{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:44:30Z","timestamp":1793663070744,"version":"4.5.1"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Chongqing Clinical Research Centre of Imaging and Nuclear Medicine, China","award":["CSTC2015YFPT-gcjsyjzx0175"],"award-info":[{"award-number":["CSTC2015YFPT-gcjsyjzx0175"]}]},{"name":"Chongqing 2019 Science and Technology Joint Medical Research Project","award":["2019ZDXM049"],"award-info":[{"award-number":["2019ZDXM049"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Noncardiogenic pulmonary edema (NCPE) is a rare and life-threatening allergy-like reaction to the intravascular injection of a nonionic radiographic agent. We first describe a very rare case of fatal NCPE after the intravenous injection of nonionic, iso-osmolar iodine contrast media.<\/jats:p>\n                <jats:p>Case presentation<\/jats:p>\n                <jats:p>A 55-year-old male patient was admitted to the hospital with esophageal cancer. After the intravenous administration of 100\u00a0mL iodixanol, the patient first exhibited digestive tract symptoms, including abdominal pain, diarrhea, and vomiting, with no dyspnea, rash, itching, or throat edema. He received anti-allergy treatment, but his symptoms did not improve; instead, he further developed pulmonary edema. Arterial blood gas analysis results were as follows: pH, 7.08; PO<jats:sub>2<\/jats:sub>, 70\u00a0mm Hg; PCO<jats:sub>2<\/jats:sub>, 40\u00a0mm Hg; and SaO<jats:sub>2<\/jats:sub>, 52%. Then, the patient received emergent tracheal intubation and ventilation to assist breathing, and he was transferred to the intensive care unit (ICU) for further treatment. In the ICU, the patient developed shock and respiratory and circulatory failure; therefore, he received shock resuscitation, acidosis correction, muscle relaxants to lower the work of breathing, and cardiotonic therapy. The patient eventually died. During the ICU period, emergency bedside color ultrasound showed a diffuse B line in both lungs, and the size of the cardiac cavity was normal, but the ventricular rate was extremely fast. Chest radiography showed pulmonary edema with a normal cardiac silhouette, and the brain natriuretic peptide (BNP) level was in the normal range.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>NCPE is a rare and critical allergy-like reaction to the use of a nonionic iso-osmolar radiocontrast contrast medium. Clinicians should pay very close attention to digestive tract manifestations during the medical observation of patients, as gastrointestinal manifestations may be the prodromal symptoms of NCPE caused by iso-osmolar contrast medium injection.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-022-01908-0","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T13:21:48Z","timestamp":1648732908000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fatal noncardiogenic pulmonary edema related to nonionic, iso-osmolar iodine contrast medium: one case report"],"prefix":"10.1186","volume":"22","author":[{"given":"Kun-ming","family":"Yi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3591-3451","authenticated-orcid":false,"given":"Xue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"issue":"5","key":"1908_CR1","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3109\/02841859609177723","volume":"37","author":"A Hauggaard","year":"1996","unstructured":"Hauggaard A. Non-cardiogenic pulmonary oedema after intravenous administration of non-ionic contrast media. Acta Radiol. 1996;37(5):823\u20135.","journal-title":"Acta Radiol"},{"issue":"9311","key":"1908_CR2","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/S0140-6736(02)08068-6","volume":"359","author":"RE Paul","year":"2002","unstructured":"Paul RE, George G. Fatal non-cardiogenic pulmonary oedema after intravenous non-ionic radiographic contrast. Lancet. 2002;359(9311):1037\u20138.","journal-title":"Lancet"},{"key":"1908_CR3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.2147\/OAEM.S154081","volume":"10","author":"L Pincet","year":"2018","unstructured":"Pincet L, Lecca G. Acute pulmonary edema induced by non-ionic low-osmolar radiographic contrast media. 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Mayo Clin Proc. 2016;91(3):362\u20136.","journal-title":"Mayo Clin Proc"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-022-01908-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12890-022-01908-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-022-01908-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T13:22:40Z","timestamp":1648732960000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/s12890-022-01908-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,31]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["1908"],"URL":"https:\/\/doi.org\/10.1186\/s12890-022-01908-0","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,31]]},"assertion":[{"value":"17 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the ethics committee of the Daping Hospital of Army Medical University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written and signed informed consent was obtained from the patient's son to publish the case report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"118"}}