{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T20:46:50Z","timestamp":1793479610531,"version":"4.5.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Chen Xiao-ping Foundation for the Development of Science and Technology of Hubei Province","award":["No. CXPJJH11900018-05"],"award-info":[{"award-number":["No. CXPJJH11900018-05"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Lung ischemia\u2013reperfusion injury (LIRI) is a cause of poor prognosis in several lung diseases and after lung transplantation. In LIRI, matrix metalloproteinases and pyroptosis indicators change in parallel, both of them involvement of inflammatory modulation, but it is unclear whether they are related to each other.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We analyzed the matrix metalloproteinases (MMPs) changes from RNA sequencing (RNA-Seq) data of human transplantation and rat ischemia\u2013reperfusion lung tissues in the Group on Earth Observations (GEO) database. Then established the mouse LIRI model to validate the changes. Further, the severity of lung injury was measured after intervening the matrix metalloproteinases changes with their selective inhibitor during Lung ischemia\u2013reperfusion. Meanwhile, lung, pyroptosis was assessed by assaying the activity of Caspase-1 and interleukin 1\u03b2 (IL-1\u03b2) before and after intervening the matrix metalloproteinases changes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The RNA-Seq data revealed that matrix metallopeptidase 2 (MMP2), matrix metallopeptidase 9 (MMP9) mRNA expression was elevated both in human lung transplantation and rat lung ischemia\u2013reperfusion tissues, consistent with the change in our mouse model. At the same time, the activity of Caspase-1 and IL-1\u03b2 were increased after LIRI. While, the lung injury was attenuated for the use of MMP2 and MMP9 selective inhibitor SB-3CT. Likewise, lung pyroptosis alleviated when treatment the mice with SB-3CT in LIRI.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We conclude that MMP2 and MMP9 are involved in the process of LIRI, the mechanism of which is related to the promotion of lung pyroptosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-022-02018-7","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T14:03:16Z","timestamp":1655301796000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["MMP2 and MMP9 contribute to lung ischemia\u2013reperfusion injury via promoting pyroptosis in mice"],"prefix":"10.1186","volume":"22","author":[{"given":"Peng","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-Cheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Kun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Song","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"2018_CR1","first-page":"401","volume":"3","author":"A Sharma","year":"2012","unstructured":"Sharma A, Stone M, Lau C, et al. Pulmonary transplantation and ischemia-reperfusion injury. Top Thoracic Surg. 2012;3:401.","journal-title":"Top Thoracic Surg"},{"key":"2018_CR2","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1378\/chest.121.4.1269","volume":"121","author":"C Ng","year":"2002","unstructured":"Ng C, Wan S, Yim A, et al. Pulmonary dysfunction after cardiac surgery. Chest J. 2002;121:1269\u2013312.","journal-title":"Chest J"},{"key":"2018_CR3","doi-asserted-by":"publisher","first-page":"e79","DOI":"10.1016\/j.jss.2012.11.014","volume":"182","author":"J Zhang","year":"2013","unstructured":"Zhang J, Wang J, Zheng Z, et al. Participation of autophagy in lung ischemia-reperfusion injury in vivo. J Surg Res. 2013;182:e79-87.","journal-title":"J Surg Res"},{"key":"2018_CR4","first-page":"201","volume":"2","author":"A Shimamoto","year":"2006","unstructured":"Shimamoto A, Pohlman T, Shomura S, et al. Toll-like receptor 4 mediates lung ischemia-reperfusion injury. Ann Thorac Surg. 2006;2:201\u20132023.","journal-title":"Ann Thorac Surg"},{"key":"2018_CR5","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1183\/09031936.05.00030304","volume":"25","author":"C Ng","year":"2005","unstructured":"Ng C, Wan S, Yim A. Pulmonary ischemia-reperfusion injury: role of apoptosis. Eur Respir J. 2005;25:356\u201363.","journal-title":"Eur Respir J"},{"key":"2018_CR6","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s00595-005-3124-2","volume":"36","author":"C Ng","year":"2006","unstructured":"Ng C, Wan S, Arifi A, et al. inflammatory response to pulmonary ischemia-reperfusion injury. Surg Today. 2006;36:205\u201314.","journal-title":"Surg Today"},{"key":"2018_CR7","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00134-006-0096-7","volume":"32","author":"S Cottini","year":"2006","unstructured":"Cottini S, Lerch N, De P, et al. risk factors for reperfusion injury after lung transplantation. Intensive Care Med. 2006;32:55\u2013563.","journal-title":"Intensive Care Med"},{"key":"2018_CR8","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0003-4975(00)01425-9","volume":"69","author":"R King","year":"2000","unstructured":"King R, Binns O, Rodriguez F, et al. reperfusion injury significantly impacts clinical outcome after pulmonary transplantation. Ann Thorac Surg. 2000;69:161\u20135.","journal-title":"Ann Thorac Surg"},{"issue":"2","key":"2018_CR9","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrmicro2070","volume":"7","author":"T Bergsbaken","year":"2009","unstructured":"Bergsbaken T, Fink S, Cookson B. Pyroptosis: host cell death and inflammation. Nat Rev Microbiol. 2009;7(2):99\u2013109.","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"2018_CR10","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","volume":"42","author":"J Shi","year":"2017","unstructured":"Shi J, Gao W, Shao F. Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci. 2017;42(4):245\u201354.","journal-title":"Trends Biochem Sci"},{"key":"2018_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119402","volume":"276","author":"P Zhou","year":"2021","unstructured":"Zhou P, Guo H, Li Y, Liu Q, Qiao X, Lu Y, Mei PY, Zheng Z, Li J. Monocytes promote pyroptosis of endothelial cells during lung ischemia-reperfusion via IL-1R\/NF-\u03baB\/NLRP3 signaling. Life Sci. 2021;276: 119402.","journal-title":"Life Sci"},{"issue":"7","key":"2018_CR12","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/j.cell.2016.11.047","volume":"167","author":"J Yuan","year":"2016","unstructured":"Yuan J, Najafov A, Py B. Roles of Caspases in Necrotic Cell Death. Cell. 2016;167(7):1693\u2013704.","journal-title":"Cell"},{"key":"2018_CR13","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/imr.12534","volume":"277","author":"SM Man","year":"2017","unstructured":"Man SM, Karki R, Kanneganti TD. Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunol Rev. 2017;277:61\u201375.","journal-title":"Immunol Rev"},{"key":"2018_CR14","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/bpa.12476","volume":"27","author":"J Barrington","year":"2017","unstructured":"Barrington J, Lemarchand E, Allan SM. A brain in flame; do inflammasomes and pyroptosis influence stroke pathology? Brain Pathol. 2017;27:205\u201312.","journal-title":"Brain Pathol"},{"key":"2018_CR15","doi-asserted-by":"crossref","unstructured":"Zhao LZ, Guo HL, Shi YW, et al. Role of pyroptosis in cardiovascular disease. Cell Prolif. 2018; e12563.","DOI":"10.1111\/cpr.12563"},{"issue":"3","key":"2018_CR16","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.coph.2004.12.005","volume":"5","author":"I Demedts","year":"2005","unstructured":"Demedts I, Brusselle G, Bracke K, Vermaelen K, Pauwels R. Matrix metalloproteinases in asthma and COPD. Curr Opin Pharmacol. 2005;5(3):257\u201363.","journal-title":"Curr Opin Pharmacol"},{"issue":"4","key":"2018_CR17","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.humpath.2005.11.023","volume":"37","author":"S Fligiel","year":"2006","unstructured":"Fligiel S, Standiford T, Fligiel H, Tashkin D, Strieter R, Warner R, Johnson K, Varani J. Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury. Hum Pathol. 2006;37(4):422\u201330.","journal-title":"Hum Pathol"},{"key":"2018_CR18","doi-asserted-by":"crossref","unstructured":"Kim EH, Kim ES, Shin D, Kim D, Choi S, Shin YJ, Kim KA, Noh D, Caglayan AB, Rajanikant GK et al. Carnosine protects against cerebral ischemic injury by inhibiting matrix-metalloproteinases. Int J Mol Sci. 2021;22(14).","DOI":"10.3390\/ijms22147495"},{"issue":"4","key":"2018_CR19","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1007\/s10753-020-01214-z","volume":"43","author":"Y Xu","year":"2020","unstructured":"Xu Y, Niu Y, Li H, Pan G. Downregulation of lncRNA TUG1 attenuates inflammation and apoptosis of renal tubular epithelial cell induced by ischemia-reperfusion by sponging miR-449b-5p via targeting HMGB1 and MMP2. Inflammation. 2020;43(4):1362\u201374.","journal-title":"Inflammation"},{"issue":"5","key":"2018_CR20","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1002\/hep.31179","volume":"72","author":"X Wang","year":"2020","unstructured":"Wang X, Walkey CJ, Maretti-Mira AC, Wang L, Johnson DL, DeLeve LD. Susceptibility of Rat Steatotic Liver to Ischemia-Reperfusion Is Treatable With Liver-Selective Matrix Metalloproteinase Inhibition. Hepatology (Baltimore, MD). 2020;72(5):1771\u201385.","journal-title":"Hepatology (Baltimore, MD)"},{"issue":"5","key":"2018_CR21","first-page":"1021","volume":"116","author":"A Roczkowsky","year":"2020","unstructured":"Roczkowsky A, Chan BYH, Lee TYT, Mahmud Z, Hartley B, Julien O, Armanious G, Young HS, Schulz R. Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischaemia-reperfusion injury. Cardiovasc Res. 2020;116(5):1021\u201331.","journal-title":"Cardiovasc Res"},{"issue":"5","key":"2018_CR22","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1093\/cvr\/cvz271","volume":"116","author":"JD Horowitz","year":"2020","unstructured":"Horowitz JD, Chong CR. Matrix metalloproteinase-2 activation: critical to myocardial contractile dysfunction following ischaemia-reperfusion. Cardiovasc Res. 2020;116(5):876\u20138.","journal-title":"Cardiovasc Res"},{"issue":"7","key":"2018_CR23","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1097\/00007890-200010150-00002","volume":"70","author":"PM Soccal","year":"2000","unstructured":"Soccal PM, Gasche Y, Pache JC, Schneuwly O, Slosman DO, Morel DR, Spiliopoulos A, Suter PM, Nicod LP. Matrix metalloproteinases correlate with alveolar-capillary permeability alteration in lung ischemia-reperfusion injury. Transplantation. 2000;70(7):998\u20131005.","journal-title":"Transplantation"},{"issue":"5","key":"2018_CR24","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1016\/j.transproceed.2009.02.076","volume":"41","author":"DY Yeh","year":"2009","unstructured":"Yeh DY, Lin HI, Feng NH, Chen CF, Wang D, Wang NT. Matrix metalloprotease expressions in both reperfusion lung injury and oleic acid lung injury models and the protective effects of ilomastat. Transpl Proc. 2009;41(5):1508\u201311.","journal-title":"Transpl Proc"},{"key":"2018_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114078","volume":"274","author":"J Wang","year":"2021","unstructured":"Wang J, Deng B, Liu J, Liu Q, Guo Y, Yang Z, Fang C, Lu L, Chen Z, Xian S, et al. Xinyang Tablet inhibits MLK3-mediated pyroptosis to attenuate inflammation and cardiac dysfunction in pressure overload. J Ethnopharmacol. 2021;274: 114078.","journal-title":"J Ethnopharmacol"},{"issue":"7","key":"2018_CR26","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s13205-021-02708-9","volume":"11","author":"D Huang","year":"2021","unstructured":"Huang D, Zhang LL, Zhou B, Luo ZZ, Zhang J, Tang B, Yu SC. Rapamycin inhibits LOC102553434-mediated pyroptosis to improve lung injury induced by limb ischemia-reperfusion. 3 Biotech. 2021;11(7):335.","journal-title":"3 Biotech"},{"issue":"2\u20133","key":"2018_CR27","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.ejphar.2008.11.037","volume":"602","author":"H Wu","year":"2009","unstructured":"Wu H, Dong G, Liu H, Xu B, Li D, Jing H. Erythropoietin attenuates ischemia-reperfusion induced lung injury by inhibiting tumor necrosis factor-alpha and matrix metalloproteinase-9 expression. Eur J Pharmacol. 2009;602(2\u20133):406\u201312.","journal-title":"Eur J Pharmacol"},{"key":"2018_CR28","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.brainres.2018.06.029","volume":"1699","author":"S Rashad","year":"2018","unstructured":"Rashad S, Niizuma K, Sato-Maeda M, Fujimura M, Mansour A, Endo H, Ikawa S, Tominaga T. Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis. Brain Res. 2018;1699:54\u201368.","journal-title":"Brain Res"},{"issue":"9","key":"2018_CR29","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/S1474-4422(05)70159-9","volume":"4","author":"R Nelson","year":"2005","unstructured":"Nelson R. Novel MMP inhibitor has potential for treatment of stroke. Lancet Neurol. 2005;4(9):530.","journal-title":"Lancet Neurol"},{"issue":"8","key":"2018_CR30","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1161\/CIRCRESAHA.113.301207","volume":"113","author":"P Ludewig","year":"2013","unstructured":"Ludewig P, Sedlacik J, Gelderblom M, Bernreuther C, Korkusuz Y, Wagener C, Gerloff C, Fiehler J, Magnus T, Horst AK. Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits MMP-9-mediated blood-brain-barrier breakdown in a mouse model for ischemic stroke. Circ Res. 2013;113(8):1013\u201322.","journal-title":"Circ Res"},{"issue":"1","key":"2018_CR31","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s13073-020-00780-z","volume":"12","author":"Y Ye","year":"2020","unstructured":"Ye Y, Kuang X, Xie Z, Liang L, Zhang Z, Zhang Y, Ma F, Gao Q, Chang R, Lee HH, Zhao S, Su J, Li H, Peng J, Chen H, Yin M, Peng C, Yang N, Wang J, Liu J, Liu H, Han L, Chen X. Small-molecule MMP2\/MMP9 inhibitor SB-3CT modulates tumor immune surveillance by regulating PD-L1. Genome Med. 2020;12(1):83. https:\/\/doi.org\/10.1186\/s13073-020-00780-z.","journal-title":"Genome Med"},{"issue":"4","key":"2018_CR32","doi-asserted-by":"publisher","first-page":"3031","DOI":"10.1016\/j.bbrc.2018.08.089","volume":"503","author":"K Xu","year":"2018","unstructured":"Xu K, Wu C, Tong S, et al. The selective Nlrp3 inflammasome inhibitor Mcc950 attenuates lung ischemia-reperfusion injury. Biochem Biophys Res Commun. 2018;503(4):3031\u20137.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"2018_CR33","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1186\/s12967-020-02467-w","volume":"18","author":"L Fei","year":"2020","unstructured":"Fei L, Jingyuan X, Fangte L, Huijun D, Liu Y, Ren J, Jinyuan L, Linghui P. Preconditioning with rHMGB1 ameliorates lung ischemia-reperfusion injury by inhibiting alveolar macrophage pyroptosis via the Keap1\/Nrf2\/HO-1 signaling pathway. J Transl Med. 2020;18(1):301.","journal-title":"J Transl Med"},{"issue":"12","key":"2018_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.734485","volume":"27","author":"P Zhou","year":"2021","unstructured":"Zhou P, Yang C, Zhang S, et al. The imbalance of MMP-2\/TIMP-2 and MMP-9\/TIMP-1 contributes to collagen deposition disorder in diabetic non-injured skin. Front Endocrinol (Lausanne). 2021;27(12): 734485.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"2018_CR35","doi-asserted-by":"publisher","first-page":"1902222","DOI":"10.1183\/13993003.02222-2019","volume":"55","author":"A Wong","year":"2020","unstructured":"Wong A, Zamel R, Yeung J, et al. Potential therapeutic targets for lung repair during human ex vivo lung perfusion. Eur Respir J. 2020;55(4):1902222.","journal-title":"Eur Respir J"},{"key":"2018_CR36","unstructured":"Egan TM, Doanes M, Jin JP, Randell S. Gene Expression Changes due to Rat Lung Ischemia-Reperfusion Injury. 2019 Apr https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE9634"},{"issue":"1","key":"2018_CR37","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/s11596-013-1077-z","volume":"33","author":"Y-l Shi","year":"2013","unstructured":"Shi Y-l, Xu T, Li L-p, Chen X-p. Over-expression of VEGF and MMP-9 in residual tumor cells of hepatocellular carcinoma after embolization with lipidol. J Huazhong Univ Sci Technol [Med Sci]. 2013;33(1):90\u20135.","journal-title":"J Huazhong Univ Sci Technol [Med Sci]"},{"issue":"3","key":"2018_CR38","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1160\/TH03-05-0272","volume":"91","author":"JP Kuyvenhoven","year":"2004","unstructured":"Kuyvenhoven JP, Molenaar IQ, Verspaget HW, et al. Plasma MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 during human orthotopic liver transplantation. The effect of aprotinin and the relation to ischemia\/reperfusion injury. Thromb Haemost. 2004;91(3):506\u201313.","journal-title":"Thromb Haemost"},{"issue":"3","key":"2018_CR39","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/s41419-020-2367-6","volume":"11","author":"SK Yadav","year":"2020","unstructured":"Yadav SK, Kambis TN, Kar S, Park SY, Mishra PK. MMP9 mediates acute hyperglycemia-induced human cardiac stem cell death by upregulating apoptosis and pyroptosis in vitro. Cell Death Dis. 2020;11(3):186.","journal-title":"Cell Death Dis"},{"issue":"1","key":"2018_CR40","first-page":"17","volume":"18","author":"HE Zhi-jie","year":"2009","unstructured":"Zhi-jie HE, Zi-tong H, Zi-jun ZOU, Xiao-tong C, Tong W. Changes of matrix metalloproteinase-9 and blood brain barrier in cardiopulmonary resuscitation rats and effects of MMP-9 inhibitor on them. Chin J Emerg Med. 2009;18(1):17\u201321.","journal-title":"Chin J Emerg Med"},{"issue":"6","key":"2018_CR41","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/S1053-2498(01)00250-9","volume":"20","author":"M Yano","year":"2001","unstructured":"Yano M, Omoto Y, Yamakawa Y, Nakashima Y, Kiriyama M, Saito Y, Fujii Y. Increased matrix metalloproteinase 9 activity and mRNA expression in lung ischemia-reperfusion injury. J Heart Lung Transplant. 2001;20(6):679\u201386.","journal-title":"J Heart Lung Transplant"},{"key":"2018_CR42","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.vph.2005.08.011","volume":"43","author":"N Marczin","year":"2005","unstructured":"Marczin N. The biology of exhaled nitric oxide (NO) in ischemia-reperfusion-induced lung injury: a tale of dynamism of NO production and consumption. Vascul Pharmacol. 2005;43:415\u201324.","journal-title":"Vascul Pharmacol"},{"issue":"5","key":"2018_CR43","doi-asserted-by":"publisher","first-page":"H1283","DOI":"10.1152\/ajpheart.00251.2010","volume":"299","author":"H Den","year":"2010","unstructured":"Den H, Gielis J, Lin J, et al. Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process. Am J Physiol Heart Circ Physiol. 2010;299(5):H1283\u201399.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"2018_CR44","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1046\/j.1600-6135.2003.00277.x","volume":"4","author":"PM Soccal","year":"2004","unstructured":"Soccal PM, Gasche Y, Miniati DN, et al. Matrix metalloproteinase inhibition decreases ischemia-reperfusion injury after lung transplantation. Am J Transplant. 2004;4(1):41\u201350.","journal-title":"Am J Transplant"},{"issue":"3","key":"2018_CR45","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1159\/000485401","volume":"44","author":"H Liu","year":"2017","unstructured":"Liu H, Jing X, Dong A, Bai B, Wang H. Overexpression of TIMP3 protects against cardiac ischemia\/reperfusion injury by inhibiting myocardial apoptosis through ROS\/Mapks pathway. Cell Physiol Biochem. 2017;44(3):1011\u201323.","journal-title":"Cell Physiol Biochem"},{"issue":"5","key":"2018_CR46","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1007\/s11596-020-2265-2","volume":"40","author":"L Wang","year":"2020","unstructured":"Wang L, Zhang C-g, Jia Y-l, Hu L. Tissue inhibitor of metalloprotease-1 (TIMP-1) regulates adipogenesis of adipose-derived stem cells (ASCs) via the Wnt signaling pathway in an MMP-independent manner. Curr Med Sci. 2020;40(5):989\u201396.","journal-title":"Curr Med Sci"},{"issue":"2","key":"2018_CR47","doi-asserted-by":"publisher","first-page":"H224","DOI":"10.1152\/ajpheart.00108.2017","volume":"313","author":"A Takawale","year":"2017","unstructured":"Takawale A, Zhang P, Azad A, Wang W, Wang X, Murray AG, Kassiri Z. Myocardial overexpression of TIMP3 after myocardial infarction exerts beneficial effects by promoting angiogenesis and suppressing early proteolysis. Am J Physiol Heart Circ Physiol. 2017;313(2):H224-h236.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"2018_CR48","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1097\/FJC.0000000000000694","volume":"74","author":"A Rauf","year":"2019","unstructured":"Rauf A, Shah M, Yellon DM, Davidson SM. Role of caspase 1 in ischemia\/reperfusion injury of the myocardium. J Cardiovasc Pharmacol. 2019;74(3):194\u2013200.","journal-title":"J Cardiovasc Pharmacol"},{"issue":"1","key":"2018_CR49","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/s41418-019-0351-4","volume":"27","author":"P Wan","year":"2020","unstructured":"Wan P, Su W, Zhang Y, Li Z, Deng C, Li J, Jiang N, Huang S, Long E, Zhuo Y. LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia\/reperfusion injury. Cell Death Differ. 2020;27(1):176\u201391.","journal-title":"Cell Death Differ"},{"issue":"1","key":"2018_CR50","doi-asserted-by":"publisher","first-page":"865","DOI":"10.18632\/aging.202191","volume":"13","author":"Z Liu","year":"2020","unstructured":"Liu Z, Meng Y, Miao Y, Yu L, Yu Q. Propofol reduces renal ischemia\/reperfusion-induced acute lung injury by stimulating sirtuin 1 and inhibiting pyroptosis. Aging. 2020;13(1):865\u201376.","journal-title":"Aging"},{"issue":"1","key":"2018_CR51","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.semcdb.2007.07.003","volume":"19","author":"AM Manicone","year":"2008","unstructured":"Manicone AM, McGuire JK. Matrix metalloproteinases as modulators of inflammation. Semin Cell Dev Biol. 2008;19(1):34\u201341.","journal-title":"Semin Cell Dev Biol"},{"key":"2018_CR52","doi-asserted-by":"publisher","first-page":"7479107","DOI":"10.1155\/2019\/7479107","volume":"2019","author":"S Esnault","year":"2019","unstructured":"Esnault S, Kelly E, Johnson S, DeLain L, Haedt M, Noll A, Sandbo N, Jarjour N. \u03b2Matrix metalloproteinase-9-dependent release of IL-1 by human eosinophils. Mediators Inflamm. 2019;2019:7479107.","journal-title":"Mediators Inflamm"},{"key":"2018_CR53","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1750-1326-7-21","volume":"7","author":"J Cui","year":"2012","unstructured":"Cui J, Chen S, Zhang C, Meng F, Wu W, Hu R, Hadass O, Lehmidi T, Blair G, Lee M, et al. Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia. Mol Neurodegener. 2012;7:21.","journal-title":"Mol Neurodegener"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-022-02018-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12890-022-02018-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12890-022-02018-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T15:03:13Z","timestamp":1655305393000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/s12890-022-02018-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,15]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["2018"],"URL":"https:\/\/doi.org\/10.1186\/s12890-022-02018-7","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,15]]},"assertion":[{"value":"24 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study is reported in accordance with ARRIVE guidelines. <i>Animal<\/i>\u00a0experiments were ethically approved by the experimental\u00a0<i>animal<\/i>\u00a0welfare and ethics committee of Wuhan Union Hospital. (Wuhan, China;\u00a0<i>approval<\/i>\u00a0<i>no. 81900432<\/i>.)","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no proprietary or commercial conflicts of interest to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"230"}}