{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:30:29Z","timestamp":1790317829825,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Consulting Research Project of Chinese Academy of Engineering","award":["2019-XZ-70"],"award-info":[{"award-number":["2019-XZ-70"]}]},{"name":"Consulting Research Project of Chinese Academy of Engineering","award":["2019-XZ-70"],"award-info":[{"award-number":["2019-XZ-70"]}]},{"name":"Consulting Research Project of Chinese Academy of Engineering","award":["2019-XZ-70"],"award-info":[{"award-number":["2019-XZ-70"]}]},{"name":"Consulting Research Project of Chinese Academy of Engineering","award":["2019-XZ-70"],"award-info":[{"award-number":["2019-XZ-70"]}]},{"name":"Consulting Research Project of Chinese Academy of Engineering","award":["2019-XZ-70"],"award-info":[{"award-number":["2019-XZ-70"]}]},{"name":"Consulting Research Project of Chinese Academy of Engineering","award":["2019-XZ-70"],"award-info":[{"award-number":["2019-XZ-70"]}]},{"name":"Consulting Research Project of Chinese Academy of Engineering","award":["2021-JJZD-10"],"award-info":[{"award-number":["2021-JJZD-10"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Asbestosis and fibrotic hypersensitivity pneumonitis (FHP) share the pathogenetic mechanisms induced bronchiolocentric fibrotic process secondary to inhalation exposure. Under the occupational and environmental mixed exposures, asbestosis and FHP are needed to make the differential diagnoses on high-resolution computed tomography (HRCT), especially in the countries still using asbestos. The study aimed to analyze the HRCT features of asbestosis versus FHP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The patients with asbestosis or with HP were sequentially recruited in this comparative study at Beijing Chaoyang Hospital between January 2006 and December 2016. Patients\u2019 clinical data were obtained from a predesigned charts. The international classification of HRCT for occupational and environmental respiratory diseases was used to categorize chest imaging findings in patients. The calculation of test statistics was used to compare the imaging features of asbestosis and FHP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>341 patients with asbestosis and 158 patients with HP were sequentially recruited, among which 204 patients with asbestosis and 74 patients with FHP were eligible for data analysis. Patients with asbestosis were older and had a longer latent period until disease manifestation than those with FHP. Asbestosis was characterized by irregular and\/or linear opacities, with lower lung preponderance, accompanied by ground-glass opacities and mosaic attenuation. Notably, 98.5% of patients with asbestosis showed benign pleural abnormalities, and 39.7% of these patients had diffuse pleural thickening with parenchymal bands and\/or rounded atelectasis. Abnormalities of the mediastinal and diaphragmatic pleura were observed only in cases of asbestosis, and this finding showed high specificity for the diagnosis for asbestosis compared with that for FHP. Subpleural dots or diaphragmatic pleural abnormalities showed moderate sensitivity and high specificity for diagnosis of asbestosis compared with that for FHP. Interobserver reliability was good for evaluation of imaging findings including honeycombing, pleural calcification, lymphadenectasis, and lymph node calcification.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>HRCT-based imaging findings can distinguish between asbestosis and FHP to a certain extent, particularly with regard to subpleural dots and diaphragmatic pleural abnormalities that characterize the former.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-022-01967-3","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T05:03:58Z","timestamp":1653455038000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["High-resolution computed tomography features of asbestosis versus fibrotic hypersensitivity pneumonitis: an observational study"],"prefix":"10.1186","volume":"22","author":[{"given":"Ruimin","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"issue":"2","key":"1967_CR1","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1179\/2049396714Y.0000000105","volume":"21","author":"X Baur","year":"2015","unstructured":"Baur X, Soskolne CL, Lemen RA, Schneider J, Woitowitz HJ, Budnik LT. How conflicted authors undermine the World Health Organization (WHO) campaign to stop all use of asbestos: spotlight on studies showing that chrysotile is carcinogenic and facilitates other non-cancer asbestos-related diseases. Int J Occup Environ Health. 2015;21(2):176\u20139. https:\/\/doi.org\/10.1179\/2049396714Y.0000000105.","journal-title":"Int J Occup Environ Health"},{"issue":"4","key":"1967_CR2","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1111\/crj.12728","volume":"12","author":"X Yang","year":"2018","unstructured":"Yang X, Yan Y, Xue C, Du X, Ye Q. Association between increased small airway obstruction and asbestos exposure in patients with asbestosis. Clin Respir J. 2018;12(4):1676\u201384. https:\/\/doi.org\/10.1111\/crj.12728.","journal-title":"Clin Respir J"},{"key":"1967_CR3","doi-asserted-by":"publisher","unstructured":"Diagnosis and initial management of nonmalignant diseases related to asbestos. Am J Respir Crit Care Med. 2004; 170(6):691\u2013715. https:\/\/doi.org\/10.1164\/rccm.200310-1436ST.","DOI":"10.1164\/rccm.200310-1436ST"},{"issue":"3","key":"1967_CR4","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1148\/radiol.2293020668","volume":"229","author":"SJ Copley","year":"2003","unstructured":"Copley SJ, Wells AU, Sivakumaran P, et al. Asbestosis and idiopathic pulmonary fibrosis: comparison of thin-section CT features. Radiology. 2003;229(3):731\u20136. https:\/\/doi.org\/10.1148\/radiol.2293020668.","journal-title":"Radiology"},{"issue":"5","key":"1967_CR5","doi-asserted-by":"publisher","first-page":"e44","DOI":"10.1164\/rccm.201807-1255ST","volume":"198","author":"G Raghu","year":"2018","unstructured":"Raghu G, Remy-Jardin M, Myers JL, et al. Diagnosis of idiopathic pulmonary fibrosis. An official ATS\/ERS\/JRS\/ALAT clinical practice guideline. Am J Respir Crit Care Med. 2018;198(5):e44\u201368. https:\/\/doi.org\/10.1164\/rccm.201807-1255ST.","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"1967_CR6","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.iac.2012.08.008","volume":"32","author":"S Ohshimo","year":"2012","unstructured":"Ohshimo S, Bonella F, Guzman J, Costabel U. Hypersensitivity pneumonitis. Immunol Allergy Clin North Am. 2012;32(4):537\u201356. https:\/\/doi.org\/10.1016\/j.iac.2012.08.008.","journal-title":"Immunol Allergy Clin North Am"},{"issue":"3","key":"1967_CR7","doi-asserted-by":"publisher","first-page":"e36","DOI":"10.1164\/rccm.202005-2032ST","volume":"202","author":"G Raghu","year":"2020","unstructured":"Raghu G, Remy-Jardin M, Ryerson CJ, et al. Diagnosis of hypersensitivity pneumonitis in adults. An official ATS\/JRS\/ALAT clinical practice guideline. Am J Respir Crit Care Med. 2020;202(3):e36\u201369. https:\/\/doi.org\/10.1164\/rccm.202005-2032ST.","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"1967_CR8","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1016\/j.ijsu.2014.07.013","volume":"12","author":"E von Elm","year":"2014","unstructured":"von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Int J Surg. 2014;12(12):1495\u20139. https:\/\/doi.org\/10.1016\/j.ijsu.2014.07.013.","journal-title":"Int J Surg"},{"key":"1967_CR9","unstructured":"Fedotov FI. Guidelines for the use of the ILO international classification of radiographs of pneumoconioses, revised edition 2011. 2011."},{"issue":"6","key":"1967_CR10","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1164\/rccm.201611-2201PP","volume":"196","author":"M Vasakova","year":"2017","unstructured":"Vasakova M, Morell F, Walsh S, Leslie K, Raghu G. Hypersensitivity pneumonitis: perspectives in diagnosis and management. Am J Respir Crit Care Med. 2017;196(6):680\u20139. https:\/\/doi.org\/10.1164\/rccm.201611-2201PP.","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"1967_CR11","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1539\/joh.l8030","volume":"51","author":"N Suganuma","year":"2009","unstructured":"Suganuma N, Kusaka Y, Hering KG, et al. Reliability of the proposed international classification of high-resolution computed tomography for occupational and environmental respiratory diseases. J Occup Health. 2009;51(3):210\u201322. https:\/\/doi.org\/10.1539\/joh.l8030.","journal-title":"J Occup Health"},{"issue":"6","key":"1967_CR12","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1164\/rccm.201308-1483ST","volume":"188","author":"WD Travis","year":"2013","unstructured":"Travis WD, Costabel U, Hansell DM, et al. An official American thoracic society\/European respiratory society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med. 2013;188(6):733\u201348. https:\/\/doi.org\/10.1164\/rccm.201308-1483ST.","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"1967_CR13","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1183\/09031936.05.00034805","volume":"26","author":"MR Miller","year":"2005","unstructured":"Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J. 2005;26(2):319\u201338. https:\/\/doi.org\/10.1183\/09031936.05.00034805.","journal-title":"Eur Respir J"},{"issue":"8","key":"1967_CR14","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/0895-4356(91)90128-v","volume":"44","author":"DL Simel","year":"1991","unstructured":"Simel DL, Samsa GP, Matchar DB. Likelihood ratios with confidence: sample size estimation for diagnostic test studies. J Clin Epidemiol. 1991;44(8):763\u201370. https:\/\/doi.org\/10.1016\/0895-4356(91)90128-v.","journal-title":"J Clin Epidemiol"},{"issue":"6840","key":"1967_CR15","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1136\/bmj.304.6840.1491","volume":"304","author":"P Brennan","year":"1992","unstructured":"Brennan P, Silman A. Statistical methods for assessing observer variability in clinical measures. BMJ. 1992;304(6840):1491\u20134. https:\/\/doi.org\/10.1136\/bmj.304.6840.1491.","journal-title":"BMJ"},{"issue":"4","key":"1967_CR16","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1378\/chest.95.4.831","volume":"95","author":"RF Sison","year":"1989","unstructured":"Sison RF, Hruban RH, Moore GW, Kuhlman JE, Wheeler PS, Hutchins GM. Pulmonary Disease associated with pleural \u201casbestos\u201d plaques. Chest. 1989;95(4):831\u20135. https:\/\/doi.org\/10.1378\/chest.95.4.831.","journal-title":"Chest"},{"issue":"5","key":"1967_CR17","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1183\/09031936.98.11051021","volume":"11","author":"PA Gevenois","year":"1998","unstructured":"Gevenois PA, de Maertelaer V, Madani A, Winant C, Sergent G, De Vuyst P. Asbestosis, pleural plaques and diffuse pleural thickening: three distinct benign responses to asbestos exposure. Eur Respir J. 1998;11(5):1021\u20137. https:\/\/doi.org\/10.1183\/09031936.98.11051021.","journal-title":"Eur Respir J"},{"issue":"1","key":"1967_CR18","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1148\/radiol.2453061881","volume":"246","author":"CI Silva","year":"2008","unstructured":"Silva CI, Muller NL, Lynch DA, Curran-Everett D, Brown KK, Lee KS, Chung MP, Churg A. Chronic hypersensitivity pneumonitis: differentiation from idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia by using thin-section CT. Radiology. 2008;246(1):288\u201397. https:\/\/doi.org\/10.1148\/radiol.2453061881.","journal-title":"Radiology"},{"issue":"1","key":"1967_CR19","doi-asserted-by":"publisher","first-page":"163","DOI":"10.2214\/ajr.181.1.1810163","volume":"181","author":"M Akira","year":"2003","unstructured":"Akira M, Yamamoto S, Inoue Y, Sakatani M. High-resolution CT of asbestosis and idiopathic pulmonary fibrosis. AJR Am J Roentgenol. 2003;181(1):163\u20139. https:\/\/doi.org\/10.2214\/ajr.181.1.1810163.","journal-title":"AJR Am J Roentgenol"},{"issue":"4","key":"1967_CR20","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/ajim.22573","volume":"59","author":"M Akira","year":"2016","unstructured":"Akira M, Morinaga K. The comparison of high-resolution computed tomography findings in asbestosis and idiopathic pulmonary fibrosis. Am J Ind Med. 2016;59(4):301\u20136. https:\/\/doi.org\/10.1002\/ajim.22573.","journal-title":"Am J Ind Med"},{"issue":"2","key":"1967_CR21","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1148\/radiology.178.2.1987601","volume":"178","author":"M Akira","year":"1991","unstructured":"Akira M, Yokoyama K, Yamamoto S, Higashihara T, Morinaga K, Kita N, Morimoto S, Ikezoe J, Kozuka T. Early asbestosis: evaluation with high-resolution CT. Radiology. 1991;178(2):409\u201316. https:\/\/doi.org\/10.1148\/radiology.178.2.1987601.","journal-title":"Radiology"},{"issue":"3","key":"1967_CR22","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1148\/radiology.158.3.3945733","volume":"158","author":"H Yoshimura","year":"1986","unstructured":"Yoshimura H, Hatakeyama M, Otsuji H, et al. Pulmonary asbestosis: CT study of subpleural curvilinear shadow. Work Prog Radiol. 1986;158(3):653\u20138. https:\/\/doi.org\/10.1148\/radiology.158.3.3945733.","journal-title":"Work Prog Radiol"},{"key":"1967_CR23","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00531-2019","author":"J Barnett","year":"2019","unstructured":"Barnett J, Molyneaux PL, Rawal B, et al. Variable utility of mosaic attenuation to distinguish fibrotic hypersensitivity pneumonitis from idiopathic pulmonary fibrosis. Eur Respir J. 2019. https:\/\/doi.org\/10.1183\/13993003.00531-2019.","journal-title":"Eur Respir J"},{"issue":"9","key":"1967_CR24","doi-asserted-by":"publisher","first-page":"e38874","DOI":"10.1136\/bmjopen-2020-038874","volume":"10","author":"Y Fan","year":"2020","unstructured":"Fan Y, Xu W, Wang Y, Wang Y, Yu S, Ye Q. Association of occupational dust exposure with combined chronic obstructive pulmonary disease and pneumoconiosis: a cross-sectional study in China. BMJ Open. 2020;10(9):e38874. https:\/\/doi.org\/10.1136\/bmjopen-2020-038874.","journal-title":"BMJ Open"},{"issue":"8","key":"1967_CR25","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1164\/rccm.201710-1986OC","volume":"197","author":"J Morisset","year":"2018","unstructured":"Morisset J, Johannson KA, Jones KD, Wolters PJ, Collard HR, Walsh S, Ley B. Identification of diagnostic criteria for chronic hypersensitivity pneumonitis: an international modified Delphi survey. Am J Respir Crit Care Med. 2018;197(8):1036\u201344. https:\/\/doi.org\/10.1164\/rccm.201710-1986OC.","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"1967_CR26","doi-asserted-by":"publisher","first-page":"899","DOI":"10.3390\/ijerph8030899","volume":"8","author":"T Kishimoto","year":"2011","unstructured":"Kishimoto T, Kato K, Arakawa H, Ashizawa K, Inai K, Takeshima Y. Clinical, radiological, and pathological investigation of asbestosis. Int J Environ Res Public Health. 2011;8(3):899\u2013912. https:\/\/doi.org\/10.3390\/ijerph8030899.","journal-title":"Int J Environ Res Public Health"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-022-01967-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12890-022-01967-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-022-01967-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T05:04:20Z","timestamp":1653455060000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/s12890-022-01967-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,25]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["1967"],"URL":"https:\/\/doi.org\/10.1186\/s12890-022-01967-3","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,25]]},"assertion":[{"value":"11 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All investigations were conducted in accordance with the ethical standards of Beijing Chao-Yang Hospital and the World Medical Association Declaration of Helsinki. The study was approved by the Institutional Review Board of Beijing Chao-Yang Hospital with approval number 2018- KE-289. Written informed consent was obtained from all individuals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"207"}}