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Since ARDS is associated with immune dysregulation and coagulation abnormalities, it is necessary to identify an appropriate predictor that can accurately predict ARDS mortality based on its pathophysiology. Therefore, this study aimed to evaluate the clinical value of neutrophils to lymphocytes and platelets ratio (N\/LPR) in predicting 28-day mortality in ARDS patients.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>From July 2018 to October 2021, the medical records of ARDS patients were retrospective reviewed. Neutrophil count, lymphocyte count, and platelet count were collected, and the neutrophil-to-lymphocyte ratio (NLR) and N\/LPR were calculated. Multivariate logistic regression analyses were performed to identify independent predictors of 28-day mortality in ARDS. Receiver operating characteristic (ROC) curve with the area under curve (AUC) was used to evaluate optimal cut-off values for 28-day mortality in ARDS. Kaplan\u2013Meier analysis was used to estimate the 28-day survival probabilities stratified by optimal cut-off values of N\/LPR and NLR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 136 ARDS patients were included in this study and were further divided into survivors (<jats:italic>n<\/jats:italic>\u2009=\u200969) and non-survivors (<jats:italic>n<\/jats:italic>\u2009=\u200967) groups according to their survival status on day 28. There were no significant differences between the two groups in age, sex, history of smoking and drinking, comorbidities, and reasons of admission (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Non-survivors had significantly higher neutrophil counts, NLR and N\/LPR and had significantly lower platelet counts than survivors (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Multivariate regression analysis revealed that N\/LPR, NLR and platelet counts were independent predictors for 28-day mortality in ARDS (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The ROC analyses showed that N\/LPR with optimal cut-off value of 10.57 (sensitivity: 74.6%; specificity: 72.5%) is a more reliable predictor for 28-day mortality in ARDS than NLR and platelet count (AUC: 0.785 vs. 0.679 vs. 0.326). Further subgroup analysis confirmed that ARDS patients with N\/LPR\u2009&lt;\u200910.57 had significantly lower 28-day mortality than patients with N\/LPR\u2009\u2265\u200910.57 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Kaplan\u2013Meier analysis also confirmed that ARDS patients with N\/LPR\u2009&lt;\u200910.57 had significantly longer survival.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>N\/LPR is an independent risk factor associated with 28-day mortality in ARDS patients and shows better performance in predicting mortality rate than NLR.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-022-02112-w","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T07:02:58Z","timestamp":1660546978000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prognostic value of neutrophils to lymphocytes and platelets ratio for 28-day mortality in patients with acute respiratory distress syndrome: a retrospective study"],"prefix":"10.1186","volume":"22","author":[{"given":"Shiyu","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"issue":"7","key":"2112_CR1","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1164\/rccm.201612-2495CI","volume":"196","author":"WR Henderson","year":"2017","unstructured":"Henderson WR, Chen L, Amato MBP, et al. 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The requirement of written informed consent was waived by the IRB of Chongqing Medical University due to the retrospective nature of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"314"}}