{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T06:11:12Z","timestamp":1668665472265},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Aspergillus tracheobronchitis (ATB) is confined as a condition of chronic superficial infection of tracheobronchial tree. Its diagnosis is difficult due to atypical manifestations and low detective rate of Aspergillus thus far.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation:<\/jats:title>\n                <jats:p>Herein, we presented a 45-year-old male patient with a sole chronic productive cough for five years referred to our cough specialist clinic. Chest high-resolution computed tomography showed multiple lung cysts predominantly located in the subpleural lesions and near the mediastinum. Neither bacteria nor fungi were identified by sputum culture. However, metagenomic next-generation sequencing in sputum detected Aspergillus fumigatus DNA. The genetic testing of whole blood suggested the germline mutation of the tumor suppressor gene folliculin, supporting a diagnosis of Birt-Hogg-Dub\u00e9 (BHD) syndrome. His productive cough symptom significantly improved after receiving itraconazole treatment for 2 months. After discontinuation of antifungal treatment, there was no relapse for four months follow-up. A diagnosis of ATB with BHD syndrome was eventually established in this patient.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>ATB should be considered in any patient with prolonged unexplained productive cough. Next-generation sequencing technologies may be useful to identify ATB which is uncommon and easily ignored in clinical practice.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12890-022-02136-2","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T22:02:41Z","timestamp":1668636161000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aspergillus tracheobronchitis with Birt-Hogg-Dub\u00e8 syndrome as a rare cause of chronic cough"],"prefix":"10.1186","volume":"22","author":[{"given":"Lianrong","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kefang","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"issue":"4","key":"2136_CR1","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1080\/02770900902846331","volume":"46","author":"H Ogawa","year":"2009","unstructured":"Ogawa H, Fujimura M, Takeuchi Y, Makimura K. Efficacy of itraconazole in the treatment of patients with chronic cough whose sputa yield basidiomycetous fungi-fungus-associated chronic cough (FACC). J Asthma. 2009;46(4):407\u201312.","journal-title":"J Asthma"},{"key":"2136_CR2","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1100\/2011\/865239","volume":"11","author":"R Krenke","year":"2011","unstructured":"Krenke R, Grabczak EM. Tracheobronchial manifestations of Aspergillus infections. Sci World J. 2011;11:2310\u201329.","journal-title":"Sci World J"},{"issue":"6","key":"2136_CR3","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1111\/j.1469-0691.2009.02923.x","volume":"16","author":"N Wu","year":"2010","unstructured":"Wu N, Huang Y, Li Q, Bai C, Huang HD, Yao XP. Isolated invasive Aspergillus tracheobronchitis: a clinical study of 19 cases. 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A copy of the written consent is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competinxg interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"420"}}