol Head Neck Med Surg. 2019;40(2):173\u20138. https:\/\/doi.org\/10.1016\/j.amjoto.2018.12.009.","journal-title":"Am J Otolaryngol Head Neck Med Surg"},{"issue":"4","key":"1798_CR78","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000250438","volume":"151","author":"Y Zhao","year":"2010","unstructured":"Zhao Y, Yang J, Gao YD, Guo W. Th17 immunity in patients with allergic asthma. Int Arch Allergy Immunol. 2010;151(4):297\u2013307.","journal-title":"Int Arch Allergy Immunol"},{"issue":"10","key":"1798_CR79","doi-asserted-by":"crossref","first-page":"5077","DOI":"10.4049\/jimmunol.1001560","volume":"187","author":"K Nakagome","year":"2011","unstructured":"Nakagome K, Imamura M, Kawahata K, Harada H, Okunishi K, Matsumoto T, et al. High expression of IL-22 suppresses antigen-induced immune responses and eosinophilic airway inflammation via an IL-10-associated mechanism. J Immunol. 2011;187(10):5077\u201389.","journal-title":"J Immunol"},{"key":"1798_CR80","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-114","author":"B Bosnjak","year":"2011","unstructured":"Bosnjak B, Stelzmueller B, Erb KJ, Epstein MM. Treatment of allergic asthma: modulation of Th2 cells and their responses. Respir Res. 2011. https:\/\/doi.org\/10.1186\/1465-9921-12-114.","journal-title":"Respir Res"},{"key":"1798_CR81","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jaci.2019.08.006","volume":"145","author":"WJ Branchett","year":"2020","unstructured":"Branchett WJ, St\u00f6lting H, Oliver RA, Walker SA, Puttur F, Gregory LG, et al. A T cell\u2013myeloid IL-10 axis regulates pathogenic IFN-\u03b3\u2013dependent immunity in a mouse model of type 2\u2013low asthma. J Allergy Clin Immunol. 2020;145:666-678.e9.","journal-title":"J Allergy Clin Immunol"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-021-01798-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12890-021-01798-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-021-01798-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T04:32:24Z","timestamp":1640061144000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/s12890-021-01798-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":81,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1798"],"URL":"https:\/\/doi.org\/10.1186\/s12890-021-01798-8","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"6 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Kaunas Regional Biomedical Research Ethics Committee (No. BE-2-28). Subjects gave their written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"424"}}